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description Publicationkeyboard_double_arrow_right Article 2014Publisher:Frontiers Media SA Funded by:NWO | Microbial support of plan...NWO| Microbial support of plant growth under abiotic stress (project 3)Authors: Farwell, Lawrence A.; Richardson, Drew C.; Richardson, Graham M.; Furedy, John J.;Farwell, Lawrence A.; Richardson, Drew C.; Richardson, Graham M.; Furedy, John J.;A classification concealed information test (CIT) used the “brain fingerprinting” method of applying P300 event-related potential (ERP) in detecting information that is (1) acquired in real life and (2) unique to US Navy experts in military medicine. Military medicine experts and non-experts were asked to push buttons in response to three types of text stimuli. Targets contain known information relevant to military medicine, are identified to subjects as relevant, and require pushing one button. Subjects are told to push another button to all other stimuli. Probes contain concealed information relevant to military medicine, and are not identified to subjects. Irrelevants contain equally plausible, but incorrect/irrelevant information. Error rate was 0%. Median and mean statistical confidences for individual determinations were 99.9% with no indeterminates (results lacking sufficiently high statistical confidence to be classified). We compared error rate and statistical confidence for determinations of both information present and information absent produced by classification CIT (Is a probe ERP more similar to a target or to an irrelevant ERP?) vs. comparison CIT (Does a probe produce a larger ERP than an irrelevant?) using P300 plus the late negative component (LNP; together, P300-MERMER). Comparison CIT produced a significantly higher error rate (20%) and lower statistical confidences: mean 67%; information-absent mean was 28.9%, less than chance (50%). We compared analysis using P300 alone with the P300 + LNP. P300 alone produced the same 0% error rate but significantly lower statistical confidences. These findings add to the evidence that the brain fingerprinting methods as described here provide sufficient conditions to produce less than 1% error rate and greater than 95% median statistical confidence in a CIT on information obtained in the course of real life that is characteristic of individuals with specific training, expertise, or organizational affiliation.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4274905Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4274905Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnins.2014.00410&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Elsevier BV Funded by:NIH | Cortical plasticity in ty..., NIH | Treating hyperexcitabilit..., NIH | Cortical connectivity, ph... +8 projectsNIH| Cortical plasticity in type II diabetes mellitus ,NIH| Treating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognition ,NIH| Cortical connectivity, physiology, and response to stimulation in human epilepsy ,NIH| Gamma Induction for Amyloid Clearance in Alzheimer’s Disease ,NIH| The Development and Human Translation of Temporal Interference Brain Stimulation ,NIH| Transcranial Stimulation in Spino-Cerebellar Ataxia ,NIH| Role of functional brain connectivity on efficacy of TMS for depression ,NIH| Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke ,NIH| Harvard Clinical and Translational Science Center (UL1) ,NIH| Reliability of Repetitive TMS-induced Modulation of Cortical Excitability ,NIH| INTERDISCIPLINARY STUDY OF DELIRIUM AND ITS LONG-TERM OUTCOMESRecep Ali Ozdemir; Ehsan Tadayon; Pierre Boucher; Haoqi Sun; Davide Momi; Wolfgang Ganglberger; M. Brandon Westover; Alvaro Pascual-Leone; Emiliano Santarnecchi; Mouhsin M. Shafi;Abstract Background In recent years, it has become increasingly apparent that characterizing individual brain structure, connectivity and dynamics is essential for understanding brain function in health and disease. However, the majority of neuroimaging and brain stimulation research has characterized human brain function by averaging measurements from groups of subjects and providing population-level inferences. External perturbations applied directly to well-defined brain regions can reveal distinctive information about the state, connectivity and dynamics of the human brain at the individual level. Objectives In a series of studies, we aimed to characterize individual brain responses to MRI-guided transcranial magnetic stimulation (TMS), and explore the reproducibility of the evoked effects, differences between brain regions, and their individual specificity. Methods In the first study, we administered single pulses of TMS to both anatomically (left dorsolateral prefrontal cortex- ‘L-DLPFC’, left Intra-parietal lobule- ‘L-IPL) and functionally (left motor cortex- ‘L-M1’, right default mode network- ‘R-DMN, right dorsal attention network- ‘R-DAN’) defined cortical nodes in the frontal, motor, and parietal regions across two identical sessions spaced one month apart in 24 healthy volunteers. In the second study, we extended our analyses to two independent data sets (n = 10 in both data sets) having different sham-TMS protocols. Results In the first study, we found that perturbation-induced cortical propagation patterns are heterogeneous across individuals but highly reproducible within individuals, specific to the stimulated region, and distinct from spontaneous activity. Most importantly, we demonstrate that by assessing the spatiotemporal characteristics of TMS-induced brain responses originating from different cortical regions, individual subjects can be identified with perfect accuracy. In the second study, we demonstrated that subject specificity of TEPs is generalizable across independent data sets and distinct from non-transcranial neural responses evoked by sham-TMS protocols. Conclusions Perturbation-induced brain responses reveal unique “brain fingerprints” that reflect causal connectivity dynamics of the stimulated brain regions, and may serve as reliable biomarkers of individual brain function.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8108003Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brs.2021.02.005&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 33 citations 33 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8108003Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brs.2021.02.005&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2014Publisher:Frontiers Media SA Funded by:NWO | Microbial support of plan...NWO| Microbial support of plant growth under abiotic stress (project 3)Authors: Farwell, Lawrence A.; Richardson, Drew C.; Richardson, Graham M.; Furedy, John J.;Farwell, Lawrence A.; Richardson, Drew C.; Richardson, Graham M.; Furedy, John J.;A classification concealed information test (CIT) used the “brain fingerprinting” method of applying P300 event-related potential (ERP) in detecting information that is (1) acquired in real life and (2) unique to US Navy experts in military medicine. Military medicine experts and non-experts were asked to push buttons in response to three types of text stimuli. Targets contain known information relevant to military medicine, are identified to subjects as relevant, and require pushing one button. Subjects are told to push another button to all other stimuli. Probes contain concealed information relevant to military medicine, and are not identified to subjects. Irrelevants contain equally plausible, but incorrect/irrelevant information. Error rate was 0%. Median and mean statistical confidences for individual determinations were 99.9% with no indeterminates (results lacking sufficiently high statistical confidence to be classified). We compared error rate and statistical confidence for determinations of both information present and information absent produced by classification CIT (Is a probe ERP more similar to a target or to an irrelevant ERP?) vs. comparison CIT (Does a probe produce a larger ERP than an irrelevant?) using P300 plus the late negative component (LNP; together, P300-MERMER). Comparison CIT produced a significantly higher error rate (20%) and lower statistical confidences: mean 67%; information-absent mean was 28.9%, less than chance (50%). We compared analysis using P300 alone with the P300 + LNP. P300 alone produced the same 0% error rate but significantly lower statistical confidences. These findings add to the evidence that the brain fingerprinting methods as described here provide sufficient conditions to produce less than 1% error rate and greater than 95% median statistical confidence in a CIT on information obtained in the course of real life that is characteristic of individuals with specific training, expertise, or organizational affiliation.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4274905Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnins.2014.00410&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4274905Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fnins.2014.00410&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 SpainPublisher:Elsevier BV Funded by:NIH | Cortical plasticity in ty..., NIH | Treating hyperexcitabilit..., NIH | Cortical connectivity, ph... +8 projectsNIH| Cortical plasticity in type II diabetes mellitus ,NIH| Treating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognition ,NIH| Cortical connectivity, physiology, and response to stimulation in human epilepsy ,NIH| Gamma Induction for Amyloid Clearance in Alzheimer’s Disease ,NIH| The Development and Human Translation of Temporal Interference Brain Stimulation ,NIH| Transcranial Stimulation in Spino-Cerebellar Ataxia ,NIH| Role of functional brain connectivity on efficacy of TMS for depression ,NIH| Transcranial Direct Current Stimulation and Robotic Training in Chronic Stroke ,NIH| Harvard Clinical and Translational Science Center (UL1) ,NIH| Reliability of Repetitive TMS-induced Modulation of Cortical Excitability ,NIH| INTERDISCIPLINARY STUDY OF DELIRIUM AND ITS LONG-TERM OUTCOMESRecep Ali Ozdemir; Ehsan Tadayon; Pierre Boucher; Haoqi Sun; Davide Momi; Wolfgang Ganglberger; M. Brandon Westover; Alvaro Pascual-Leone; Emiliano Santarnecchi; Mouhsin M. Shafi;Abstract Background In recent years, it has become increasingly apparent that characterizing individual brain structure, connectivity and dynamics is essential for understanding brain function in health and disease. However, the majority of neuroimaging and brain stimulation research has characterized human brain function by averaging measurements from groups of subjects and providing population-level inferences. External perturbations applied directly to well-defined brain regions can reveal distinctive information about the state, connectivity and dynamics of the human brain at the individual level. Objectives In a series of studies, we aimed to characterize individual brain responses to MRI-guided transcranial magnetic stimulation (TMS), and explore the reproducibility of the evoked effects, differences between brain regions, and their individual specificity. Methods In the first study, we administered single pulses of TMS to both anatomically (left dorsolateral prefrontal cortex- ‘L-DLPFC’, left Intra-parietal lobule- ‘L-IPL) and functionally (left motor cortex- ‘L-M1’, right default mode network- ‘R-DMN, right dorsal attention network- ‘R-DAN’) defined cortical nodes in the frontal, motor, and parietal regions across two identical sessions spaced one month apart in 24 healthy volunteers. In the second study, we extended our analyses to two independent data sets (n = 10 in both data sets) having different sham-TMS protocols. Results In the first study, we found that perturbation-induced cortical propagation patterns are heterogeneous across individuals but highly reproducible within individuals, specific to the stimulated region, and distinct from spontaneous activity. Most importantly, we demonstrate that by assessing the spatiotemporal characteristics of TMS-induced brain responses originating from different cortical regions, individual subjects can be identified with perfect accuracy. In the second study, we demonstrated that subject specificity of TEPs is generalizable across independent data sets and distinct from non-transcranial neural responses evoked by sham-TMS protocols. Conclusions Perturbation-induced brain responses reveal unique “brain fingerprints” that reflect causal connectivity dynamics of the stimulated brain regions, and may serve as reliable biomarkers of individual brain function.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8108003Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brs.2021.02.005&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 33 citations 33 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8108003Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTARecolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.brs.2021.02.005&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu