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31,820 Research products, page 1 of 3,182

  • Neuroinformatics

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  • Publication . Conference object . Article . 2005
    Authors: 
    A.C.G. Almeida; A.F.C. Infantosi;
    Publisher: IEEE
  • Publication . Doctoral thesis . Other literature type . 2005
    Open Access English
    Authors: 
    Viceic, Dragana;
    Publisher: Université de Lausanne, Faculté de biologie et médecine

    Le développement rapide de nouvelles technologies comme l’imagerie médicale a permis l’expansion des études sur les fonctions cérébrales. Le rôle principal des études fonctionnelles cérébrales est de comparer l’activation neuronale entre différents individus. Dans ce contexte, la variabilité anatomique de la taille et de la forme du cerveau pose un problème majeur. Les méthodes actuelles permettent les comparaisons interindividuelles par la normalisation des cerveaux en utilisant un cerveau standard. Les cerveaux standards les plus utilisés actuellement sont le cerveau de Talairach et le cerveau de l’Institut Neurologique de Montréal (MNI) (SPM99). Les méthodes de recalage qui utilisent le cerveau de Talairach, ou celui de MNI, ne sont pas suffisamment précises pour superposer les parties plus variable d’un cortex cérébral (p.ex., le néocortex ou la zone perisylvienne), ainsi que les régions qui ont une asymétrie très importante entre les deux hémisphères. Le but de ce projet est d’évaluer une nouvelle technique de traitement d’images basée sur le recalage non-rigide et utilisant les repères anatomiques. Tout d’abord, nous devons identifier et extraire les structures anatomiques (les repères anatomiques) dans le cerveau à déformer et celui de référence. La correspondance entre ces deux jeux de repères nous permet de déterminer en 3D la déformation appropriée. Pour les repères anatomiques, nous utilisons six points de contrôle qui sont situés : un sur le gyrus de Heschl, un sur la zone motrice de la main et le dernier sur la fissure sylvienne, bilatéralement. Evaluation de notre programme de recalage est accomplie sur les images d’IRM et d’IRMf de neuf sujets parmi dix-huit qui ont participés dans une étude précédente de Maeder et al. Le résultat sur les images anatomiques, IRM, montre le déplacement des repères anatomiques du cerveau à déformer à la position des repères anatomiques de cerveau de référence. La distance du cerveau à déformer par rapport au cerveau de référence diminue après le recalage. Le recalage des images fonctionnelles, IRMf, ne montre pas de variation significative. Le petit nombre de repères, six points de contrôle, n’est pas suffisant pour produire les modifications des cartes statistiques. Cette thèse ouvre la voie à une nouvelle technique de recalage du cortex cérébral dont la direction principale est le recalage de plusieurs points représentant un sillon cérébral. The fast development of new technologies such as digital medical imaging brought to the expansion of brain functional studies. One of the methodolgical key issue in brain functional studies is to compare neuronal activation between individuals. In this context, the great variability of brain size and shape is a major problem. Current methods allow inter-individual comparisions by means of normalisation of subjects’ brains in relation to a standard brain. A largerly used standard brains are the proportional grid of Talairach and Tournoux and the Montreal Neurological Insititute standard brain (SPM99). However, there is a lack of more precise methods for the superposition of more variable portions of the cerebral cortex (e.g, neocrotex and perisyvlian zone) and in brain regions highly asymmetric between the two cerebral hemipsheres (e.g. planum termporale). The aim of this thesis is to evaluate a new image processing technique based on non-linear model-based registration. Contrary to the intensity-based, model-based registration uses spatial and not intensitiy information to fit one image to another. We extract identifiable anatomical features (point landmarks) in both deforming and target images and by their correspondence we determine the appropriate deformation in 3D. As landmarks, we use six control points that are situated: one on the Heschl’y Gyrus, one on the motor hand area, and one on the sylvian fissure, bilaterally. The evaluation of this model-based approach is performed on MRI and fMRI images of nine of eighteen subjects participating in the Maeder et al. study. Results on anatomical, i.e. MRI, images, show the mouvement of the deforming brain control points to the location of the reference brain control points. The distance of the deforming brain to the reference brain is smallest after the registration compared to the distance before the registration. Registration of functional images, i.e fMRI, doesn’t show a significant variation. The small number of registration landmarks, i.e. six, is obvious not sufficient to produce significant modification on the fMRI statistical maps. This thesis opens the way to a new computation technique for cortex registration in which the main directions will be improvement of the registation algorithm, using not only one point as landmark, but many points, representing one particular sulcus.

  • Open Access English
    Authors: 
    Shimaoka, Shigeyoshi; Hamaoka, Hitomi; Inoue, Junji; Asanuma, Masato; Tooyama, Ikuo; Kondo, Yoichi;
    Publisher: Okayama University Medical School

    Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS.

  • Publication . Part of book or chapter of book . 2004
    Authors: 
    Michael E. Charness; Gottfried Schlaug;
    Publisher: PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.
  • Research data . 2021
    Open Access
    Authors: 
    Chen, Xiaoyin;
    Publisher: Mendeley

    BARseq2 in M1 and A1. Including processed projection data, in situ sequencing data, and analysis scripts. Also include helper files needed to run the scripts. Accompanying Sun et al., 2021 Nat Neurosci

  • Publication . 2011
    Open Access English
    Authors: 
    Watson, Charles;
    Publisher: The University of Sydney
    Country: Australia

    These publications are a summary of work I have completed in brain mapping over many years. The work includes one book (The Rat Brain in Stereotaxic Coordinates, 6th compact edition), ten articles on hindbrain and spinal cord anatomy published in peer reviewed journals between 1975 to 2011, and five published chapters on spinal cord anatomy, including two spinal cord atlases. Over my career I have published 15 books on the anatomy of the brain and spinal cord of experimental animals. I am first author or equal co-author of ten of these books. The most successful of these books, "The Rat Brain in Stereotaxic Coordinates" (Paxinos and Watson, l 982, 1986, 1996, 1998, 2005, 2007), has earned over 50,000 citations since it was first published in 1982. The second edition alone is ranked 32 in the Thomson ISI 50 most cited publications of all time, having been cited 17,093 times up to January 2006. Dr George Paxinos and l are equal contributors to this work; the order of authors was decided on alphabetical precedence.

  • Publication . Part of book or chapter of book . 2005
    Authors: 
    Kathleen M. Thomas; B. J. Casey;
    Publisher: Psychology Press
  • Publication . Part of book or chapter of book . 2010
    Closed Access
    Authors: 
    José Luis Bermúdez;
    Publisher: Cambridge University Press
  • Closed Access English
    Authors: 
    Carmela Sindorio; Maria Quattropani; Giovanni Raffa; Antonino Scibilia; Alfredo Conti; Antonino Germanò;
    Publisher: country:ITA
    Country: Italy

    preoperative neurocognitive assessment for cortical cognitive mapping: one size doesn't fit all

  • Authors: 
    Barry Horwitz; Silvina G. Horovitz;
    Publisher: Frontiers Media SA
Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Subject
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to Neuroinformatics. Are you interested to view more results? Visit OpenAIRE - Explore.
31,820 Research products, page 1 of 3,182
  • Publication . Conference object . Article . 2005
    Authors: 
    A.C.G. Almeida; A.F.C. Infantosi;
    Publisher: IEEE
  • Publication . Doctoral thesis . Other literature type . 2005
    Open Access English
    Authors: 
    Viceic, Dragana;
    Publisher: Université de Lausanne, Faculté de biologie et médecine

    Le développement rapide de nouvelles technologies comme l’imagerie médicale a permis l’expansion des études sur les fonctions cérébrales. Le rôle principal des études fonctionnelles cérébrales est de comparer l’activation neuronale entre différents individus. Dans ce contexte, la variabilité anatomique de la taille et de la forme du cerveau pose un problème majeur. Les méthodes actuelles permettent les comparaisons interindividuelles par la normalisation des cerveaux en utilisant un cerveau standard. Les cerveaux standards les plus utilisés actuellement sont le cerveau de Talairach et le cerveau de l’Institut Neurologique de Montréal (MNI) (SPM99). Les méthodes de recalage qui utilisent le cerveau de Talairach, ou celui de MNI, ne sont pas suffisamment précises pour superposer les parties plus variable d’un cortex cérébral (p.ex., le néocortex ou la zone perisylvienne), ainsi que les régions qui ont une asymétrie très importante entre les deux hémisphères. Le but de ce projet est d’évaluer une nouvelle technique de traitement d’images basée sur le recalage non-rigide et utilisant les repères anatomiques. Tout d’abord, nous devons identifier et extraire les structures anatomiques (les repères anatomiques) dans le cerveau à déformer et celui de référence. La correspondance entre ces deux jeux de repères nous permet de déterminer en 3D la déformation appropriée. Pour les repères anatomiques, nous utilisons six points de contrôle qui sont situés : un sur le gyrus de Heschl, un sur la zone motrice de la main et le dernier sur la fissure sylvienne, bilatéralement. Evaluation de notre programme de recalage est accomplie sur les images d’IRM et d’IRMf de neuf sujets parmi dix-huit qui ont participés dans une étude précédente de Maeder et al. Le résultat sur les images anatomiques, IRM, montre le déplacement des repères anatomiques du cerveau à déformer à la position des repères anatomiques de cerveau de référence. La distance du cerveau à déformer par rapport au cerveau de référence diminue après le recalage. Le recalage des images fonctionnelles, IRMf, ne montre pas de variation significative. Le petit nombre de repères, six points de contrôle, n’est pas suffisant pour produire les modifications des cartes statistiques. Cette thèse ouvre la voie à une nouvelle technique de recalage du cortex cérébral dont la direction principale est le recalage de plusieurs points représentant un sillon cérébral. The fast development of new technologies such as digital medical imaging brought to the expansion of brain functional studies. One of the methodolgical key issue in brain functional studies is to compare neuronal activation between individuals. In this context, the great variability of brain size and shape is a major problem. Current methods allow inter-individual comparisions by means of normalisation of subjects’ brains in relation to a standard brain. A largerly used standard brains are the proportional grid of Talairach and Tournoux and the Montreal Neurological Insititute standard brain (SPM99). However, there is a lack of more precise methods for the superposition of more variable portions of the cerebral cortex (e.g, neocrotex and perisyvlian zone) and in brain regions highly asymmetric between the two cerebral hemipsheres (e.g. planum termporale). The aim of this thesis is to evaluate a new image processing technique based on non-linear model-based registration. Contrary to the intensity-based, model-based registration uses spatial and not intensitiy information to fit one image to another. We extract identifiable anatomical features (point landmarks) in both deforming and target images and by their correspondence we determine the appropriate deformation in 3D. As landmarks, we use six control points that are situated: one on the Heschl’y Gyrus, one on the motor hand area, and one on the sylvian fissure, bilaterally. The evaluation of this model-based approach is performed on MRI and fMRI images of nine of eighteen subjects participating in the Maeder et al. study. Results on anatomical, i.e. MRI, images, show the mouvement of the deforming brain control points to the location of the reference brain control points. The distance of the deforming brain to the reference brain is smallest after the registration compared to the distance before the registration. Registration of functional images, i.e fMRI, doesn’t show a significant variation. The small number of registration landmarks, i.e. six, is obvious not sufficient to produce significant modification on the fMRI statistical maps. This thesis opens the way to a new computation technique for cortex registration in which the main directions will be improvement of the registation algorithm, using not only one point as landmark, but many points, representing one particular sulcus.

  • Open Access English
    Authors: 
    Shimaoka, Shigeyoshi; Hamaoka, Hitomi; Inoue, Junji; Asanuma, Masato; Tooyama, Ikuo; Kondo, Yoichi;
    Publisher: Okayama University Medical School

    Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS.

  • Publication . Part of book or chapter of book . 2004
    Authors: 
    Michael E. Charness; Gottfried Schlaug;
    Publisher: PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.
  • Research data . 2021
    Open Access
    Authors: 
    Chen, Xiaoyin;
    Publisher: Mendeley

    BARseq2 in M1 and A1. Including processed projection data, in situ sequencing data, and analysis scripts. Also include helper files needed to run the scripts. Accompanying Sun et al., 2021 Nat Neurosci

  • Publication . 2011
    Open Access English
    Authors: 
    Watson, Charles;
    Publisher: The University of Sydney
    Country: Australia

    These publications are a summary of work I have completed in brain mapping over many years. The work includes one book (The Rat Brain in Stereotaxic Coordinates, 6th compact edition), ten articles on hindbrain and spinal cord anatomy published in peer reviewed journals between 1975 to 2011, and five published chapters on spinal cord anatomy, including two spinal cord atlases. Over my career I have published 15 books on the anatomy of the brain and spinal cord of experimental animals. I am first author or equal co-author of ten of these books. The most successful of these books, "The Rat Brain in Stereotaxic Coordinates" (Paxinos and Watson, l 982, 1986, 1996, 1998, 2005, 2007), has earned over 50,000 citations since it was first published in 1982. The second edition alone is ranked 32 in the Thomson ISI 50 most cited publications of all time, having been cited 17,093 times up to January 2006. Dr George Paxinos and l are equal contributors to this work; the order of authors was decided on alphabetical precedence.

  • Publication . Part of book or chapter of book . 2005
    Authors: 
    Kathleen M. Thomas; B. J. Casey;
    Publisher: Psychology Press
  • Publication . Part of book or chapter of book . 2010
    Closed Access
    Authors: 
    José Luis Bermúdez;
    Publisher: Cambridge University Press
  • Closed Access English
    Authors: 
    Carmela Sindorio; Maria Quattropani; Giovanni Raffa; Antonino Scibilia; Alfredo Conti; Antonino Germanò;
    Publisher: country:ITA
    Country: Italy

    preoperative neurocognitive assessment for cortical cognitive mapping: one size doesn't fit all

  • Authors: 
    Barry Horwitz; Silvina G. Horovitz;
    Publisher: Frontiers Media SA