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- Publication . Other literature type . 2008Closed Access EnglishAuthors:Judaš, Miloš;Judaš, Miloš;Country: Croatia
ABSTRACT
- Publication . Other literature type . 2008Closed Access EnglishAuthors:Judaš, Miloš;Judaš, Miloš;Country: Croatia
ABSTRACT
- Publication . Other literature type . 2012EnglishAuthors:Biggs, Laura Ashley Filimon;Biggs, Laura Ashley Filimon;Publisher: University of Utah
Periventricular leukomalacia (PVL) occurs in pre-term infants and is often the result of a cerebral hypoxic-ischemic (HI) insult. PVL is characterized by white matter damage, a significantly increased risk of epilepsy, mental retardation, and/or cerebral palsy. A rat pup model of PVL has been used to characterize the susceptibility of the neonatal brain to hypoxia-ischemia-induced brain damage. The experiments conducted in this dissertation tested the hypothesis that HI results in sustained myelin basic protein (MBP) reductions, altered brain morphology, motor deficits and that levetiracetam, zonisamide, and/or lamotrigine may have potential efficacy as neuroprotective agents against HI induced brain damage and associated motor deficits. It remains unclear whether the damage observed at P7 persists into adulthood. Therefore, Specific Aim 1 will characterize Hl-induced effect on MBP and ventricular size at PI 1, P21 and P60. While, specific Aim 2 will characterize long-term motor deficits at P21 and P60. In addition, rats exposed to HI at P7 exhibit contralateral motor deficits at P21. Pharmacological intervention post-HI, using topiramate, is able to normalize both preoligodendrocyte cell loss and the motor deficit. Therefore, Specific aim 3 will assess the protective effects of topiramate, levetiracetam, zonisamide, and lamotrigine on HIinduced MBP lesions at P11 and motor deficits at P21.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2007Closed AccessAuthors:T.E. Inder;T.E. Inder;Publisher: Elsevier BVAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 2021Open AccessAuthors:Ritsuko K. Pooh;Ritsuko K. Pooh;Publisher: CRC PressAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Book . 2004Closed AccessAuthors:Catherine Garel;Catherine Garel;Publisher: Springer Berlin HeidelbergAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 1991Authors:Joseph Palca;Joseph Palca;Publisher: American Association for the Advancement of Science (AAAS)Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 2016Authors:Kazuo Maeda;Kazuo Maeda;Publisher: Jaypee Brothers Medical Publishers (P) Ltd.Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 1988Authors:Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;Publisher: Springer US
The recovery from brain injuring has recently been obtained using the fetal brain transplant technique in adult mammal brains. Thus, it has been established that transplanted neurons differentiate and make connections with the host brain (Frotscher and Zimmer, 1986). Moreover, there are studies that have been able to show biochemical and functional changes due to such transplants (Bjorklund and Stenevi, 1977; Drucker-Colin et al, 1984). Up until recently, some studies have shown cognitive function recuperation (Bjorklund and Stenevi, 1985; Dunnett et al, 1985).
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Authors:Emmet Hirsch;Emmet Hirsch;Publisher: American Medical Association (AMA)Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.
1,267 Research products, page 1 of 127
Loading
- Publication . Other literature type . 2008Closed Access EnglishAuthors:Judaš, Miloš;Judaš, Miloš;Country: Croatia
ABSTRACT
- Publication . Other literature type . 2008Closed Access EnglishAuthors:Judaš, Miloš;Judaš, Miloš;Country: Croatia
ABSTRACT
- Publication . Other literature type . 2012EnglishAuthors:Biggs, Laura Ashley Filimon;Biggs, Laura Ashley Filimon;Publisher: University of Utah
Periventricular leukomalacia (PVL) occurs in pre-term infants and is often the result of a cerebral hypoxic-ischemic (HI) insult. PVL is characterized by white matter damage, a significantly increased risk of epilepsy, mental retardation, and/or cerebral palsy. A rat pup model of PVL has been used to characterize the susceptibility of the neonatal brain to hypoxia-ischemia-induced brain damage. The experiments conducted in this dissertation tested the hypothesis that HI results in sustained myelin basic protein (MBP) reductions, altered brain morphology, motor deficits and that levetiracetam, zonisamide, and/or lamotrigine may have potential efficacy as neuroprotective agents against HI induced brain damage and associated motor deficits. It remains unclear whether the damage observed at P7 persists into adulthood. Therefore, Specific Aim 1 will characterize Hl-induced effect on MBP and ventricular size at PI 1, P21 and P60. While, specific Aim 2 will characterize long-term motor deficits at P21 and P60. In addition, rats exposed to HI at P7 exhibit contralateral motor deficits at P21. Pharmacological intervention post-HI, using topiramate, is able to normalize both preoligodendrocyte cell loss and the motor deficit. Therefore, Specific aim 3 will assess the protective effects of topiramate, levetiracetam, zonisamide, and lamotrigine on HIinduced MBP lesions at P11 and motor deficits at P21.
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2007Closed AccessAuthors:T.E. Inder;T.E. Inder;Publisher: Elsevier BVAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 2021Open AccessAuthors:Ritsuko K. Pooh;Ritsuko K. Pooh;Publisher: CRC PressAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Book . 2004Closed AccessAuthors:Catherine Garel;Catherine Garel;Publisher: Springer Berlin HeidelbergAverage popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 1991Authors:Joseph Palca;Joseph Palca;Publisher: American Association for the Advancement of Science (AAAS)Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 2016Authors:Kazuo Maeda;Kazuo Maeda;Publisher: Jaypee Brothers Medical Publishers (P) Ltd.Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Part of book or chapter of book . 1988Authors:Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;Publisher: Springer US
The recovery from brain injuring has recently been obtained using the fetal brain transplant technique in adult mammal brains. Thus, it has been established that transplanted neurons differentiate and make connections with the host brain (Frotscher and Zimmer, 1986). Moreover, there are studies that have been able to show biochemical and functional changes due to such transplants (Bjorklund and Stenevi, 1977; Drucker-Colin et al, 1984). Up until recently, some studies have shown cognitive function recuperation (Bjorklund and Stenevi, 1985; Dunnett et al, 1985).
Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product. - Publication . Article . 2019Authors:Emmet Hirsch;Emmet Hirsch;Publisher: American Medical Association (AMA)Average popularityAverage popularity In bottom 99%Average influencePopularity: Citation-based measure reflecting the current impact.Average influence In bottom 99%Influence: Citation-based measure reflecting the total impact.
add Add to ORCIDPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.