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34,618 research outcomes, page 1 of 3,462
  • publication . Other literature type . Article . 2005
    Open Access
    Authors:
    Carmelo Sgobio; Martine Ammassari-Teule; Claudia Bagni;
    Publisher: Proceedings of the National Academy of Sciences

    Fragile X syndrome, the most frequent form of hereditary mental retardation, is due to a mutation of the fragile X mental retardation 1 (FMR1) gene on the X chromosome. Like fragile X patients, FMR1-knockout (FMR1-KO) mice lack the normal fragile X mental retardation pr...

  • publication . Other literature type . Article . 2015
    Open Access
    Authors:
    Mayumi Muto; Masahiro Mori; Takaki Hiwasa; Masaki Takiguchi; Yasuo Iwadate; Akiyuki Uzawa; Tomohiko Uchida; Hiroki Masuda; Kazuo Sugimoto; Satoshi Kuwabara;
    Publisher: Elsevier BV

    article i nfo In the pathogenesis of multiple sclerosis (MS), B cell/antibody-related mechanisms haverecently received atten- tion. To investigate the role of autoantibody in MS, we performed SEREX which can identify autoantibody cyclopedically. We identified serum anti...

  • publication . Article . 2009
    Open Access
    Authors:
    Smith Desmond J; Obradovic Zoran; Chin Mark H; Xie Hongbo; An Li; Megalooikonomou Vasileios;
    Publisher: eScholarship, University of California
    Project: NSF | CAREER: Extracting Patter... (0237921), NSF | III-COR: Collaborative Re... (0705215), NIH | Large Scale Data Analysis... (1R01MH068066-01A1)

    <p>Abstract</p> <p>Background</p> <p>Gene expression signatures in the mammalian brain hold the key to understanding neural development and neurological disease. Researchers have previously used voxelation in combination with microarrays for acquisition of genome-wide a...

  • publication . Article . 2014
    Open Access
    Authors:
    Randy L. Gollub;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Mentoring in Addiction Tr... (1K24DA030443-01), NIH | SPATIOTEMPORAL FORWARD MO... (5P41RR014075-10), NIH | Training in Patient-Orien... (5K23DA032612-02)

    Neural substrates underlying the human-pet relationship are largely unknown. We examined fMRI brain activation patterns as mothers viewed images of their own child and dog and an unfamiliar child and dog. There was a common network of brain regions involved in emotion, ...

  • publication . Article . Other literature type . 2009
    Open Access
    Authors:
    Genevieve Konopka;
    Project: NIH | Identification and Charac... (2R37MH060233-06A1), NIH | Training Grant in Neurobe... (2T32MH073526-06), NIH | Identification of targets... (5R21MH075028-02), NIH | MENTAL RETARDATION (5T32HD007032-20)

    The transcription factor FOXP2 is the only gene so far to have been implicated in human speech, yet it differs very little from the chimpanzee equivalent. New experiments reveal differences between the activation of downstream transcriptional targets of FOXP2 in humans ...

  • publication . Article . 2016
    Open Access English
    Authors:
    Liddle, Elizabeth B.; Price, Darren; Palaniyappan, Lena; Brookes, Matthew J.; Robson, Siân E.; Hall, Emma L.; Morris, Peter G.; Liddle, Peter F.;
    Publisher: Wiley

    Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, exaggerating the sign...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Nicola Toschi; Riccardo Barbieri; Stefano Orsolini;
    Project: EC | LINK (692023)

    Task- and stimulus-based neuroimaging studies have begun to unveil the central autonomic network which modulates autonomic nervous system activity. In the present study, we aimed to evaluate the central autonomic network without the bias constituted by the use of a task...

  • publication . Other literature type . Article . 2010
    Open Access English
    Authors:
    Uri Hasson; G.J. Stephens;
    Publisher: National Academy of Sciences

    Verbal communication is a joint activity; however, speech production and comprehension have primarily been analyzed as independent processes within the boundaries of individual brains. Here, we applied fMRI to record brain activity from both speakers and listeners durin...

  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Nicholas J. Schork;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Blood Biomarkers for Psyc... (5I01CX000139-05), NIH | Developing Blood Tests fo... (1DP2OD007363-01)

    Anxiety disorders are prevalent and disabling yet understudied from a genetic standpoint, compared with other major psychiatric disorders such as bipolar disorder and schizophrenia. The fact that they are more common, diverse and perceived as embedded in normal life may...

  • publication . Article . 2017
    Open Access English
    Authors:
    Vishal Patel; Leith Hathout;
    Publisher: BMC

    Abstract Background The heterogeneity of response to treatment in patients with glioblastoma multiforme suggests that the optimal therapeutic approach incorporates an individualized assessment of expected lesion progression. In this work, we develop a novel computationa...

34,618 research outcomes, page 1 of 3,462