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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Fahrenfort, Johannes Jacobus; Grubert, Anna; Olivers, Christian N. L.; Eimer, Martin;

    Abstract The primary electrophysiological marker of feature-based selection is the N2pc, a lateralized posterior negativity emerging around 180-200 ms. As it relies on hemispheric differences, its ability to discriminate the locus of focal attention is severely limited. Here we demonstrate that multivariate analyses of raw EEG data provide a much more fine-grained spatial profile of feature-based target selection. When training a pattern classifier to determine target position from EEG, we were able to decode target positions on the vertical midline, which cannot be achieved using standard N2pc methodology. Next, we used a forward encoding model to construct a channel tuning function that describes the continuous relationship between target position and multivariate EEG in an eight-position display. This model can spatially discriminate individual target positions in these displays and is fully invertible, enabling us to construct hypothetical topographic activation maps for target positions that were never used. When tested against the real pattern of neural activity obtained from a different group of subjects, the constructed maps from the forward model turned out statistically indistinguishable, thus providing independent validation of our model. Our findings demonstrate the power of multivariate EEG analysis to track feature-based target selection with high spatial and temporal precision. Significance Statement Feature-based attentional selection enables observers to find objects in their visual field. The spatiotemporal profile of this process is difficult to assess with standard electrophysiological methods, which rely on activity differences between cerebral hemispheres. We demonstrate that multivariate analyses of EEG data can track target selection across the visual field with high temporal and spatial resolution. Using a forward model, we were able to capture the continuous relationship between target position and EEG measurements, allowing us to reconstruct the distribution of cortical activity for target locations that were never shown during the experiment. Our findings demonstrate the existence of a temporally and spatially precise EEG signal that can be used to study the neural basis of feature-based attentional selection.

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    Scientific Reports
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    Authors: Flavie Torrecillos; Emma Falato; Alek Pogosyan; Tim West; +2 Authors

    Brain oscillations involve rhythmic fluctuations of neuronal excitability and may play a crucial role in neural communication. The human corticomuscular system is characterized by beta activity and is readily probed by transcranial magnetic stimulation (TMS). TMS inputs arriving at the excitable phase of beta oscillations in the motor cortex are known to lead to muscle responses of greater amplitude. Here we explore two other possible manifestations of rhythmic excitability in the beta band; windows of reduced response variability and shortened latency. We delivered single-pulse TMS to the motor cortex of healthy human volunteers (10 females and 7 males) during electroencephalography recordings made at rest. TMS delivered at a particular phase of the beta oscillation benefited from not only stronger, but also less variable and more rapid transmission, as evidenced by the greater amplitude, lower coefficient of variation, and shorter latency of motor evoked potentials. Thus, inputs aligned to the optimal phase of the beta EEG in the motor cortex enjoy transmission amplitude gain, but may also benefit from less variability and shortened latencies at subsequent synapses. Neuronal phase may therefore impact corticospinal communication.SIGNIFICANCE STATEMENTBrain oscillations involve rhythmic fluctuations of neuronal excitability. Therefore, motor responses to transcranial magnetic stimulation are larger when a cortical input arrives at a particular phase of the beta activity in the motor cortex. Here, we demonstrate that inputs to corticospinal neurons which coincide with windows of higher excitability also benefit from more rapid and less variable corticospinal transmission. This shortening of latency and increased reproducibility may confer additional advantage to inputs at specific phases. Moreover, these benefits are conserved despite appreciable corticospinal conduction delays.

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    Journal of Neuroscience
    Article . 2019 . Peer-reviewed
    License: CC BY NC SA
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    UCL Discovery
    Article . 2020
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    Journal of Neuroscience
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      Journal of Neuroscience
      Article . 2019 . Peer-reviewed
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      UCL Discovery
      Article . 2020
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      Journal of Neuroscience
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    Authors: Keable, Abby; Fenna, Kate; Yuen, Ho Ming; Johnston, David A.; +9 Authors

    Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy (CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain. As CAA is associated with Alzheimer's disease and with intracerebral haemorrhage, the present study determines the unique sequence of changes that occur as Aβ accumulates in artery walls. Paraffin sections of post-mortem human occipital cortex were immunostained for collagen IV, fibronectin, nidogen 2, Aβ and smooth muscle actin and the immunostaining was analysed using Image J and confocal microscopy. Results showed that nidogen 2 (entactin) increases with age and decreases in CAA. Confocal microscopy revealed stages in the progression of CAA: Aβ initially deposits in basement membranes in the tunica media, replaces first the smooth muscle cells and then the connective tissue elements to leave artery walls completely or focally replaced by Aβ. The pattern of development of CAA in the human brain suggests expansion of Aβ from the basement membranes to progressively replace all tissue elements in the artery wall. Establishing this full picture of the development of CAA is pivotal in understanding the clinical presentation of CAA and for developing therapies to prevent accumulation of Aβ in artery walls. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. Highlights • Lymphatic drainage of the brain is along basement membranes in the walls of arteries. • Perivascular lymphatic drainage fails with age and arteriosclerosis. • Aβ deposits in the perivascular drainage pathways of leptomeningeal arteries as CAA. • As CAA progresses, Aβ replaces all elements of the ageing artery wall. • Facilitation of perivascular drainage may prevent CAA and delay Alzheimer's disease.

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    Authors: Maurin, David;

    Ce document est constitué de deux parties et de deux annexes . Dans le chap. 1, je parle de la composante nucléaire du rayonnement cosmique galactique, des enjeux astrophysiques et ceux reliés à la matière noire. Le chap. 2 est consacré à l'étude des émissions gamma dues à l'annihilation de matière noire. Le fil conducteur est la recherche indirecte de matière noire, qui passe par la maîtrise du signal et des fonds astrophysiques. Chaque partie propose une introduction du sujet, un état des lieux, une compilation des résultats obtenus et quelques perspectives et directions de recherches à développer pour les années à venir. La conclusion générale revient sur le lien et la complémentarité des particules chargés et neutres et l'articulation de ces deux messagers pour de futures études hors de la Galaxie. L'annexe A présente quelques outils développés utilisés pour ces études et qui ont été rendus publics. L'annexe B, un peu plus personnelle, revient sur mon parcours, mon CV et le rôle que j'ai pu avoir dans l'encadrement d'étudiants de master et de thèse et dans l'animation scientifique. This document consists of two parts and two annexes. In chapter 1, I present the nuclear component of the galactic cosmic radiation, and discuss astrophysical and dark matter issues. Chapter 2 is devoted to the study of gamma-ray emissions from the annihilation of dark matter. The common thread is the indirect search for dark matter, which relies on the signal and astrophysical background modelling. Each part provides an introduction to the subject, an overview, a compilation of results and some perspectives and research directions to develop for the coming years. To conclude, I underline the link and complementarity between charged and neutral particle studies for galactic and extragalactic objects. Appendix A presents some public tools developed for these studies. Appendix B is more personal, and provides my CV and describes my role supervising master and PhD students.

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    Authors: Boer, Daniel; Diehl, Markus; Milner, Richard; Venugopalan, Raju; +196 Authors

    This report is based on a ten-week program on "Gluons and the quark sea at high-energies", which took place at the Institute for Nuclear Theory in Seattle in Fall 2010. The principal aim of the program was to develop and sharpen the science case for an Electron-Ion Collider (EIC), a facility that will be able to collide electrons and positrons with polarized protons and with light to heavy nuclei at high energies, offering unprecedented possibilities for in-depth studies of quantum chromodynamics. This report is organized around four major themes: i) the spin and flavor structure of the proton, ii) three-dimensional structure of nucleons and nuclei in momentum and configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and the search for physics beyond the Standard Model. Beginning with an executive summary, the report contains tables of key measurements, chapter overviews for each of the major scientific themes, and detailed individual contributions on various aspects of the scientific opportunities presented by an EIC. Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science case for an Electron-Ion Collider, September 13 to November 19, 2010, Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed version

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    Other literature type . Preprint . 2011
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    Authors: J M, Rusted; S L, Evans; S L, King; N, Dowell; +2 Authors

    The APOE e4 allele, which confers an increased risk of developing dementia in older adulthood, has been associated with enhanced cognitive performance in younger adults. An objective of the current study was to compare task-related behavioural and neural signatures for e4 carriers (e4+) and non-e4 carriers (e4-) to help elucidate potential mechanisms behind such cognitive differences. On two measures of attention, we recorded clear behavioural advantages in young adult e4+ relative to e4-, suggesting that e4+ performed these tasks with a wider field of attention. Behavioural advantages were associated with increased task-related brain activations detected by fMRI (BOLD). In addition, behavioural measures correlated with structural measures derived from a former DTI analysis of white matter integrity in our cohort. These data provide clear support for an antagonistic pleiotropy hypothesis - that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age. The data implicate differences in both structural and functional signatures as complementary mediators of the behavioural advantage.

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    NeuroImage
    Article . 2013 . Peer-reviewed
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    NeuroImage
    Article . 2012
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      NeuroImage
      Article . 2012
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    Authors: Catherine McCaig; Paris Ataliotis; Anan Shtaya; Ayan S Omar; +8 Authors

    Nitrones (e.g. α-phenyl-N-tert-butyl nitrone; PBN) are cerebroprotective in experimental stroke. Free radical trapping is their proposed mechanism. As PBN has low radical trapping potency, we tested Sgk1 induction as another possible mechanism. PBN was injected (100 mg/kg, i.p.) into adult male rats and mice. Sgk1 was quantified in cerebral tissue by microarray, quantitative RT-PCR and western analyses. Sgk1+/+ and Sgk1−/− mice were randomized to receive PBN or saline immediately following transient (60 min) occlusion of the middle cerebral artery. Neurological deficit was measured at 24 h and 48 h and infarct volume at 48 h post-occlusion. Following systemic PBN administration, rapid induction of Sgk1 was detected by microarray (at 4 h) and confirmed by RT-PCR and phosphorylation of the Sgk1-specific substrate NDRG1 (at 6 h). PBN-treated Sgk1+/+ mice had lower neurological deficit ( p < 0.01) and infarct volume ( p < 0.01) than saline-treated Sgk1+/+ mice. PBN-treated Sgk1−/− mice did not differ from saline-treated Sgk1−/− mice. Saline-treated Sgk1−/− and Sgk1+/+ mice did not differ. Brain Sgk3:Sgk1 mRNA ratio was 1.0:10.6 in Sgk1+/+ mice. Sgk3 was not augmented in Sgk1−/− mice. We conclude that acute systemic treatment with PBN induces Sgk1 in brain tissue. Sgk1 may play a part in PBN-dependent actions in acute brain ischemia.

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    Journal of Cerebral Blood Flow & Metabolism
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    Journal of Cerebral Blood Flow & Metabolism
    Article . 2017 . Peer-reviewed
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      Journal of Cerebral Blood Flow & Metabolism
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    Authors: Barate, R.; Buskulic, D.; Decamp, D.; Ghez, Philippe; +197 Authors

    During 1997 the ALEPH experiment at LEP gathered $57 \pb$ of data at centre-of-mass energies near $183 ~\G$. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction $\ee\r\H\Z$. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: $\mH > 87.9 \Gcs$ at 95\% confidence level. During 1997 the ALEPH experiment at LEP gathered 57 pb −1 of data at centre-of-mass energies near 183 GeV . These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e + e − →HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m H >87.9 GeV /c 2 at 95% confidence level. During 1997 the ALEPH experiment at LEP gathered 57 pb −1 of data at centre-of-mass energies near 183 GeV. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e + e − →HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m H >87.9 GeV /c 2 at 95% confidence level. During 1997 the ALEPH experiment at LEP gathered 57pb^-1 of data at centre-of- mass energies near 183 GeV. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e+e- -> HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m_H > 87.9GeV/c^2 at 95% confidence level.

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    Other literature type . 1998
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    Authors: Hatton, Sean N; Huynh, Khoa H; Bonilha, Leonardo; Abela, Eugenio; +70 Authors

    AbstractThe epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.

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    Authors: Patience A. Cowie; C. H. Scholz; Gerald P. Roberts; J. Faure Walker; +1 Authors

    Viscous flow at depth contributes to elastic strain accumulation along seismogenic faults during both post-seismic and inter-seismic phases of the earthquake cycle. Evaluating the importance of this contribution is hampered by uncertainties regarding (i) the extent to which viscous deformation occurs in shear zones or by distributed flow within the crust and/or upper mantle, and (ii) the value of the exponent, n, in the flow law that relates strain rate to applied stress. Geodetic data, rock deformation experiments, and field observations of exhumed (inactive) faults provide strong evidence for non-linear viscous flow but may not fully capture the long term, in situ behaviour of active fault zones. Here we demonstrate that strain rates derived from Holocene offsets on seismogenic normal faults in the actively uplifting and extending central and southern Italian Apennines may be used to address this issue. The measured strain rates, averaged over a time scale of 104 years, exhibit a well-defined power-law dependence on topographic elevation with a power-law exponent ≈ 3.0 (2.7 - 3.4 at 95% CI; 2.3 - 4.0 at 99% CI). Contemporary seismicity indicates that the upper crust in this area is at the threshold for frictional failure within an extensional stress field and therefore differential stress is directly proportional to elevation. Our data thus imply a relationship between strain rate and stress that is consistent with non-linear viscous flow, with n ≈ 3, but because the measurements are derived from slip along major crustal faults they do not represent deformation of a continuum. We know that, down-dip of the seismogenic part of active faults, cataclasis, hydrous alteration, and shear heating all contribute to grain size reduction and material weakening. These processes initiate localisation at the frictional-viscous transition and the development of mylonitic shear zones within the viscous regime. Furthermore, in quartzo-feldspathic crust, mylonites form a fabric of mineral segregated layers parallel to shear with their strength controlled by the weakest phase: quartz. Using a published flow law for wet quartz calibrated for mylonitic rocks to fit the strain rates across individual fault zones (~5 km wide), we estimate a lower bound on the temperature of the deforming material using our data. This temperature is reached at or just below the base of the seismogenic zone, as constrained by regional surface heat flow data and the depth distribution of crustal seismicity. We conclude that it is the rate of viscous flow in quartz-rich mylonitic shear zones, not distributed flow within the lower crust and/or upper mantle, which modulates the Holocene slip rates on the up-dip seismogenic part of the faults in this area. Our observations support the idea that the irregular, stick-slip movement of brittle faults, and hence earthquake recurrence, are ultimately modulated by down-dip viscous flow over multiple earthquake cycles. International audience

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    Nature Geoscience
    Article . 2013 . Peer-reviewed
    License: Springer TDM
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    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2013
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    Authors: Fahrenfort, Johannes Jacobus; Grubert, Anna; Olivers, Christian N. L.; Eimer, Martin;

    Abstract The primary electrophysiological marker of feature-based selection is the N2pc, a lateralized posterior negativity emerging around 180-200 ms. As it relies on hemispheric differences, its ability to discriminate the locus of focal attention is severely limited. Here we demonstrate that multivariate analyses of raw EEG data provide a much more fine-grained spatial profile of feature-based target selection. When training a pattern classifier to determine target position from EEG, we were able to decode target positions on the vertical midline, which cannot be achieved using standard N2pc methodology. Next, we used a forward encoding model to construct a channel tuning function that describes the continuous relationship between target position and multivariate EEG in an eight-position display. This model can spatially discriminate individual target positions in these displays and is fully invertible, enabling us to construct hypothetical topographic activation maps for target positions that were never used. When tested against the real pattern of neural activity obtained from a different group of subjects, the constructed maps from the forward model turned out statistically indistinguishable, thus providing independent validation of our model. Our findings demonstrate the power of multivariate EEG analysis to track feature-based target selection with high spatial and temporal precision. Significance Statement Feature-based attentional selection enables observers to find objects in their visual field. The spatiotemporal profile of this process is difficult to assess with standard electrophysiological methods, which rely on activity differences between cerebral hemispheres. We demonstrate that multivariate analyses of EEG data can track target selection across the visual field with high temporal and spatial resolution. Using a forward model, we were able to capture the continuous relationship between target position and EEG measurements, allowing us to reconstruct the distribution of cortical activity for target locations that were never shown during the experiment. Our findings demonstrate the existence of a temporally and spatially precise EEG signal that can be used to study the neural basis of feature-based attentional selection.

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    Scientific Reports
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    Authors: Flavie Torrecillos; Emma Falato; Alek Pogosyan; Tim West; +2 Authors

    Brain oscillations involve rhythmic fluctuations of neuronal excitability and may play a crucial role in neural communication. The human corticomuscular system is characterized by beta activity and is readily probed by transcranial magnetic stimulation (TMS). TMS inputs arriving at the excitable phase of beta oscillations in the motor cortex are known to lead to muscle responses of greater amplitude. Here we explore two other possible manifestations of rhythmic excitability in the beta band; windows of reduced response variability and shortened latency. We delivered single-pulse TMS to the motor cortex of healthy human volunteers (10 females and 7 males) during electroencephalography recordings made at rest. TMS delivered at a particular phase of the beta oscillation benefited from not only stronger, but also less variable and more rapid transmission, as evidenced by the greater amplitude, lower coefficient of variation, and shorter latency of motor evoked potentials. Thus, inputs aligned to the optimal phase of the beta EEG in the motor cortex enjoy transmission amplitude gain, but may also benefit from less variability and shortened latencies at subsequent synapses. Neuronal phase may therefore impact corticospinal communication.SIGNIFICANCE STATEMENTBrain oscillations involve rhythmic fluctuations of neuronal excitability. Therefore, motor responses to transcranial magnetic stimulation are larger when a cortical input arrives at a particular phase of the beta activity in the motor cortex. Here, we demonstrate that inputs to corticospinal neurons which coincide with windows of higher excitability also benefit from more rapid and less variable corticospinal transmission. This shortening of latency and increased reproducibility may confer additional advantage to inputs at specific phases. Moreover, these benefits are conserved despite appreciable corticospinal conduction delays.

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    Journal of Neuroscience
    Article . 2019 . Peer-reviewed
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    UCL Discovery
    Article . 2020
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      Journal of Neuroscience
      Article . 2019 . Peer-reviewed
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    Authors: Keable, Abby; Fenna, Kate; Yuen, Ho Ming; Johnston, David A.; +9 Authors

    Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy (CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain. As CAA is associated with Alzheimer's disease and with intracerebral haemorrhage, the present study determines the unique sequence of changes that occur as Aβ accumulates in artery walls. Paraffin sections of post-mortem human occipital cortex were immunostained for collagen IV, fibronectin, nidogen 2, Aβ and smooth muscle actin and the immunostaining was analysed using Image J and confocal microscopy. Results showed that nidogen 2 (entactin) increases with age and decreases in CAA. Confocal microscopy revealed stages in the progression of CAA: Aβ initially deposits in basement membranes in the tunica media, replaces first the smooth muscle cells and then the connective tissue elements to leave artery walls completely or focally replaced by Aβ. The pattern of development of CAA in the human brain suggests expansion of Aβ from the basement membranes to progressively replace all tissue elements in the artery wall. Establishing this full picture of the development of CAA is pivotal in understanding the clinical presentation of CAA and for developing therapies to prevent accumulation of Aβ in artery walls. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. Highlights • Lymphatic drainage of the brain is along basement membranes in the walls of arteries. • Perivascular lymphatic drainage fails with age and arteriosclerosis. • Aβ deposits in the perivascular drainage pathways of leptomeningeal arteries as CAA. • As CAA progresses, Aβ replaces all elements of the ageing artery wall. • Facilitation of perivascular drainage may prevent CAA and delay Alzheimer's disease.

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    Authors: Maurin, David;

    Ce document est constitué de deux parties et de deux annexes . Dans le chap. 1, je parle de la composante nucléaire du rayonnement cosmique galactique, des enjeux astrophysiques et ceux reliés à la matière noire. Le chap. 2 est consacré à l'étude des émissions gamma dues à l'annihilation de matière noire. Le fil conducteur est la recherche indirecte de matière noire, qui passe par la maîtrise du signal et des fonds astrophysiques. Chaque partie propose une introduction du sujet, un état des lieux, une compilation des résultats obtenus et quelques perspectives et directions de recherches à développer pour les années à venir. La conclusion générale revient sur le lien et la complémentarité des particules chargés et neutres et l'articulation de ces deux messagers pour de futures études hors de la Galaxie. L'annexe A présente quelques outils développés utilisés pour ces études et qui ont été rendus publics. L'annexe B, un peu plus personnelle, revient sur mon parcours, mon CV et le rôle que j'ai pu avoir dans l'encadrement d'étudiants de master et de thèse et dans l'animation scientifique. This document consists of two parts and two annexes. In chapter 1, I present the nuclear component of the galactic cosmic radiation, and discuss astrophysical and dark matter issues. Chapter 2 is devoted to the study of gamma-ray emissions from the annihilation of dark matter. The common thread is the indirect search for dark matter, which relies on the signal and astrophysical background modelling. Each part provides an introduction to the subject, an overview, a compilation of results and some perspectives and research directions to develop for the coming years. To conclude, I underline the link and complementarity between charged and neutral particle studies for galactic and extragalactic objects. Appendix A presents some public tools developed for these studies. Appendix B is more personal, and provides my CV and describes my role supervising master and PhD students.

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    Authors: Boer, Daniel; Diehl, Markus; Milner, Richard; Venugopalan, Raju; +196 Authors

    This report is based on a ten-week program on "Gluons and the quark sea at high-energies", which took place at the Institute for Nuclear Theory in Seattle in Fall 2010. The principal aim of the program was to develop and sharpen the science case for an Electron-Ion Collider (EIC), a facility that will be able to collide electrons and positrons with polarized protons and with light to heavy nuclei at high energies, offering unprecedented possibilities for in-depth studies of quantum chromodynamics. This report is organized around four major themes: i) the spin and flavor structure of the proton, ii) three-dimensional structure of nucleons and nuclei in momentum and configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and the search for physics beyond the Standard Model. Beginning with an executive summary, the report contains tables of key measurements, chapter overviews for each of the major scientific themes, and detailed individual contributions on various aspects of the scientific opportunities presented by an EIC. Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science case for an Electron-Ion Collider, September 13 to November 19, 2010, Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed version

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    Authors: J M, Rusted; S L, Evans; S L, King; N, Dowell; +2 Authors

    The APOE e4 allele, which confers an increased risk of developing dementia in older adulthood, has been associated with enhanced cognitive performance in younger adults. An objective of the current study was to compare task-related behavioural and neural signatures for e4 carriers (e4+) and non-e4 carriers (e4-) to help elucidate potential mechanisms behind such cognitive differences. On two measures of attention, we recorded clear behavioural advantages in young adult e4+ relative to e4-, suggesting that e4+ performed these tasks with a wider field of attention. Behavioural advantages were associated with increased task-related brain activations detected by fMRI (BOLD). In addition, behavioural measures correlated with structural measures derived from a former DTI analysis of white matter integrity in our cohort. These data provide clear support for an antagonistic pleiotropy hypothesis - that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age. The data implicate differences in both structural and functional signatures as complementary mediators of the behavioural advantage.

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    NeuroImage
    Article . 2013 . Peer-reviewed
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    NeuroImage
    Article . 2012
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    Authors: Catherine McCaig; Paris Ataliotis; Anan Shtaya; Ayan S Omar; +8 Authors

    Nitrones (e.g. α-phenyl-N-tert-butyl nitrone; PBN) are cerebroprotective in experimental stroke. Free radical trapping is their proposed mechanism. As PBN has low radical trapping potency, we tested Sgk1 induction as another possible mechanism. PBN was injected (100 mg/kg, i.p.) into adult male rats and mice. Sgk1 was quantified in cerebral tissue by microarray, quantitative RT-PCR and western analyses. Sgk1+/+ and Sgk1−/− mice were randomized to receive PBN or saline immediately following transient (60 min) occlusion of the middle cerebral artery. Neurological deficit was measured at 24 h and 48 h and infarct volume at 48 h post-occlusion. Following systemic PBN administration, rapid induction of Sgk1 was detected by microarray (at 4 h) and confirmed by RT-PCR and phosphorylation of the Sgk1-specific substrate NDRG1 (at 6 h). PBN-treated Sgk1+/+ mice had lower neurological deficit ( p < 0.01) and infarct volume ( p < 0.01) than saline-treated Sgk1+/+ mice. PBN-treated Sgk1−/− mice did not differ from saline-treated Sgk1−/− mice. Saline-treated Sgk1−/− and Sgk1+/+ mice did not differ. Brain Sgk3:Sgk1 mRNA ratio was 1.0:10.6 in Sgk1+/+ mice. Sgk3 was not augmented in Sgk1−/− mice. We conclude that acute systemic treatment with PBN induces Sgk1 in brain tissue. Sgk1 may play a part in PBN-dependent actions in acute brain ischemia.

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    Journal of Cerebral Blood Flow & Metabolism
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    Journal of Cerebral Blood Flow & Metabolism
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    Authors: Barate, R.; Buskulic, D.; Decamp, D.; Ghez, Philippe; +197 Authors

    During 1997 the ALEPH experiment at LEP gathered $57 \pb$ of data at centre-of-mass energies near $183 ~\G$. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction $\ee\r\H\Z$. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: $\mH > 87.9 \Gcs$ at 95\% confidence level. During 1997 the ALEPH experiment at LEP gathered 57 pb −1 of data at centre-of-mass energies near 183 GeV . These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e + e − →HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m H >87.9 GeV /c 2 at 95% confidence level. During 1997 the ALEPH experiment at LEP gathered 57 pb −1 of data at centre-of-mass energies near 183 GeV. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e + e − →HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m H >87.9 GeV /c 2 at 95% confidence level. During 1997 the ALEPH experiment at LEP gathered 57pb^-1 of data at centre-of- mass energies near 183 GeV. These data are used to look for possible signals from the production of the Standard Model Higgs boson in the reaction e+e- -> HZ. No evidence of a signal is found in the data; seven events are selected, in agreement with the expectation of 7.2 events from background processes. This observation results in an improved lower limit on the mass of the Higgs boson: m_H > 87.9GeV/c^2 at 95% confidence level.

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    CERN Document Server
    Other literature type . 1998
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    Authors: Hatton, Sean N; Huynh, Khoa H; Bonilha, Leonardo; Abela, Eugenio; +70 Authors

    AbstractThe epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.

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    Authors: Patience A. Cowie; C. H. Scholz; Gerald P. Roberts; J. Faure Walker; +1 Authors

    Viscous flow at depth contributes to elastic strain accumulation along seismogenic faults during both post-seismic and inter-seismic phases of the earthquake cycle. Evaluating the importance of this contribution is hampered by uncertainties regarding (i) the extent to which viscous deformation occurs in shear zones or by distributed flow within the crust and/or upper mantle, and (ii) the value of the exponent, n, in the flow law that relates strain rate to applied stress. Geodetic data, rock deformation experiments, and field observations of exhumed (inactive) faults provide strong evidence for non-linear viscous flow but may not fully capture the long term, in situ behaviour of active fault zones. Here we demonstrate that strain rates derived from Holocene offsets on seismogenic normal faults in the actively uplifting and extending central and southern Italian Apennines may be used to address this issue. The measured strain rates, averaged over a time scale of 104 years, exhibit a well-defined power-law dependence on topographic elevation with a power-law exponent ≈ 3.0 (2.7 - 3.4 at 95% CI; 2.3 - 4.0 at 99% CI). Contemporary seismicity indicates that the upper crust in this area is at the threshold for frictional failure within an extensional stress field and therefore differential stress is directly proportional to elevation. Our data thus imply a relationship between strain rate and stress that is consistent with non-linear viscous flow, with n ≈ 3, but because the measurements are derived from slip along major crustal faults they do not represent deformation of a continuum. We know that, down-dip of the seismogenic part of active faults, cataclasis, hydrous alteration, and shear heating all contribute to grain size reduction and material weakening. These processes initiate localisation at the frictional-viscous transition and the development of mylonitic shear zones within the viscous regime. Furthermore, in quartzo-feldspathic crust, mylonites form a fabric of mineral segregated layers parallel to shear with their strength controlled by the weakest phase: quartz. Using a published flow law for wet quartz calibrated for mylonitic rocks to fit the strain rates across individual fault zones (~5 km wide), we estimate a lower bound on the temperature of the deforming material using our data. This temperature is reached at or just below the base of the seismogenic zone, as constrained by regional surface heat flow data and the depth distribution of crustal seismicity. We conclude that it is the rate of viscous flow in quartz-rich mylonitic shear zones, not distributed flow within the lower crust and/or upper mantle, which modulates the Holocene slip rates on the up-dip seismogenic part of the faults in this area. Our observations support the idea that the irregular, stick-slip movement of brittle faults, and hence earthquake recurrence, are ultimately modulated by down-dip viscous flow over multiple earthquake cycles. International audience

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    Nature Geoscience
    Article . 2013 . Peer-reviewed
    License: Springer TDM
    Data sources: Crossref
    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2013
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