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  • Authors: P, DURAND; C, ZUNIN;
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  • Authors: R, Walbaum; M F, Van de Velde-Staquet; J, Bahon-Le Capon; B, Boudiguet; +3 Authors
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  • Authors: I, Murano;
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  • Authors: W, DeMyer;

    Brain malformations have been classified on the basis of the types of errors which occur during embryologic development. The basis of the classification is the level of formative pathogenesis at which the error occurs. Development can be artificially regarded as consisting of cytogenesis, histogenesis, and organogenesis. Although the final stage of a malformation can be classified under one of these headings, the categories are not mutually exclusive. The classification is given in the form of a dendrogram which permits any further degree of specificity or subdivision desired.

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  • Authors: Jones, Sharon Marie;

    The purpose of this study was to document a normal range of measures observed in cranial transillumination obtained from testing neurologically intact full-term infants. Ranges, means, and standards deviations in millimeters of transilluminated light of five regions of the skull, i.e., anterior fontanel, frontal midline, left biparietal, right biparietal, and occipital midline regions, were determined. Additional variables, e.g. molding, age when tested, sex, birth weight, type of delivery, head circumference, and size of the anterior fontanel, were analyzed to ascertain if there was any relationship between these variables and the amount of light transilluminated. The study was conducted at the Latter-day Saints Hospital during a 3-week time period. Forty-seven infants were tested between the twenty -fourth and seventy-second hours of life. Parental informed consent was obtained prior to conducting the transillumination procedure. The data were analyzed through the University of Utah Computer Center utilizing a Univac computer. A breakdown program and P Pearson product-moment correlation coefficient were obtained. More light was observed in the anterior fontanel and frontal midline regions than the biparietal areas and more in the biparietal areas than the occipital areas. Generally, the amount of transilluminated light seemed to decrease from the anterior to posterior regions of the head when suture lines were open or adjacent. When the sagittal suture line was overriding there was an increase in the amount of transillumination observed in the frontal midline area. Total transilluminated light, i.e., the sum of the millimeter reading for the five skull areas, was also considered for each infant. The mean was 30.02 millimeters. Standard deviation was 5.77 millimeters. Thirty-one infants scored in this range. Fourteen infants scored in the second standard deviation. Two infants scored above the second standard deviation. These infants were presented. Increasing amounts of light were noted in infants tested from 24 to 37 hours of age, then the amount of transilluminated light showed a slight decline. This trend should be further investigated. Problems and concerns noted during the study as well a recommendations and implications for future research in this areas were discussed.

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  • Authors: H, Bitran; E, Weinhouse; M, Grief; H, Zirkin;
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  • Authors: G J, MELOT; A, PEETRONS; P, GILLET;
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Flaminia Vena; Lucia Manganaro; Valentina D’Ambrosio; Luisa Masciullo; +9 Authors

    Background: Congenital heart diseases (CHDs) are often associated with significant neurocognitive impairment and neurological delay. This study aims to elucidate the correlation between type of CHD and Doppler velocimetry and to investigate the possible presence of fetal brain abnormalities identified by magnetic resonance imaging (MRI). Methods: From July 2010 to July 2020, we carried out a cross-sectional study of 63 singleton pregnancies with a diagnosis of different types of complex CHD: LSOL (left-sided obstructive lesions; RSOL (right-sided obstructive lesions) and MTC (mixed type of CHD). All patients underwent fetal echocardiography, ultrasound evaluation, a magnetic resonance of the fetal brain, and genetic counseling. Results: The analysis of 63 fetuses shows statistically significant results in Doppler velocimetry among the different CHD groups. The RSOL group leads to higher umbilical artery (UA-PI) pressure indexes values, whereas the LSOL group correlates with significantly lower values of the middle cerebral artery (MCA-PI) compared to the other subgroups (p = 0.036), whereas the RSOL group shows a tendency to higher pulsatility indexes in the umbilical artery (UA-PI). A significant correlation has been found between a reduced head circumference (HC) and the presence of brain injury at MRI (p = 0.003). Conclusions: Congenital left- and right-sided cardiac obstructive lesions are responsible for fetal hemodynamic changes and brain growth impairment. The correct evaluation of the central nervous system (CNS) in fetuses affected by CHD could be essential as prenatal screening and the prediction of postnatal abnormalities.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Journal of Clinical ...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Journal of Clinical Medicine
    Article . 2022
    Data sources: DOAJ
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      Journal of Clinical Medicine
      Article . 2022
      Data sources: DOAJ
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  • Authors: Z L, LUR'E;
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  • Authors: H J, BOCHNIK;
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  • Authors: P, DURAND; C, ZUNIN;
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  • Authors: R, Walbaum; M F, Van de Velde-Staquet; J, Bahon-Le Capon; B, Boudiguet; +3 Authors
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  • Authors: I, Murano;
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  • Authors: W, DeMyer;

    Brain malformations have been classified on the basis of the types of errors which occur during embryologic development. The basis of the classification is the level of formative pathogenesis at which the error occurs. Development can be artificially regarded as consisting of cytogenesis, histogenesis, and organogenesis. Although the final stage of a malformation can be classified under one of these headings, the categories are not mutually exclusive. The classification is given in the form of a dendrogram which permits any further degree of specificity or subdivision desired.

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  • Authors: Jones, Sharon Marie;

    The purpose of this study was to document a normal range of measures observed in cranial transillumination obtained from testing neurologically intact full-term infants. Ranges, means, and standards deviations in millimeters of transilluminated light of five regions of the skull, i.e., anterior fontanel, frontal midline, left biparietal, right biparietal, and occipital midline regions, were determined. Additional variables, e.g. molding, age when tested, sex, birth weight, type of delivery, head circumference, and size of the anterior fontanel, were analyzed to ascertain if there was any relationship between these variables and the amount of light transilluminated. The study was conducted at the Latter-day Saints Hospital during a 3-week time period. Forty-seven infants were tested between the twenty -fourth and seventy-second hours of life. Parental informed consent was obtained prior to conducting the transillumination procedure. The data were analyzed through the University of Utah Computer Center utilizing a Univac computer. A breakdown program and P Pearson product-moment correlation coefficient were obtained. More light was observed in the anterior fontanel and frontal midline regions than the biparietal areas and more in the biparietal areas than the occipital areas. Generally, the amount of transilluminated light seemed to decrease from the anterior to posterior regions of the head when suture lines were open or adjacent. When the sagittal suture line was overriding there was an increase in the amount of transillumination observed in the frontal midline area. Total transilluminated light, i.e., the sum of the millimeter reading for the five skull areas, was also considered for each infant. The mean was 30.02 millimeters. Standard deviation was 5.77 millimeters. Thirty-one infants scored in this range. Fourteen infants scored in the second standard deviation. Two infants scored above the second standard deviation. These infants were presented. Increasing amounts of light were noted in infants tested from 24 to 37 hours of age, then the amount of transilluminated light showed a slight decline. This trend should be further investigated. Problems and concerns noted during the study as well a recommendations and implications for future research in this areas were discussed.

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  • Authors: H, Bitran; E, Weinhouse; M, Grief; H, Zirkin;
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