Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Subject
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to Neuroinformatics. Are you interested to view more results? Visit OpenAIRE - Explore.
1,267 Research products, page 1 of 127

  • Neuroinformatics

10
arrow_drop_down
Relevance
arrow_drop_down
  • Publication . Other literature type . 2008
    Closed Access English
    Authors: 
    Judaš, Miloš;
    Country: Croatia

    ABSTRACT

  • Publication . Other literature type . 2008
    Closed Access English
    Authors: 
    Judaš, Miloš;
    Country: Croatia

    ABSTRACT

  • English
    Authors: 
    Biggs, Laura Ashley Filimon;
    Publisher: University of Utah

    Periventricular leukomalacia (PVL) occurs in pre-term infants and is often the result of a cerebral hypoxic-ischemic (HI) insult. PVL is characterized by white matter damage, a significantly increased risk of epilepsy, mental retardation, and/or cerebral palsy. A rat pup model of PVL has been used to characterize the susceptibility of the neonatal brain to hypoxia-ischemia-induced brain damage. The experiments conducted in this dissertation tested the hypothesis that HI results in sustained myelin basic protein (MBP) reductions, altered brain morphology, motor deficits and that levetiracetam, zonisamide, and/or lamotrigine may have potential efficacy as neuroprotective agents against HI induced brain damage and associated motor deficits. It remains unclear whether the damage observed at P7 persists into adulthood. Therefore, Specific Aim 1 will characterize Hl-induced effect on MBP and ventricular size at PI 1, P21 and P60. While, specific Aim 2 will characterize long-term motor deficits at P21 and P60. In addition, rats exposed to HI at P7 exhibit contralateral motor deficits at P21. Pharmacological intervention post-HI, using topiramate, is able to normalize both preoligodendrocyte cell loss and the motor deficit. Therefore, Specific aim 3 will assess the protective effects of topiramate, levetiracetam, zonisamide, and lamotrigine on HIinduced MBP lesions at P11 and motor deficits at P21.

  • Closed Access
    Authors: 
    T.E. Inder;
    Publisher: Elsevier BV
  • Publication . Part of book or chapter of book . 2021
    Open Access
    Authors: 
    Ritsuko K. Pooh;
    Publisher: CRC Press
  • Publication . Book . 2004
    Closed Access
    Authors: 
    Catherine Garel;
    Publisher: Springer Berlin Heidelberg
  • Publication . Article . 1991
    Authors: 
    Joseph Palca;
    Publisher: American Association for the Advancement of Science (AAAS)
  • Publication . Part of book or chapter of book . 2016
    Authors: 
    Kazuo Maeda;
    Publisher: Jaypee Brothers Medical Publishers (P) Ltd.
  • Authors: 
    Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;
    Publisher: Springer US

    The recovery from brain injuring has recently been obtained using the fetal brain transplant technique in adult mammal brains. Thus, it has been established that transplanted neurons differentiate and make connections with the host brain (Frotscher and Zimmer, 1986). Moreover, there are studies that have been able to show biochemical and functional changes due to such transplants (Bjorklund and Stenevi, 1977; Drucker-Colin et al, 1984). Up until recently, some studies have shown cognitive function recuperation (Bjorklund and Stenevi, 1985; Dunnett et al, 1985).

  • Authors: 
    Emmet Hirsch;
    Publisher: American Medical Association (AMA)
Advanced search in Research products
Research products
arrow_drop_down
Searching FieldsTerms
Subject
arrow_drop_down
includes
arrow_drop_down
Include:
The following results are related to Neuroinformatics. Are you interested to view more results? Visit OpenAIRE - Explore.
1,267 Research products, page 1 of 127
  • Publication . Other literature type . 2008
    Closed Access English
    Authors: 
    Judaš, Miloš;
    Country: Croatia

    ABSTRACT

  • Publication . Other literature type . 2008
    Closed Access English
    Authors: 
    Judaš, Miloš;
    Country: Croatia

    ABSTRACT

  • English
    Authors: 
    Biggs, Laura Ashley Filimon;
    Publisher: University of Utah

    Periventricular leukomalacia (PVL) occurs in pre-term infants and is often the result of a cerebral hypoxic-ischemic (HI) insult. PVL is characterized by white matter damage, a significantly increased risk of epilepsy, mental retardation, and/or cerebral palsy. A rat pup model of PVL has been used to characterize the susceptibility of the neonatal brain to hypoxia-ischemia-induced brain damage. The experiments conducted in this dissertation tested the hypothesis that HI results in sustained myelin basic protein (MBP) reductions, altered brain morphology, motor deficits and that levetiracetam, zonisamide, and/or lamotrigine may have potential efficacy as neuroprotective agents against HI induced brain damage and associated motor deficits. It remains unclear whether the damage observed at P7 persists into adulthood. Therefore, Specific Aim 1 will characterize Hl-induced effect on MBP and ventricular size at PI 1, P21 and P60. While, specific Aim 2 will characterize long-term motor deficits at P21 and P60. In addition, rats exposed to HI at P7 exhibit contralateral motor deficits at P21. Pharmacological intervention post-HI, using topiramate, is able to normalize both preoligodendrocyte cell loss and the motor deficit. Therefore, Specific aim 3 will assess the protective effects of topiramate, levetiracetam, zonisamide, and lamotrigine on HIinduced MBP lesions at P11 and motor deficits at P21.

  • Closed Access
    Authors: 
    T.E. Inder;
    Publisher: Elsevier BV
  • Publication . Part of book or chapter of book . 2021
    Open Access
    Authors: 
    Ritsuko K. Pooh;
    Publisher: CRC Press
  • Publication . Book . 2004
    Closed Access
    Authors: 
    Catherine Garel;
    Publisher: Springer Berlin Heidelberg
  • Publication . Article . 1991
    Authors: 
    Joseph Palca;
    Publisher: American Association for the Advancement of Science (AAAS)
  • Publication . Part of book or chapter of book . 2016
    Authors: 
    Kazuo Maeda;
    Publisher: Jaypee Brothers Medical Publishers (P) Ltd.
  • Authors: 
    Federico Bermúdez-Rattoni; Juan Carlos Fernández; Martha L. Escobar;
    Publisher: Springer US

    The recovery from brain injuring has recently been obtained using the fetal brain transplant technique in adult mammal brains. Thus, it has been established that transplanted neurons differentiate and make connections with the host brain (Frotscher and Zimmer, 1986). Moreover, there are studies that have been able to show biochemical and functional changes due to such transplants (Bjorklund and Stenevi, 1977; Drucker-Colin et al, 1984). Up until recently, some studies have shown cognitive function recuperation (Bjorklund and Stenevi, 1985; Dunnett et al, 1985).

  • Authors: 
    Emmet Hirsch;
    Publisher: American Medical Association (AMA)