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description Publicationkeyboard_double_arrow_right Conference object , Article 2023Publisher:IEEE Ilias, Maoudj; Charles, Garraud; Celine, Panheleux; Vanessa, Saliou; Romuald, Seizeur; Guillaume, Dardenne;pmid: 38083163
Awake Surgery (AS) is considered the best treatment for brain tumors located in or near eloquent areas. During this intervention, Direct Electrical Stimulations (DES) are delivered by the surgeon on the patient's brain in order to obtain an accurate brain mapping of the patient. The patient is asked to perform various tasks (e.g. counting, object naming, emotion recognition) through neuropsychological tests during these stimulations. These DES may cause a reversible lesion inducing deficits on the patient which can be observed during these tasks by the medical staff. The resection is then performed or not according to the patient's response. The intraoperative deficits can take several forms and can be difficult to analyze and identify. The development of new solutions allowing the automatic detection of these deficits could be therefore essential. However, still today, no structured and organized AS dedicated database is available that could be used to train and test these algorithms. We propose a modular system allowing the synchronized multimodal acquisition of various information including physiological measurements, DES signals and parameters, and task-related data to create such database.Clinical relevance- Acquiring synchronized multimodal data during AS will allow the creation of a dedicated database that could then be used to reveal new correlations between DES and the patient's response, and to develop and test new algorithms for the automatic detection of deficits.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1109/embc40...Conference object . 2023 . Peer-reviewedLicense: STM Policy #29Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1109/embc40...Conference object . 2023 . Peer-reviewedLicense: STM Policy #29Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2022 Germany EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Bitsch, Lise; Bjaalie, Jan; Brovelli, Andrea; Caspers, Svenja; Changeux, Jean-Pierre; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Duqué, Julie; Düzel, Emrah; Eickhoff, Simon B.; Engel, Andreas K.; Evers, Kathinka; Fousek, Jan; Furber, Stephen; Goebel, Rainer; Güntürkün, Onur; De Kerchove d'Exaerde, Alban; Hellgren Kotaleski, Jeanette; Krsnik, Zeljka; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Lippert, Thomas; Maquet, Pierre; Marinazzo, Daniele; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Morin, Fabrice; Nagels, Guy; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petrovici, Mihai A.; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Van Albada, Sacha Jennifer; Vanduffel, Wim; De Vos, Winnok;handle: 2128/31607
Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after.
Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic ResourcesJuelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 2Kvisibility views 1,889 download downloads 1,530 Powered bymore_vert Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic ResourcesJuelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type 2022 Germany EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Eickhoff, Simon B.; Engel, Andreas; Fousek, Jan; Furber, Stephen; Goebel, Rainer; Günterkün, Onur; Hellgren Kotaleski, Jeanette; Bitsch, Lise; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Lippert, Thomas; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Bjaalie, Jan; Morin, Fabrice; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Petkoski, Spase; Petrovici, Mihai A.; Ritter, Petra; Rotter, Stefan; Rowald, Andreas; Brovelli, Andrea; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Vanduffel, Wim; Caspers, Svenja; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; DeFelipe, Javier;handle: 2128/30880
Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after.
Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3Kvisibility views 3,494 download downloads 2,779 Powered bymore_vert Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Research , Other literature type 2023 EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Banerjee, Swati; Bitsch, Lise; Bjaalie, Jan G.; Brauner Philipp; Brovelli, Andrea; Calarco Navona; Carrere, Marcel; Caspers, Svenja; Charvet Christine; Cichon, Sven; Cools, Roshan; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Düzel, Emrah; Eickhoff, Simon B.; Gaute Einevoll; Eke Damian; Engel, Andreas K.; Evans Alan Charles; Evers, Kathinka; Forkel, Stephanie; Fousek, Jan; Friederici, Angela D.; Friston, Karl; Furber, Stephen; Geris Liesbet; Goebel, Rainer; Güntürkün, Onur; Abd Hamid, Aini Ismafairus; Herold Christina; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Kashyap Sriranga; Burkhard, Kasper; De Kerchove d'Exaerde, Alban; Kooijmans, Roxana; Koren István; Hellgren Kotaleski, Jeanette; Kiar Gregory; Klijn, Wouter; Klüver, Lars; Knoll, Alois C.; Krsnik, Zeljka; Kämpfer, Julia; Larkum, Matthew E; Linne, Marja-Leena; Lippert, Thomas; Abdullah, Jafri Malin; Di Maio, Paola; Magielse Neville; Maquet, Pierre; Mascaro, Anna Letizia Allegra; Marinazzo, Daniele; Jorge Mejias; Meyer-Lindenberg, Andreas; Migliore, Michele; Michael Judith; Morel, Yannick; Morin, Fabrice; Muckli, Lars; Nagels, Guy; Oden, Lena; Palomero-Gallagher, Nicola; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petkov, Nicolai; Petro, Lucy S.; Petrovici, Mihai A.; Pezzulo Giovanni; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rockland, Kathleen; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Senn, Walter; Sousa Alexandra A. de; Ströckens Felix; Thirion, Betrand; Uludağ Kâmil; Vanni, Simo; Van Albada, Sacha Jennifer; Vanduffel, Wim; Vezoli, Julien; Vincenz-Donnelly, Lisa; Walter, Florian; Zaborszky, Laszlo;Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe's Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a 'one size fits all' approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. As the final version 5 has now been published, comments on this manuscript are now closed. We thank everyone who made a valuable contribution to this paper. This manuscript has been developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP), and the entire research community was invited to contribute to shaping the vision by submitting comments. All submitted comments were considered and discussed. The final decision on whether edits or additions was made to each version of the manuscript based on an individual comment was made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP). Supporters of the paper: Pietro Avanzini, Marc Beyer, Maria Del Vecchio, Jitka Annen, Maurizio Mattia, Steven Laureys, Rosanne Edelenbosch, Rafael Yuste, Jean-Pierre Changeux, Linda Richards, Hye Weon Jessica Kim, Chrysoula Samara, Luis Miguel González de la Garza, Nikoleta Petalidou, Vasudha Kulkarni, Cesar David Rincon, Isabella O'Shea, Munira Tamim Electricwala, Bernd Carsten Stahl, Bahar Hazal Yalcinkaya, Meysam Hashemi, Carola Sales Carbonell, Marcel Carrère, Anthony Randal McIntosh, Hiba Sheheitli, Abolfazl Ziaeemehr, Martin Breyton, Giovanna Ramos Queda, Anirudh NIhalani Vattikonda, Gyorgy Buzsaki, George Ogoh, William Knight, Torbjørn V Ness, Michiel van der Vlag, Marcello Massimini, Thomas Nowontny, Alex Upton, Yaseen Jakhura, Ahmet Nihat Simsek, Michael Hopkins, Addolorata Marasco, Shamim Patel, Jakub Fil, Diego Molinari, Susana Bueno, Lia Domide, Cosimo Lupo, Mu-ming Poo, George Paxinos, Huifang Wang.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Bitsch, Lise; Bjaalie, Jan G.; Brovelli, Andrea; Caspers, Svenja; Cichon, Sven; Cools, Roshan; Changeux, Jean-Pierre; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Duqué, Julie; Düzel, Emrah; Eickhoff, Simon B.; Engel, Andreas K.; Evers, Kathinka; Fousek, Jan; Friederici, Angela D.; Friston, Karl; Furber, Stephen; Goebel, Rainer; Güntürkün, Onur; De Kerchove d'Exaerde, Alban; Hellgren Kotaleski, Jeanette; Krsnik, Zeljka; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Klüver, Lars; Knoll, Alois C.; Larkum, Matthew E; Linne, Marja-Leena; Lippert, Thomas; Maquet, Pierre; Mascaro, Anna Letizia Allegra; Martinez, Sara Christina; Marinazzo, Daniele; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Morin, Fabrice; Muckli, Lars; Nagels, Guy; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petkov, Nicolai; Petro , Lucy S.; Petrovici, Mihai A.; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rockland, Kathleen; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Vanni, Simo; Van Albada, Sacha Jennifer; Vanduffel, Wim; De Vos, Winnok; Vezoli, Julien; Vincenz-Donnelly, Lisa; Walter, Florian; Zaborszky, Laszlo;Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. You can submit your comments here and be considered for co-authorship Or become a supporter by clicking here More information below Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after. Supporters of the paper: Pietro Avanzini, Marc Beyer, Maria Del Vecchio, Jitka Annen, Maurizio Mattia, Steven Laureys, Rosanne Edelenbosch, Rafael Yuste, Jean-Pierre Changeux, Linda Richards.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019Publisher:Elsevier BV Authors: Alain, Dagher; Stéphane, Lehéricy; James B, Rowe; Hartwig R, Siebner;Alain, Dagher; Stéphane, Lehéricy; James B, Rowe; Hartwig R, Siebner;pmid: 30798013
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 EnglishPublisher:Cureus Esplin, Nathan; Stelzer, John W; All, Sean; Kumar, Sundeep; Ghaffar, Ejaz; Ali, Sayed;pmc: PMC5714405
pmid: 29218260
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography. A 70-year-old male presented, obtunded, with a Glasgow Coma Score of eight. The patient seized on arrival. A computed tomography scan was read as a subdural hemorrhage, and magnetic resonance imaging showed a heterogeneous area at the anterior tip of the left frontal lobe interpreted as a frontoparietal abscess, along with pansinusitis. Craniotomy revealed a loculated abscess. Culture grew only Streptococcus anginosus. The patient did well postoperatively, was extubated by day five with rapidly improving neurological function, and was discharged to inpatient rehab by hospital-day eight for the continuation of intravenous antibiotics. This case represents a frontal lobe abscess caused by the contiguous spread of Streptococcus anginosus from a frontal sinus infection. This is a relatively rare presentation of SAG infection in an immunocompetent patient. The case outlines the importance of imaging modality choice in the various stages of brain abscess formation, and the necessity of maintaining an index of suspicion for brain abscess in patients with few traditional risk factors and little to no history on presentation.
Cureus arrow_drop_down CureusArticle . 2017Full-Text: http://europepmc.org/articles/PMC5714405Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 6 citations 6 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Cureus arrow_drop_down CureusArticle . 2017Full-Text: http://europepmc.org/articles/PMC5714405Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Marco, Bruschi; Jacques, Grill; Léa, Guerrini-Rousseau;Marco, Bruschi; Jacques, Grill; Léa, Guerrini-Rousseau;pmid: 34431811
Purpose of reviewBrain tumors are the most frequent solid cancer in the pediatric population. Owing to the rarity of environmental clues about their origin, it is tempting to consider these neoplasms as developmental processes gone awry. Our review will explore the heuristic power of this hypothesis and the influence of these findings on the clinical management.Recent findingA more accurate description of cancer predisposition syndrome has shown their frequent association with developmental abnormalities. Several genes involved in pediatric brain tumor oncogenesis are involved in developmental processes. Modeling of several pediatric brain tumor in cerebral organoids, mimicking embryonal stage of brain development, indicates that early events during brain development create the conditions necessary for their oncogenesis.SummaryThe onset of multiple brain tumor types early in life suggests a functional relationship between brain development and oncogenesis. A growing body of evidence seems to support the hypothesis that some of the main developmental steps in the brain can be highjacked by the tumors during their initiation. Collaborations between neuroscientists and oncologists should provide room for improvement in the knowledge for these neoplasms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, NetherlandsPublisher:Elsevier BV Roth, P.; Pace, A.; Rhun, E. le; Weller, M.; Ay, C.; Moyal, E.C.J.; Coomans, M.; Giusti, R.; Jordan, K.; Nishikawa, R.; Winkler, F.; Hong, J.T.; Ruda, R.; Villa, S.; Taphoorn, M.J.B.; Wick, W.; Preusser, M.; EANO Executive Board; ESMO Guidelines Comm;NARCIS arrow_drop_down Archivio Istituzionale (AperTO); Annals of Oncology; NARCISArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryArticle . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down Archivio Istituzionale (AperTO); Annals of Oncology; NARCISArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryArticle . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Italy, FrancePublisher:Society for Neuroscience Funded by:EC | VirtualBrainCloud, EC | HBP SGA3EC| VirtualBrainCloud ,EC| HBP SGA3Authors: Sorrentino, Pierpaolo; Petkoski, Spase; Sparaco, Maddalena; Troisi Lopez, Emahnuel; +7 AuthorsSorrentino, Pierpaolo; Petkoski, Spase; Sparaco, Maddalena; Troisi Lopez, Emahnuel; Signoriello, Elisabetta; Baselice, Fabio; Bonavita, Simona; Pirozzi, Maria Agnese; Quarantelli, Mario; Sorrentino, Giuseppe; Jirsa, Viktor;Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain in humans (of either sex) using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracts were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-tract level. International audience
Journal of Neuroscie... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03851744/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Journal of Neuroscie... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03851744/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Conference object , Article 2023Publisher:IEEE Ilias, Maoudj; Charles, Garraud; Celine, Panheleux; Vanessa, Saliou; Romuald, Seizeur; Guillaume, Dardenne;pmid: 38083163
Awake Surgery (AS) is considered the best treatment for brain tumors located in or near eloquent areas. During this intervention, Direct Electrical Stimulations (DES) are delivered by the surgeon on the patient's brain in order to obtain an accurate brain mapping of the patient. The patient is asked to perform various tasks (e.g. counting, object naming, emotion recognition) through neuropsychological tests during these stimulations. These DES may cause a reversible lesion inducing deficits on the patient which can be observed during these tasks by the medical staff. The resection is then performed or not according to the patient's response. The intraoperative deficits can take several forms and can be difficult to analyze and identify. The development of new solutions allowing the automatic detection of these deficits could be therefore essential. However, still today, no structured and organized AS dedicated database is available that could be used to train and test these algorithms. We propose a modular system allowing the synchronized multimodal acquisition of various information including physiological measurements, DES signals and parameters, and task-related data to create such database.Clinical relevance- Acquiring synchronized multimodal data during AS will allow the creation of a dedicated database that could then be used to reveal new correlations between DES and the patient's response, and to develop and test new algorithms for the automatic detection of deficits.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1109/embc40...Conference object . 2023 . Peer-reviewedLicense: STM Policy #29Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1109/embc40...Conference object . 2023 . Peer-reviewedLicense: STM Policy #29Data sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2022 Germany EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Bitsch, Lise; Bjaalie, Jan; Brovelli, Andrea; Caspers, Svenja; Changeux, Jean-Pierre; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Duqué, Julie; Düzel, Emrah; Eickhoff, Simon B.; Engel, Andreas K.; Evers, Kathinka; Fousek, Jan; Furber, Stephen; Goebel, Rainer; Güntürkün, Onur; De Kerchove d'Exaerde, Alban; Hellgren Kotaleski, Jeanette; Krsnik, Zeljka; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Lippert, Thomas; Maquet, Pierre; Marinazzo, Daniele; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Morin, Fabrice; Nagels, Guy; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petrovici, Mihai A.; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Van Albada, Sacha Jennifer; Vanduffel, Wim; De Vos, Winnok;handle: 2128/31607
Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after.
Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic ResourcesJuelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 2Kvisibility views 1,889 download downloads 1,530 Powered bymore_vert Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic ResourcesJuelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type 2022 Germany EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Eickhoff, Simon B.; Engel, Andreas; Fousek, Jan; Furber, Stephen; Goebel, Rainer; Günterkün, Onur; Hellgren Kotaleski, Jeanette; Bitsch, Lise; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Lippert, Thomas; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Bjaalie, Jan; Morin, Fabrice; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Petkoski, Spase; Petrovici, Mihai A.; Ritter, Petra; Rotter, Stefan; Rowald, Andreas; Brovelli, Andrea; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Vanduffel, Wim; Caspers, Svenja; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; DeFelipe, Javier;handle: 2128/30880
Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after.
Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3Kvisibility views 3,494 download downloads 2,779 Powered bymore_vert Juelich Shared Elect... arrow_drop_down Juelich Shared Electronic ResourcesPreprint . 2022Data sources: Juelich Shared Electronic Resourcesadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Research , Other literature type 2023 EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Banerjee, Swati; Bitsch, Lise; Bjaalie, Jan G.; Brauner Philipp; Brovelli, Andrea; Calarco Navona; Carrere, Marcel; Caspers, Svenja; Charvet Christine; Cichon, Sven; Cools, Roshan; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Düzel, Emrah; Eickhoff, Simon B.; Gaute Einevoll; Eke Damian; Engel, Andreas K.; Evans Alan Charles; Evers, Kathinka; Forkel, Stephanie; Fousek, Jan; Friederici, Angela D.; Friston, Karl; Furber, Stephen; Geris Liesbet; Goebel, Rainer; Güntürkün, Onur; Abd Hamid, Aini Ismafairus; Herold Christina; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Kashyap Sriranga; Burkhard, Kasper; De Kerchove d'Exaerde, Alban; Kooijmans, Roxana; Koren István; Hellgren Kotaleski, Jeanette; Kiar Gregory; Klijn, Wouter; Klüver, Lars; Knoll, Alois C.; Krsnik, Zeljka; Kämpfer, Julia; Larkum, Matthew E; Linne, Marja-Leena; Lippert, Thomas; Abdullah, Jafri Malin; Di Maio, Paola; Magielse Neville; Maquet, Pierre; Mascaro, Anna Letizia Allegra; Marinazzo, Daniele; Jorge Mejias; Meyer-Lindenberg, Andreas; Migliore, Michele; Michael Judith; Morel, Yannick; Morin, Fabrice; Muckli, Lars; Nagels, Guy; Oden, Lena; Palomero-Gallagher, Nicola; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petkov, Nicolai; Petro, Lucy S.; Petrovici, Mihai A.; Pezzulo Giovanni; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rockland, Kathleen; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Senn, Walter; Sousa Alexandra A. de; Ströckens Felix; Thirion, Betrand; Uludağ Kâmil; Vanni, Simo; Van Albada, Sacha Jennifer; Vanduffel, Wim; Vezoli, Julien; Vincenz-Donnelly, Lisa; Walter, Florian; Zaborszky, Laszlo;Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe's Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a 'one size fits all' approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. As the final version 5 has now been published, comments on this manuscript are now closed. We thank everyone who made a valuable contribution to this paper. This manuscript has been developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP), and the entire research community was invited to contribute to shaping the vision by submitting comments. All submitted comments were considered and discussed. The final decision on whether edits or additions was made to each version of the manuscript based on an individual comment was made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP). Supporters of the paper: Pietro Avanzini, Marc Beyer, Maria Del Vecchio, Jitka Annen, Maurizio Mattia, Steven Laureys, Rosanne Edelenbosch, Rafael Yuste, Jean-Pierre Changeux, Linda Richards, Hye Weon Jessica Kim, Chrysoula Samara, Luis Miguel González de la Garza, Nikoleta Petalidou, Vasudha Kulkarni, Cesar David Rincon, Isabella O'Shea, Munira Tamim Electricwala, Bernd Carsten Stahl, Bahar Hazal Yalcinkaya, Meysam Hashemi, Carola Sales Carbonell, Marcel Carrère, Anthony Randal McIntosh, Hiba Sheheitli, Abolfazl Ziaeemehr, Martin Breyton, Giovanna Ramos Queda, Anirudh NIhalani Vattikonda, Gyorgy Buzsaki, George Ogoh, William Knight, Torbjørn V Ness, Michiel van der Vlag, Marcello Massimini, Thomas Nowontny, Alex Upton, Yaseen Jakhura, Ahmet Nihat Simsek, Michael Hopkins, Addolorata Marasco, Shamim Patel, Jakub Fil, Diego Molinari, Susana Bueno, Lia Domide, Cosimo Lupo, Mu-ming Poo, George Paxinos, Huifang Wang.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.10035197&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type 2022 EnglishPublisher:Zenodo Funded by:EC | HBP SGA3EC| HBP SGA3Amunts, Katrin; Axer, Markus; Bitsch, Lise; Bjaalie, Jan G.; Brovelli, Andrea; Caspers, Svenja; Cichon, Sven; Cools, Roshan; Changeux, Jean-Pierre; Costantini, Irene; D'Angelo, Egidio; De Bonis, Giulia; Deco, Gustavo; DeFelipe, Javier; Destexhe, Alain; Dickscheid, Timo; Diesmann, Markus; Duqué, Julie; Düzel, Emrah; Eickhoff, Simon B.; Engel, Andreas K.; Evers, Kathinka; Fousek, Jan; Friederici, Angela D.; Friston, Karl; Furber, Stephen; Goebel, Rainer; Güntürkün, Onur; De Kerchove d'Exaerde, Alban; Hellgren Kotaleski, Jeanette; Krsnik, Zeljka; Hilgetag, Claus C.; Hölter, Sabine M.; Ioannidis, Yannis; Jirsa, Viktor; Klijn, Wouter; Kämpfer, Julia; Klüver, Lars; Knoll, Alois C.; Larkum, Matthew E; Linne, Marja-Leena; Lippert, Thomas; Maquet, Pierre; Mascaro, Anna Letizia Allegra; Martinez, Sara Christina; Marinazzo, Daniele; Meyer-Lindenberg, Andreas; Migliore, Michele; Morel, Yannick; Morin, Fabrice; Muckli, Lars; Nagels, Guy; Oden, Lena; Panagiotaropoulos, Fanis; Paolucci, Pier Stanislao; Pennartz, Cyriel; Peeters, Liesbet M.; Petkoski, Spase; Petkov, Nicolai; Petro , Lucy S.; Petrovici, Mihai A.; Roelfsema, Pieter; Ris, Laurence; Ritter, Petra; Rockland, Kathleen; Rotter, Stefan; Rowald, Andreas; Ruland, Sabine; Ryvlin, Philippe; Salles, Arleen; Sanchez-Vives, Maria V.; Schemmel, Johannes; Thirion, Betrand; Vanni, Simo; Van Albada, Sacha Jennifer; Vanduffel, Wim; De Vos, Winnok; Vezoli, Julien; Vincenz-Donnelly, Lisa; Walter, Florian; Zaborszky, Laszlo;Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals To provide a scientific framework for current and future development of EBRAINS To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research To identify and address key ethical and societal issues While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience. You can submit your comments here and be considered for co-authorship Or become a supporter by clicking here More information below Comments on this manuscript are welcome This manuscript is a living document that is being further developed in a participatory process. The work has been initiated by the Science and Infrastructure Board of the Human Brain Project (HBP). Now, the entire research community is invited to contribute to shaping the vision by submitting comments. Comments can be submitted via an online commentary form here. All submitted comments will be considered and discussed. The final decision on whether edits or additions will be made to the next version of the manuscript based on an individual comment will be made by the Science and Infrastructure Board (SIB) of the Human Brain Project (HBP) at regular intervals. New versions of the manuscript will be published every few months on Zenodo. Comments may be submitted until the beginning of 2023. During the Human Brain Project Summit 2023, the manuscript will be adopted by HBP and non-HBP participants, and a final version will be published shortly after. Supporters of the paper: Pietro Avanzini, Marc Beyer, Maria Del Vecchio, Jitka Annen, Maurizio Mattia, Steven Laureys, Rosanne Edelenbosch, Rafael Yuste, Jean-Pierre Changeux, Linda Richards.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7319334&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5281/zenodo.7319334&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019Publisher:Elsevier BV Authors: Alain, Dagher; Stéphane, Lehéricy; James B, Rowe; Hartwig R, Siebner;Alain, Dagher; Stéphane, Lehéricy; James B, Rowe; Hartwig R, Siebner;pmid: 30798013
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuroimage.2019.02.040&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuroimage.2019.02.040&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 EnglishPublisher:Cureus Esplin, Nathan; Stelzer, John W; All, Sean; Kumar, Sundeep; Ghaffar, Ejaz; Ali, Sayed;pmc: PMC5714405
pmid: 29218260
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography. A 70-year-old male presented, obtunded, with a Glasgow Coma Score of eight. The patient seized on arrival. A computed tomography scan was read as a subdural hemorrhage, and magnetic resonance imaging showed a heterogeneous area at the anterior tip of the left frontal lobe interpreted as a frontoparietal abscess, along with pansinusitis. Craniotomy revealed a loculated abscess. Culture grew only Streptococcus anginosus. The patient did well postoperatively, was extubated by day five with rapidly improving neurological function, and was discharged to inpatient rehab by hospital-day eight for the continuation of intravenous antibiotics. This case represents a frontal lobe abscess caused by the contiguous spread of Streptococcus anginosus from a frontal sinus infection. This is a relatively rare presentation of SAG infection in an immunocompetent patient. The case outlines the importance of imaging modality choice in the various stages of brain abscess formation, and the necessity of maintaining an index of suspicion for brain abscess in patients with few traditional risk factors and little to no history on presentation.
Cureus arrow_drop_down CureusArticle . 2017Full-Text: http://europepmc.org/articles/PMC5714405Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC5714405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 6 citations 6 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Cureus arrow_drop_down CureusArticle . 2017Full-Text: http://europepmc.org/articles/PMC5714405Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=PMC5714405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Marco, Bruschi; Jacques, Grill; Léa, Guerrini-Rousseau;Marco, Bruschi; Jacques, Grill; Léa, Guerrini-Rousseau;pmid: 34431811
Purpose of reviewBrain tumors are the most frequent solid cancer in the pediatric population. Owing to the rarity of environmental clues about their origin, it is tempting to consider these neoplasms as developmental processes gone awry. Our review will explore the heuristic power of this hypothesis and the influence of these findings on the clinical management.Recent findingA more accurate description of cancer predisposition syndrome has shown their frequent association with developmental abnormalities. Several genes involved in pediatric brain tumor oncogenesis are involved in developmental processes. Modeling of several pediatric brain tumor in cerebral organoids, mimicking embryonal stage of brain development, indicates that early events during brain development create the conditions necessary for their oncogenesis.SummaryThe onset of multiple brain tumor types early in life suggests a functional relationship between brain development and oncogenesis. A growing body of evidence seems to support the hypothesis that some of the main developmental steps in the brain can be highjacked by the tumors during their initiation. Collaborations between neuroscientists and oncologists should provide room for improvement in the knowledge for these neoplasms.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/cco.0000000000000782&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/cco.0000000000000782&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, NetherlandsPublisher:Elsevier BV Roth, P.; Pace, A.; Rhun, E. le; Weller, M.; Ay, C.; Moyal, E.C.J.; Coomans, M.; Giusti, R.; Jordan, K.; Nishikawa, R.; Winkler, F.; Hong, J.T.; Ruda, R.; Villa, S.; Taphoorn, M.J.B.; Wick, W.; Preusser, M.; EANO Executive Board; ESMO Guidelines Comm;NARCIS arrow_drop_down Archivio Istituzionale (AperTO); Annals of Oncology; NARCISArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryArticle . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.annonc.2020.11.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert NARCIS arrow_drop_down Archivio Istituzionale (AperTO); Annals of Oncology; NARCISArticle . 2021 . Peer-reviewedLicense: Elsevier Non-CommercialLUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryArticle . 2021License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.annonc.2020.11.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Italy, FrancePublisher:Society for Neuroscience Funded by:EC | VirtualBrainCloud, EC | HBP SGA3EC| VirtualBrainCloud ,EC| HBP SGA3Authors: Sorrentino, Pierpaolo; Petkoski, Spase; Sparaco, Maddalena; Troisi Lopez, Emahnuel; +7 AuthorsSorrentino, Pierpaolo; Petkoski, Spase; Sparaco, Maddalena; Troisi Lopez, Emahnuel; Signoriello, Elisabetta; Baselice, Fabio; Bonavita, Simona; Pirozzi, Maria Agnese; Quarantelli, Mario; Sorrentino, Giuseppe; Jirsa, Viktor;Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain in humans (of either sex) using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracts were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-tract level. International audience
Journal of Neuroscie... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03851744/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1523/jneurosci.0938-22.2022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Journal of Neuroscie... arrow_drop_down HAL Descartes; HAL AMU; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03851744/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1523/jneurosci.0938-22.2022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu