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description Publicationkeyboard_double_arrow_right Article 2015 FrancePublisher:Elsevier BV Funded by:NSERCNSERCBureau Du Colombier, Sarah; Jacobs, Louis; Gesset, Charline; Elie, Pierre; Lambert, Patrick;[Departement_IRSTEA]Eaux [TR1_IRSTEA]QUASARE; International audience; In the context of the severe decrease in temperate eel abundance, understanding and control of eel maturation has strong interest for scientific and commercial purposes. Possible use of ultrasonography for improvement of sex determination and maturation monitoring in silver eel was investigated. Gonads of 96 Anguilla anguilla silver eels were observed using portable equipment associated to a 6-15MHz probe, and sex determination was tried before artificial induction of maturation. To estimate gonad mass and monitor individual gonadosomatic index (GSI) in females, cross-sectional images were captured at different times of maturation and gonad length was measured at scanning. Two methods were tried for ovary mass estimation using ultrasonography: one based on a linear model and another on calculating ovary volume from a representation of gonad shape. Ultrasonography resulted in 100% success in sex determination. Ovary mass estimated by ultrasonography was strongly correlated to true ovary mass (R2=0.97). The use of a linear model for gonad mass and then GSI estimation seemed more appropriate than the use of a representation of gonad shape. Evolution of GSI estimates during maturation supports possible detection of early inter-individual differences in maturation using ultrasonography in female silver eels. This non-invasive tool can then obviously be exploited to improve sex determination in silver eels caught in the wild and to monitor maturation at the individual level. Ultrasonography thus has great potential for use in eel both for conservation and aquaculture. To our knowledge, this is the first report on the use of ultrasonography on eels or any anguillid species.
Fisheries Research arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fishres.2014.10.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Fisheries Research arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fishres.2014.10.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2012 France EnglishPublisher:HAL CCSD Funded by:NSERCNSERCHarrap, Rob; DANIEL, Sylvie; Power, Michael; Pearce, Joshua M.; Hedley, Nicholas;International audience; Research networks foster creativity and break down institutional barriers, but introduce new geographic barriers to communication and collaboration. In designing mobile educational games, our distributed team took advantage of diverse talent pools and differing perspectives to drive forward a core vision of our overarching design targets. Our strategies included intense design workshops, use of online meeting rooms, paper and software prototyping as group activities, and dissemination of prototypes to other teams for refinement and repurposing. Our group showed strong activity at the university-centered nodes with periods of highly effective dissemination between these nodes and to outside groups; we used workshop invitations to gather new ideas and perspectives , to refine the vision, to forge inter-project links, and to stay current on what was happening in other networks. Several important aspects of our final deliverables came from loosely associated network members who engaged via collaborative design exercises in workshops, emphasizing the need to bring the network together and the importance of outside influences as ideas evolve. Our final deliverables demonstrate how our network both maintained a consistent vision and incorporated new ideas in the design of mobile augmented reality games, how our network experienced a new open approach of knowledge and technology sharing towards the sustainability of our research outcomes.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______177::300d0052834ff5f6b25357d8c9de3dcd&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2016Publisher:Cold Spring Harbor Laboratory Funded by:NSERC, CIHR, NIH | Neuroinformatics for gene... +2 projectsNSERC ,CIHR ,NIH| Neuroinformatics for gene expression: networks, function and meta-analysis ,NIH| Integrative Meta-analysis of Microarray Data ,NIH| Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major DepressionB. Ogan Mancarci; Lilah Toker; Shreejoy J. Tripathy; Brenna Li; Brad R. Rocco; Etienne Sibille; Paul Pavlidis;Establishing the molecular diversity of cell types is crucial for the study of the nervous system. We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes from 36 major cell types from across the mammalian brain using rigorously curated published data from pooled cell type microarray and single-cell RNA-sequencing (RNA-seq) studies. We used these data to identify cell type-specific marker genes, discovering a substantial number of novel markers, many of which we validated using computational and experimental approaches. We further demonstrate that summarized expression of marker gene sets (MGSs) in bulk tissue data can be used to estimate the relative cell type abundance across samples. To facilitate use of this expanding resource, we provide a user-friendly web interface at www.neuroexpresso.org. Visual Abstract
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5707795Data sources: PubMed CentralbioRxivPreprint . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/089219&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 122 citations 122 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5707795Data sources: PubMed CentralbioRxivPreprint . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/089219&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2020Publisher:Cold Spring Harbor Laboratory Funded by:NSERCNSERCAuthors: Grecias, Lucie; Hebert, Francois Olivier; Alves, Verônica Angelica; Barber, Iain; +1 AuthorsGrecias, Lucie; Hebert, Francois Olivier; Alves, Verônica Angelica; Barber, Iain; Aubin-Horth, Nadia;ABSTRACTMany parasites with complex life cycles modify their intermediate hosts’ behaviour, presumably to increase transmission to their final host. The threespine stickleback (Gasterosteus aculeatus) is an intermediate host in the cestodeSchistocephalus soliduslife cycle, which ends in an avian host, and shows increased risky behaviours when infected. We studied brain gene expression profiles of sticklebacks infected withS.solidusto determine the proximal causes of these behavioural alterations. We show that infected fish have altered expression levels in genes involved in the inositol pathway. We thus tested the functional implication of this pathway and successfully rescued normal behaviours in infected sticklebacks using lithium exposure. We also show that exposed but uninfected fish have a distinct gene expression profile from both infected fish and control individuals, allowing us to separate gene activity related to parasite exposure from consequences of a successful infection. Finally, we find that Selective Serotonin Reuptake Inhibitor (SSRI)-treated sticklebacks and infected fish do not have similarly altered gene expression, despite their comparable behaviours, suggesting that the serotonin pathway is probably not the main driver of phenotypic changes in infected sticklebacks. Taken together, our results allow us to predict that ifS.solidusdirectly manipulates its host, it could target the inositol pathway.
bioRxiv arrow_drop_down bioRxivPreprint . 2020Proceedings of the Royal Society B Biological SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.08.084764&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2020Proceedings of the Royal Society B Biological SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.08.084764&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Oxford University Press (OUP) Funded by:NSERCNSERCAuthors: Jithine Jayakumar Rajeswari; Azadeh Hatef; Suraj Unniappan;Jithine Jayakumar Rajeswari; Azadeh Hatef; Suraj Unniappan;pmid: 32542346
Nucleobindin (Nucb)-1 and Nucb2 are DNA and Ca2+ binding proteins with multiple functions in vertebrates. Prohormone convertase-mediated processing of Nucb2 results in the production of biologically active nesfatin-1. Nesfatin-1 is involved in the regulation of reproduction in many vertebrates, including fish. Our lab originally reported a nesfatin-1-like peptide (Nlp) encoded in Nucb1 that exhibits nesfatin-1-like metabolic effects. We hypothesized that Nlp has a suppressive role in the reproductive physiology of fish. In this research, whether Nlp regulates reproductive hormones and oocyte maturation in fish were determined. Single intraperitoneal (IP) injection of goldfish Nlp (50 ng/g body weight) suppressed salmon and chicken gonadotropin-releasing hormone (sgnrh and cgnrh2), gonadotropin-inhibiting hormone (gnih) and its receptor (gnihr), and kisspeptin and brain aromatase mRNA expression in the hypothalamus of both male and female goldfish. In the pituitary, Nlp decreased mRNAs encoding lhb, fshb and kisspeptin and its receptor, while a significant increase in gnih and gnihr was observed. In the gonads, lh (only in male fish) and fsh receptor mRNAs were also significantly downregulated in Nlp-injected fish. Sex-specific modulation of gnih, gnihr, and kisspeptin system in the gonads was also observed. Nlp decreased sex steroidogenic enzyme encoding mRNAs and circulating levels of testosterone and estradiol. In addition, incubation of zebrafish ovarian follicles with Nlp resulted in a reduction in oocyte maturation. These results provide evidence for a robust role for Nlp in regulating reproductive hormones in goldfish and oocyte maturation in zebrafish, and these effects resemble that of nesfatin-1.Summary SentenceNesfatin-1-like peptide is a negative modulator of reproduction in goldfish.
Biology of Reproduct... arrow_drop_down Biology of ReproductionArticle . 2020 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/biolre/ioaa106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology of Reproduct... arrow_drop_down Biology of ReproductionArticle . 2020 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/biolre/ioaa106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2009Publisher:Wiley Funded by:NSERC, CIHRNSERC ,CIHRAuthors: J Jean, Chen; G Bruce, Pike;J Jean, Chen; G Bruce, Pike;doi: 10.1002/nbm.1411
pmid: 19598180
AbstractTo understand and predict the blood‐oxygenation level‐dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (ΔCBF) and volume (ΔCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power‐law, derived from primate data, where the power coefficient (α) was found to be 0.38. The validity of this general formulation has been examined previously, and an α of 0.38 has been frequently cited when calculating the cerebral oxygen metabolism change (ΔCMRo2) using calibrated BOLD. However, the direct use of this relationship has been the subject of some debate, since it is well established that the BOLD signal is primarily modulated by changes in ‘venous’ CBV (ΔCBVv, comprising deoxygenated blood in the capillary, venular, and to a lesser extent, in the arteriolar compartments) instead of total CBV, and yet ΔCBVv measurements in humans have been extremely scarce. In this work, we demonstrate reproducible ΔCBVv measurements at 3 T using venous refocusing for the volume estimation (VERVE) technique, and report on steady‐state ΔCBVv and ΔCBF measurements in human subjects undergoing graded visual and sensorimotor stimulation. We found that: (1) a BOLD‐specific flow‐volume power‐law relationship is described by α = 0.23 ± 0.05, significantly lower than Grubb's constant of 0.38 for total CBV; (2) this power‐law constant was not found to vary significantly between the visual and sensorimotor areas; and (3) the use of Grubb's value of 0.38 in gradient‐echo BOLD modeling results in an underestimation of ΔCMRo2. Copyright © 2009 John Wiley & Sons, Ltd.
NMR in Biomedicine arrow_drop_down NMR in BiomedicineArticle . 2009 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 138 citations 138 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NMR in Biomedicine arrow_drop_down NMR in BiomedicineArticle . 2009 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Wiley Funded by:NSERCNSERCSamantha Cote; Russell Butler; Vincent Michaud; Eric Lavallee; Etienne Croteau; Adrianna Mendrek; Jean-François Lepage; Kevin Whittingstall;Abstract Sex hormones estrogen (EST) and progesterone (PROG) have received increased attention for their important physiological action outside of reproduction. While studies have shown that EST and PROG have significant impacts on brain function, their impact on the cerebrovascular system in humans remains largely unknown. To address this, we used a multi‐modal magnetic resonance imaging (MRI) approach to investigate the link between serum hormones in the follicular phase and luteal phase of the menstrual cycle (MC) with measures of cerebrovascular function (cerebral blood flow [CBF]) and structure (intracranial artery diameter). Fourteen naturally cycling women were recruited and assessed at two‐time points of their MC. CBF was derived from pseudo‐continuous arterial spin labeling while diameters of the internal carotid and basilar artery was assessed using time of flight magnetic resonance angiography, blood samples were performed after the MRI. Results show that PROG and EST had opposing and spatially distinct effects on CBF: PROG correlated negatively with CBF in anterior brain regions (r = −.86, p < .01), while EST correlations were positive, yet weak and most prominent in posterior areas (r = .78, p < .01). No significant correlations between either hormone or intracranial artery diameter were observed. These results show that EST and PROG have opposing and regionally distinct effects on CBF and that this relationship is likely not due to interactions with large intracranial arteries. Considering that CBF in healthy women appears tightly linked to their current hormonal state, future studies should consider assessing MC‐related hormone fluctuations in the design of functional MRI studies in this population. Using multi‐modal magnetic resonance imaging (MRI) we investigated the influence of serum hormones on cerebrovascular function and structure in naturally cycling, non‐pregnant women. We observed that progesterone has a strong negative correlation with CBF while estrogen had a weak positive association with CBF that was independent of large artery structure. These results highlight the impact that menstrual cycle‐related hormone fluctuations have on the female brain.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8559491Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hbm.25646&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8559491Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hbm.25646&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object 2004Embargo end date: 01 Jan 2004 FrancePublisher:arXiv Funded by:NSERCNSERCSajina, Anna; Scott, Douglas; Dennefeld, Michel; Dole, Herve; Lacy, Mark; Lagache, Guilaine;We present preliminary results on a study of the 2--850 micron SEDs of a sample of 30 FIRBACK galaxies selected at 170 micron. These sources are representative of the brightest ~10% of the Cosmic Infrared Background. They are a mixture of mostly local (z<~0.3) starforming galaxies, and a tail of ULIGs that extend up to z~1, and are likely to be a similar population to faint SCUBA sources. We use archival Spitzer IRAC and MIPS data to extend the spectral coverage to the mid-IR regime, resulting in an unprecended (for this redshift range) census of their infrared SEDs. This allows us to study in far greater detail this important population linking the near-IR stellar emission with PAH and thermal dust emission. We do this using a Markov Chain Monte Carlo method, which easily allows for the inclusion of ~6 free parameters, as well as an estimate of parameter uncertainties and correlations. 5 pages, 3 figures. Proceeding for the conference \"Starbursts: From 30 Doradus to Lyman Break Galaxies\", held in Cambridge (UK) in September, 2004
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2004Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2004License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Conference object . 2005Mémoires en Sciences de l'Information et de la Communication; HAL-UPMCConference object . 2005add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.astro-ph/0412394&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2004Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2004License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Conference object . 2005Mémoires en Sciences de l'Information et de la Communication; HAL-UPMCConference object . 2005add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.astro-ph/0412394&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017Publisher:Elsevier BV Funded by:NSERCNSERCAuthors: Manon, Maheux; Pierre, Jolicœur;Manon, Maheux; Pierre, Jolicœur;pmid: 28137452
We examined the role of attention and visual working memory in the evaluation of the number of target stimuli as well as their relative spatial position using the N2pc and the SPCN. Participants performed two tasks: a simple counting task in which they had to determine if a visual display contained one or two coloured items among grey fillers and one in which they had to identify a specific relation between two coloured items. The same stimuli were used for both tasks. Each task was designed to permit an easier evaluation of either the same-coloured or differently-coloured stimuli. We predicted a greater involvement of attention and visual working memory for more difficult stimulus-task pairings. The results confirmed these predictions and suggest that visuospatial configurations that require more time to evaluate induce a greater (and presumably longer) involvement of attention and visual working memory.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biopsycho.2017.01.011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biopsycho.2017.01.011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Publisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:UKRI | Imaging prognostic marker..., NIH | ENIGMA-COINSTAC: Advanced..., NIH | ENIGMA World Aging Center +15 projectsUKRI| Imaging prognostic markers for surgical seizure control in medically intractable temporal lobe epilepsy ,NIH| ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain CircuitsPD ,NIH| ENIGMA World Aging Center ,NSERC ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,UKRI| Brain architecture and connectivity at epilepsy diagnosis: markers of cognitive dysfunction and pharmacoresistance ,NIH| Predicting Epilepsy Surgery Outcomes Using Neural Network Architecture ,NIH| Prediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy study ,UKRI| Translation of novel imaging techniques into clinical use for patients with epilepsy ,NIH| ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA ,CIHR ,NIH| Multimodal imaging of cognitive networks in epilepsy: Implications for surgery ,NIH| SOLAR-Eclipse Computational Tools for Imaging Genetics ,NIH| High resolution mapping of the genetic risk for disease in the aging brain ,NIH| A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA Consortium ,NHMRC| Human Epilepsy: Understanding biology to improve outcomes ,SFI| FutureNeuro ,NIH| Laboratory of Neuro Imaging Resource (LONIR)Hatton, Sean N; Huynh, Khoa H; Bonilha, Leonardo; Abela, Eugenio; Alhusaini, Saud; Altmann, Andre; Alvim, Marina KM; Balachandra, Akshara R; Bartolini, Emanuele; Bender, Benjamin; Bernasconi, Neda; Bernasconi, Andrea; Bernhardt, Boris; Bargallo, Núria; Caldairou, Benoit; Caligiuri, Maria Eugenia; Carr, Sarah JA; Cavalleri, Gianpiero L; Cendes, Fernando; Concha, Luis; Davoodi-bojd, Esmaeil; Desmond, Patricia M; Devinsky, Orrin; Doherty, Colin P; Domin, Martin; Duncan, John S; Focke, Niels K; Foley, Sonya F; Gambardella, Antonio; Gleichgerrcht, Ezequiel; Guerrini, Renzo; Hamandi, Khalid; Ishikawa, Akaria; Keller, Simon S; Kochunov, Peter V; Kotikalapudi, Raviteja; Kreilkamp, Barbara AK; Kwan, Patrick; Labate, Angelo; Langner, Soenke; Lenge, Matteo; Liu, Min; Lui, Elaine; Martin, Pascal; Mascalchi, Mario; Moreira, José CV; Morita-Sherman, Marcia E; O’Brien, Terence J; Pardoe, Heath R; Pariente, José C; Ribeiro, Letícia F; Richardson, Mark P; Rocha, Cristiane S; Rodríguez-Cruces, Raúl; Rosenow, Felix; Severino, Mariasavina; Sinclair, Benjamin; Soltanian-Zadeh, Hamid; Striano, Pasquale; Taylor, Peter N; Thomas, Rhys H; Tortora, Domenico; Velakoulis, Dennis; Vezzani, Annamaria; Vivash, Lucy; von Podewils, Felix; Vos, Sjoerd B; Weber, Bernd; Winston, Gavin P; Yasuda, Clarissa L; Thompson, Paul M; Jahanshad, Neda; Sisodiya, Sanjay M; McDonald, Carrie R;AbstractThe epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2015 FrancePublisher:Elsevier BV Funded by:NSERCNSERCBureau Du Colombier, Sarah; Jacobs, Louis; Gesset, Charline; Elie, Pierre; Lambert, Patrick;[Departement_IRSTEA]Eaux [TR1_IRSTEA]QUASARE; International audience; In the context of the severe decrease in temperate eel abundance, understanding and control of eel maturation has strong interest for scientific and commercial purposes. Possible use of ultrasonography for improvement of sex determination and maturation monitoring in silver eel was investigated. Gonads of 96 Anguilla anguilla silver eels were observed using portable equipment associated to a 6-15MHz probe, and sex determination was tried before artificial induction of maturation. To estimate gonad mass and monitor individual gonadosomatic index (GSI) in females, cross-sectional images were captured at different times of maturation and gonad length was measured at scanning. Two methods were tried for ovary mass estimation using ultrasonography: one based on a linear model and another on calculating ovary volume from a representation of gonad shape. Ultrasonography resulted in 100% success in sex determination. Ovary mass estimated by ultrasonography was strongly correlated to true ovary mass (R2=0.97). The use of a linear model for gonad mass and then GSI estimation seemed more appropriate than the use of a representation of gonad shape. Evolution of GSI estimates during maturation supports possible detection of early inter-individual differences in maturation using ultrasonography in female silver eels. This non-invasive tool can then obviously be exploited to improve sex determination in silver eels caught in the wild and to monitor maturation at the individual level. Ultrasonography thus has great potential for use in eel both for conservation and aquaculture. To our knowledge, this is the first report on the use of ultrasonography on eels or any anguillid species.
Fisheries Research arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fishres.2014.10.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Fisheries Research arrow_drop_down Hyper Article en Ligne; Mémoires en Sciences de l'Information et de la Communication; Hal-DiderotOther literature type . Article . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fishres.2014.10.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2012 France EnglishPublisher:HAL CCSD Funded by:NSERCNSERCHarrap, Rob; DANIEL, Sylvie; Power, Michael; Pearce, Joshua M.; Hedley, Nicholas;International audience; Research networks foster creativity and break down institutional barriers, but introduce new geographic barriers to communication and collaboration. In designing mobile educational games, our distributed team took advantage of diverse talent pools and differing perspectives to drive forward a core vision of our overarching design targets. Our strategies included intense design workshops, use of online meeting rooms, paper and software prototyping as group activities, and dissemination of prototypes to other teams for refinement and repurposing. Our group showed strong activity at the university-centered nodes with periods of highly effective dissemination between these nodes and to outside groups; we used workshop invitations to gather new ideas and perspectives , to refine the vision, to forge inter-project links, and to stay current on what was happening in other networks. Several important aspects of our final deliverables came from loosely associated network members who engaged via collaborative design exercises in workshops, emphasizing the need to bring the network together and the importance of outside influences as ideas evolve. Our final deliverables demonstrate how our network both maintained a consistent vision and incorporated new ideas in the design of mobile augmented reality games, how our network experienced a new open approach of knowledge and technology sharing towards the sustainability of our research outcomes.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______177::300d0052834ff5f6b25357d8c9de3dcd&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______177::300d0052834ff5f6b25357d8c9de3dcd&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2016Publisher:Cold Spring Harbor Laboratory Funded by:NSERC, CIHR, NIH | Neuroinformatics for gene... +2 projectsNSERC ,CIHR ,NIH| Neuroinformatics for gene expression: networks, function and meta-analysis ,NIH| Integrative Meta-analysis of Microarray Data ,NIH| Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major DepressionB. Ogan Mancarci; Lilah Toker; Shreejoy J. Tripathy; Brenna Li; Brad R. Rocco; Etienne Sibille; Paul Pavlidis;Establishing the molecular diversity of cell types is crucial for the study of the nervous system. We compiled a cross-laboratory database of mouse brain cell type-specific transcriptomes from 36 major cell types from across the mammalian brain using rigorously curated published data from pooled cell type microarray and single-cell RNA-sequencing (RNA-seq) studies. We used these data to identify cell type-specific marker genes, discovering a substantial number of novel markers, many of which we validated using computational and experimental approaches. We further demonstrate that summarized expression of marker gene sets (MGSs) in bulk tissue data can be used to estimate the relative cell type abundance across samples. To facilitate use of this expanding resource, we provide a user-friendly web interface at www.neuroexpresso.org. Visual Abstract
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5707795Data sources: PubMed CentralbioRxivPreprint . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/089219&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 122 citations 122 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5707795Data sources: PubMed CentralbioRxivPreprint . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/089219&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2020Publisher:Cold Spring Harbor Laboratory Funded by:NSERCNSERCAuthors: Grecias, Lucie; Hebert, Francois Olivier; Alves, Verônica Angelica; Barber, Iain; +1 AuthorsGrecias, Lucie; Hebert, Francois Olivier; Alves, Verônica Angelica; Barber, Iain; Aubin-Horth, Nadia;ABSTRACTMany parasites with complex life cycles modify their intermediate hosts’ behaviour, presumably to increase transmission to their final host. The threespine stickleback (Gasterosteus aculeatus) is an intermediate host in the cestodeSchistocephalus soliduslife cycle, which ends in an avian host, and shows increased risky behaviours when infected. We studied brain gene expression profiles of sticklebacks infected withS.solidusto determine the proximal causes of these behavioural alterations. We show that infected fish have altered expression levels in genes involved in the inositol pathway. We thus tested the functional implication of this pathway and successfully rescued normal behaviours in infected sticklebacks using lithium exposure. We also show that exposed but uninfected fish have a distinct gene expression profile from both infected fish and control individuals, allowing us to separate gene activity related to parasite exposure from consequences of a successful infection. Finally, we find that Selective Serotonin Reuptake Inhibitor (SSRI)-treated sticklebacks and infected fish do not have similarly altered gene expression, despite their comparable behaviours, suggesting that the serotonin pathway is probably not the main driver of phenotypic changes in infected sticklebacks. Taken together, our results allow us to predict that ifS.solidusdirectly manipulates its host, it could target the inositol pathway.
bioRxiv arrow_drop_down bioRxivPreprint . 2020Proceedings of the Royal Society B Biological SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.08.084764&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert bioRxiv arrow_drop_down bioRxivPreprint . 2020Proceedings of the Royal Society B Biological SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2020.05.08.084764&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Oxford University Press (OUP) Funded by:NSERCNSERCAuthors: Jithine Jayakumar Rajeswari; Azadeh Hatef; Suraj Unniappan;Jithine Jayakumar Rajeswari; Azadeh Hatef; Suraj Unniappan;pmid: 32542346
Nucleobindin (Nucb)-1 and Nucb2 are DNA and Ca2+ binding proteins with multiple functions in vertebrates. Prohormone convertase-mediated processing of Nucb2 results in the production of biologically active nesfatin-1. Nesfatin-1 is involved in the regulation of reproduction in many vertebrates, including fish. Our lab originally reported a nesfatin-1-like peptide (Nlp) encoded in Nucb1 that exhibits nesfatin-1-like metabolic effects. We hypothesized that Nlp has a suppressive role in the reproductive physiology of fish. In this research, whether Nlp regulates reproductive hormones and oocyte maturation in fish were determined. Single intraperitoneal (IP) injection of goldfish Nlp (50 ng/g body weight) suppressed salmon and chicken gonadotropin-releasing hormone (sgnrh and cgnrh2), gonadotropin-inhibiting hormone (gnih) and its receptor (gnihr), and kisspeptin and brain aromatase mRNA expression in the hypothalamus of both male and female goldfish. In the pituitary, Nlp decreased mRNAs encoding lhb, fshb and kisspeptin and its receptor, while a significant increase in gnih and gnihr was observed. In the gonads, lh (only in male fish) and fsh receptor mRNAs were also significantly downregulated in Nlp-injected fish. Sex-specific modulation of gnih, gnihr, and kisspeptin system in the gonads was also observed. Nlp decreased sex steroidogenic enzyme encoding mRNAs and circulating levels of testosterone and estradiol. In addition, incubation of zebrafish ovarian follicles with Nlp resulted in a reduction in oocyte maturation. These results provide evidence for a robust role for Nlp in regulating reproductive hormones in goldfish and oocyte maturation in zebrafish, and these effects resemble that of nesfatin-1.Summary SentenceNesfatin-1-like peptide is a negative modulator of reproduction in goldfish.
Biology of Reproduct... arrow_drop_down Biology of ReproductionArticle . 2020 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/biolre/ioaa106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Biology of Reproduct... arrow_drop_down Biology of ReproductionArticle . 2020 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/biolre/ioaa106&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2009Publisher:Wiley Funded by:NSERC, CIHRNSERC ,CIHRAuthors: J Jean, Chen; G Bruce, Pike;J Jean, Chen; G Bruce, Pike;doi: 10.1002/nbm.1411
pmid: 19598180
AbstractTo understand and predict the blood‐oxygenation level‐dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (ΔCBF) and volume (ΔCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power‐law, derived from primate data, where the power coefficient (α) was found to be 0.38. The validity of this general formulation has been examined previously, and an α of 0.38 has been frequently cited when calculating the cerebral oxygen metabolism change (ΔCMRo2) using calibrated BOLD. However, the direct use of this relationship has been the subject of some debate, since it is well established that the BOLD signal is primarily modulated by changes in ‘venous’ CBV (ΔCBVv, comprising deoxygenated blood in the capillary, venular, and to a lesser extent, in the arteriolar compartments) instead of total CBV, and yet ΔCBVv measurements in humans have been extremely scarce. In this work, we demonstrate reproducible ΔCBVv measurements at 3 T using venous refocusing for the volume estimation (VERVE) technique, and report on steady‐state ΔCBVv and ΔCBF measurements in human subjects undergoing graded visual and sensorimotor stimulation. We found that: (1) a BOLD‐specific flow‐volume power‐law relationship is described by α = 0.23 ± 0.05, significantly lower than Grubb's constant of 0.38 for total CBV; (2) this power‐law constant was not found to vary significantly between the visual and sensorimotor areas; and (3) the use of Grubb's value of 0.38 in gradient‐echo BOLD modeling results in an underestimation of ΔCMRo2. Copyright © 2009 John Wiley & Sons, Ltd.
NMR in Biomedicine arrow_drop_down NMR in BiomedicineArticle . 2009 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 138 citations 138 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NMR in Biomedicine arrow_drop_down NMR in BiomedicineArticle . 2009 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.1411&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021Publisher:Wiley Funded by:NSERCNSERCSamantha Cote; Russell Butler; Vincent Michaud; Eric Lavallee; Etienne Croteau; Adrianna Mendrek; Jean-François Lepage; Kevin Whittingstall;Abstract Sex hormones estrogen (EST) and progesterone (PROG) have received increased attention for their important physiological action outside of reproduction. While studies have shown that EST and PROG have significant impacts on brain function, their impact on the cerebrovascular system in humans remains largely unknown. To address this, we used a multi‐modal magnetic resonance imaging (MRI) approach to investigate the link between serum hormones in the follicular phase and luteal phase of the menstrual cycle (MC) with measures of cerebrovascular function (cerebral blood flow [CBF]) and structure (intracranial artery diameter). Fourteen naturally cycling women were recruited and assessed at two‐time points of their MC. CBF was derived from pseudo‐continuous arterial spin labeling while diameters of the internal carotid and basilar artery was assessed using time of flight magnetic resonance angiography, blood samples were performed after the MRI. Results show that PROG and EST had opposing and spatially distinct effects on CBF: PROG correlated negatively with CBF in anterior brain regions (r = −.86, p < .01), while EST correlations were positive, yet weak and most prominent in posterior areas (r = .78, p < .01). No significant correlations between either hormone or intracranial artery diameter were observed. These results show that EST and PROG have opposing and regionally distinct effects on CBF and that this relationship is likely not due to interactions with large intracranial arteries. Considering that CBF in healthy women appears tightly linked to their current hormonal state, future studies should consider assessing MC‐related hormone fluctuations in the design of functional MRI studies in this population. Using multi‐modal magnetic resonance imaging (MRI) we investigated the influence of serum hormones on cerebrovascular function and structure in naturally cycling, non‐pregnant women. We observed that progesterone has a strong negative correlation with CBF while estrogen had a weak positive association with CBF that was independent of large artery structure. These results highlight the impact that menstrual cycle‐related hormone fluctuations have on the female brain.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8559491Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hbm.25646&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8559491Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hbm.25646&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object 2004Embargo end date: 01 Jan 2004 FrancePublisher:arXiv Funded by:NSERCNSERCSajina, Anna; Scott, Douglas; Dennefeld, Michel; Dole, Herve; Lacy, Mark; Lagache, Guilaine;We present preliminary results on a study of the 2--850 micron SEDs of a sample of 30 FIRBACK galaxies selected at 170 micron. These sources are representative of the brightest ~10% of the Cosmic Infrared Background. They are a mixture of mostly local (z<~0.3) starforming galaxies, and a tail of ULIGs that extend up to z~1, and are likely to be a similar population to faint SCUBA sources. We use archival Spitzer IRAC and MIPS data to extend the spectral coverage to the mid-IR regime, resulting in an unprecended (for this redshift range) census of their infrared SEDs. This allows us to study in far greater detail this important population linking the near-IR stellar emission with PAH and thermal dust emission. We do this using a Markov Chain Monte Carlo method, which easily allows for the inclusion of ~6 free parameters, as well as an estimate of parameter uncertainties and correlations. 5 pages, 3 figures. Proceeding for the conference \"Starbursts: From 30 Doradus to Lyman Break Galaxies\", held in Cambridge (UK) in September, 2004
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2004Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2004License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Conference object . 2005Mémoires en Sciences de l'Information et de la Communication; HAL-UPMCConference object . 2005add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.astro-ph/0412394&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2004Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2004License: arXiv Non-Exclusive DistributionData sources: DataciteHyper Article en Ligne; Hal-DiderotOther literature type . Conference object . 2005Mémoires en Sciences de l'Information et de la Communication; HAL-UPMCConference object . 2005add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.astro-ph/0412394&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017Publisher:Elsevier BV Funded by:NSERCNSERCAuthors: Manon, Maheux; Pierre, Jolicœur;Manon, Maheux; Pierre, Jolicœur;pmid: 28137452
We examined the role of attention and visual working memory in the evaluation of the number of target stimuli as well as their relative spatial position using the N2pc and the SPCN. Participants performed two tasks: a simple counting task in which they had to determine if a visual display contained one or two coloured items among grey fillers and one in which they had to identify a specific relation between two coloured items. The same stimuli were used for both tasks. Each task was designed to permit an easier evaluation of either the same-coloured or differently-coloured stimuli. We predicted a greater involvement of attention and visual working memory for more difficult stimulus-task pairings. The results confirmed these predictions and suggest that visuospatial configurations that require more time to evaluate induce a greater (and presumably longer) involvement of attention and visual working memory.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biopsycho.2017.01.011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biopsycho.2017.01.011&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Publisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:UKRI | Imaging prognostic marker..., NIH | ENIGMA-COINSTAC: Advanced..., NIH | ENIGMA World Aging Center +15 projectsUKRI| Imaging prognostic markers for surgical seizure control in medically intractable temporal lobe epilepsy ,NIH| ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain CircuitsPD ,NIH| ENIGMA World Aging Center ,NSERC ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,UKRI| Brain architecture and connectivity at epilepsy diagnosis: markers of cognitive dysfunction and pharmacoresistance ,NIH| Predicting Epilepsy Surgery Outcomes Using Neural Network Architecture ,NIH| Prediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy study ,UKRI| Translation of novel imaging techniques into clinical use for patients with epilepsy ,NIH| ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMA ,CIHR ,NIH| Multimodal imaging of cognitive networks in epilepsy: Implications for surgery ,NIH| SOLAR-Eclipse Computational Tools for Imaging Genetics ,NIH| High resolution mapping of the genetic risk for disease in the aging brain ,NIH| A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA Consortium ,NHMRC| Human Epilepsy: Understanding biology to improve outcomes ,SFI| FutureNeuro ,NIH| Laboratory of Neuro Imaging Resource (LONIR)Hatton, Sean N; Huynh, Khoa H; Bonilha, Leonardo; Abela, Eugenio; Alhusaini, Saud; Altmann, Andre; Alvim, Marina KM; Balachandra, Akshara R; Bartolini, Emanuele; Bender, Benjamin; Bernasconi, Neda; Bernasconi, Andrea; Bernhardt, Boris; Bargallo, Núria; Caldairou, Benoit; Caligiuri, Maria Eugenia; Carr, Sarah JA; Cavalleri, Gianpiero L; Cendes, Fernando; Concha, Luis; Davoodi-bojd, Esmaeil; Desmond, Patricia M; Devinsky, Orrin; Doherty, Colin P; Domin, Martin; Duncan, John S; Focke, Niels K; Foley, Sonya F; Gambardella, Antonio; Gleichgerrcht, Ezequiel; Guerrini, Renzo; Hamandi, Khalid; Ishikawa, Akaria; Keller, Simon S; Kochunov, Peter V; Kotikalapudi, Raviteja; Kreilkamp, Barbara AK; Kwan, Patrick; Labate, Angelo; Langner, Soenke; Lenge, Matteo; Liu, Min; Lui, Elaine; Martin, Pascal; Mascalchi, Mario; Moreira, José CV; Morita-Sherman, Marcia E; O’Brien, Terence J; Pardoe, Heath R; Pariente, José C; Ribeiro, Letícia F; Richardson, Mark P; Rocha, Cristiane S; Rodríguez-Cruces, Raúl; Rosenow, Felix; Severino, Mariasavina; Sinclair, Benjamin; Soltanian-Zadeh, Hamid; Striano, Pasquale; Taylor, Peter N; Thomas, Rhys H; Tortora, Domenico; Velakoulis, Dennis; Vezzani, Annamaria; Vivash, Lucy; von Podewils, Felix; Vos, Sjoerd B; Weber, Bernd; Winston, Gavin P; Yasuda, Clarissa L; Thompson, Paul M; Jahanshad, Neda; Sisodiya, Sanjay M; McDonald, Carrie R;AbstractThe epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2019.12.19.883405&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2019.12.19.883405&type=result"></script>'); --> </script>
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