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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mientjes, E.J.; Steenwinkel, M.J.S.T.; Delft, J.H.M. van; Lohman, P.H.M.; +1 Authors

    The recent introduction of the phenyl-β-D-galactopyranoside (P-gal)-based positive-selection system for screening of λlacZ phages originating from the λlacZ transgenic mouse (Muta Mouse) has made the determination of mutant frequencies (MF) a much simpler task. Previously, MF data from these mice have been collected by means of the 5-bromo-4-chloro-3- indolyl-β-D-galactopyranoside (X-gal) colour-screening procedure. To determine whether data obtained with the two systems are comparable, the MF in h phages recovered from liver and brain of transgenic mice treated with N-ethyl-N-nitrosourea (ENU) and liver of benzo(a)pyrene (B(α)P)-treated mice was determined with both procedures. For the livers of mice treated with ENU, both methods yielded approximately the same MF values. No induction of mutants, relative to the control animals, was seen after 1.5 h, but a clear 4-fold increase was measured with both assays at the 14-day time point. No induction of mutants was found in the brain with either method. In the B(α)P-treated mice, both methods showed a substantial induction in MF after 21, 28 and 35 days. The values generated by the X-gal and P-gal methods were not significantly different, with the exception of the 35-day post-treatment point that appeared higher in the X-gal assay. When the mutants isolated by use of the X-gal method were tested in the P-gal assay, a number of these did not turn up as mutants, and the significance disappeared, In conclusion, the data obtained with the two screening procedures agree to such an extent as to permit a direct comparison between the earlier results generated with X-gal and P-gal values generated with the new positive-selection method. This is likely to apply also to other organs and mutagens than those studied here.

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    Authors: Aytekin, Emine; Bostan, Mine,;

    International audience; The study attempted to investigate the ways a prospective teacher, Elif, responded to contingent moments in her teaching practice. In addition, her perceptions regarding changes in the nature of the tasks based on the students’ unanticipated thinking after the teaching were examined. Elif attended to a two-hour class of teaching seminar in which categorizations of mathematical tasks were presented. Then, during her enrollment in teaching practicum course, she taught a lesson on algebra by considering the categorization of the tasks. The lesson plan, her video record of teaching, semi-structured pre and post interviews were analyzed based on contingent trigger categories and kinds of teachers’ responses to them and tasks during the phase of selecting, enacting and revising were analyzed based on its cognitive demand. Results showed that the contingent moments lead her to reanalyze the content and implementation of the designed tasks for further teaching.

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    Other literature type . 2019
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    Authors: Gamze, Kurt;

    International audience; This study explores the informal statistical inference (ISI) experiences through the graph construction of young children regarding the pictograph as one of the conventional data displays. Within a case study approach, interviews with 7 years-old children were conducted through a module including a task. The task designed here presents a statistical context structure which focuses on the eye colors observed in a class. Through forming a pictograph, children responded the questions in order to investigate their informal inferential reasoning ability. Findings revealed that young children’s graph construction experiences could be expressed as a construct of ISI. Besides, it was concluded that the integration of context with data helped their graph construction since they analyzed data within the context.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Maumet, Camille;

    Cette thèse aborde l'étude de la fonction cérébrale en Imagerie par Résonance Magnétique (IRM) à l'aide de deux séquences : l'IRM fonctionnelle (IRMf) BOLD et l'imagerie de perfusion par marquage de spins (ASL). Dans ce contexte, les analyses de groupe jouent un rôle important dans l'identification des dysfonctionnements globaux associés à une pathologie. D'autre part, les études individuelles, qui fournissent des conclusions au niveau d'un sujet unique, présentent un intérêt croissant. Dans ce travail, nous abordons à la fois les études de groupe et les analyses individuelles. Dans un premier temps, nous réalisons une analyse de groupe en IRMf BOLD en vue d'étudier la dysphasie chez l'enfant, une pathologie peu explorée en neuroimagerie. Nous mettons ainsi en évidence un fonctionnement et une latéralisation atypiques des aires langagières. Ensuite, nous nous concentrons sur les analyses individuelles. Nous proposons l'utilisation d'estimateurs robustes pour calculer les cartographies de débit sanguin cérébral en ASL. Ensuite, nous étudions la validité des hypothèses qui sous-tendent les analyses statistiques standard dans le contexte de l'ASL. Finalement, nous proposons une nouvelle méthode localement multivariée basée sur une approche a contrario. La validation de cette nouvelle approche est réalisée dans deux contextes applicatifs : la détection d'anomalies de perfusion en ASL et la détection de zones d'activation en IRMf BOLD. This thesis deals with the analysis of brain function in Magnetic Resonance Imaging (MRI) using two sequences: BOLD functional MRI (fMRI) and Arterial Spin Labelling (ASL). In this context, group statistical analyses are of great importance in order to understand the general mechanisms underlying a pathology, but there is also an increasing interest towards patient-specific analyses that draw conclusions at the patient level. Both group and patient-specific analyses are studied in this thesis. We first introduce a group analysis in BOLD fMRI for the study of specific language impairment, a pathology that was very little investigated in neuroimaging. We outline atypical patterns of functional activity and lateralisation in language regions. Then, we move forward to patient-specific analysis. We propose the use of robust estimators to compute cerebral blood flow maps in ASL. Then, we analyse the validity of the assumptions underlying standard statistical analyses in the context of ASL. Finally, we propose a new locally multivariate statistical method based on an a contrario approach and apply it to the detection of atypical patterns of perfusion in ASL and to activation detection in BOLD functional MRI.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hyper Article en Lig...arrow_drop_down
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    Other literature type . 2013
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    Authors: Sun, Delin; Rakesh, Gopalkumar; Clarke-Rubright, Emily K; Haswell, Courtney C; +91 Authors

    BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). METHODS: Neuroimaging and clinical data were aggregated from 29 research sites in >1,300 PTSD cases and >2,000 trauma-exposed controls (age 6.2–85.2 years) by the ENIGMA-PGC PTSD working group. Cortical regions in the network were rank-ordered by effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2 to 148) regions with the largest between-group differences in effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared to the mean SC of 5,000 randomly generated n-region networks. For methodologic confirmation we demonstrated that PTSD patients had higher mean SC as compared to random networks in CT-based and SA-based atrophic networks, CT-based and SA-based hypertrophic networks, and CT-based stable networks. We also confirmed that non-PTSD participants showed higher mean SC than random networks in CT-based and SA-based atrophic networks, and SA-based hypertrophic networks. RESULTS: Patients with PTSD, relative to non-PTSD controls, exhibited lower mean SC in CT-based and SA-based atrophic networks. Patients with PTSD alone showed lower mean SC in CT-based atrophic networks than patients with depression alone, and higher mean SC in SA-based atrophic networks than PTSD patients with comorbid depression as well as healthy controls. Sex and age modulated covariance differences of PTSD-related structural networks. CONCLUSIONS: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The structural covariance networks that are perturbed in PTSD comport with converging evidence from resting state functional connectivity networks and networks impacted by inflammatory processes, and stress hormones in PTSD.

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    Article . 2022
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    Europe PubMed Central
    Other literature type . 2022
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    Authors: Kalz, Marco; Drachsler, Hendrik; Van Bruggen, Jan; Hummel, Hans; +1 Authors

    To choose suitable resources for personal competence development in the vast amount of open educational resources is a challenging task for a learner. Starting with a needs analysis of lifelong learners and learning designers we introduce two wayfinding services that are currently researched and developed in the framework of the Integrated Project TENCompetence. Then we discuss the role of these services to support learners in finding and selecting open educational resources and finally we give an outlook on future research.

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    Conference object . 2007
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    Authors: Allgower, C E.; Ball, J.; Beddo, M.; Bedfer, Y.; +29 Authors
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    Article . 1998
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      Article . 1998
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    Authors: Ubilla, Francisca; Gorgorió, Núria; Prat, Montserrat;

    International audience; With the aim of contributing to the study of the statistical knowledge of pre-service primary school teachers, here we present the creation of a system of categories of analysis to characterize the written reports of a group of students who carried out a task that reflected the five stages of the statistical investigative cycle. The analysis answers to a deductive/inductive process, since we look at the theory to understand our data and, at the same time, themes emerge that had not yet been described in the literature. Our contribution is a system of categories for the characterization of the statistical investigative cycle, which consolidates, refines and extends what has been published so far. The proposal presented here may be useful not only for researchers and teacher educators, but also for pre-service teachers themselves to understand the investigative cycle.

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    Other literature type . 2019
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    Other literature type . 2019
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    Authors: Acciarri, M; Adriani, O; Aguilar-Benítez, M; Ahlen, S P; +196 Authors

    A search for excited leptons $\rm e^*,~\mu^*, ~\tau^*$ and $\nu_{\rm e}^*$ in $\rm e^+e^-$ collisions at $\rm \sqrt{s}$ = 161 GeV is performed using the $\rm 10.8 ~pb^{-1}$ of data collected by the L3 detector at LEP. No evidence has been found for their existence. From an analysis of the expected $\ell^*\ell^*$ pair production in the channels $\rm ee\gamma\gamma$, $\rm \mu\mu\gamma\gamma$, $\rm \tau\tau\gamma\gamma$, $\rm eeWW$, and $\rm \nu\nu\gamma\gamma$, the lower mass limits at 95\% C.L. are 79.7 GeV for $\rm e^{*}$, 79.9 GeV for $\mu^{*}$, 79.3 GeV for $\tau^{*}$ and 71.3 GeV for $\nu_{\rm e}^{*}$ assuming the same couplings as for standard leptons. From an analysis of the expected $\ell\ell^*$ single production in channels $\rm ee\gamma$, $\mu\mu\gamma$, $ \tau\tau\gamma$, $\rm \nu_{e}eW$ and $\nu\nu\gamma$, the upper limits on the couplings $\lambda/m_{\ell^*}$ up to $m_{\ell^{*}}$ = 161 GeV are determined.

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    Article . 1997
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    Article . 1997
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    CERN Document Server
    Other literature type . 1997
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    Article . 1997
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      Article . 1997
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      Article . 1997
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      CERN Document Server
      Other literature type . 1997
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      Article . 1997
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    Authors: Helder, A.;

    When trying to understand texts, readers engage in various cognitive processes. If all goes well, the engagement in these cognitive processes during reading results in the construction of a coherent mental representation of the text, the essence of successful reading comprehension. To construct such a representation, readers need to monitor the coherence of the text and of their emerging mental representation of what the text is about. The central aim of the empirical studies described is to examine coherence-monitoring processes across development by measuring reader’s ability to detect coherence breaks during reading of narratives. The first part of this dissertation consists of three empirical studies (chapter 2-4). The first study examined whether good and poor comprehenders at age 8-9 and 10-11 detected coherence-breaks during and/or after reading. The second study builds on the first study by examining the protracted development of coherence monitoring in an adolescent population (ages 10-22) using the same task under more challenging circumstances. The third study explored the neural correlates of coherence-break detection in young adults in an fMRI study. The second part of this dissertation consists of two conceptual chapters in which the results are summarized and discussed in a broader theoretical perspective (chapter 5-6).

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    Doctoral thesis . 2016
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    Doctoral thesis . 2016
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      Doctoral thesis . 2016
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Mientjes, E.J.; Steenwinkel, M.J.S.T.; Delft, J.H.M. van; Lohman, P.H.M.; +1 Authors

    The recent introduction of the phenyl-β-D-galactopyranoside (P-gal)-based positive-selection system for screening of λlacZ phages originating from the λlacZ transgenic mouse (Muta Mouse) has made the determination of mutant frequencies (MF) a much simpler task. Previously, MF data from these mice have been collected by means of the 5-bromo-4-chloro-3- indolyl-β-D-galactopyranoside (X-gal) colour-screening procedure. To determine whether data obtained with the two systems are comparable, the MF in h phages recovered from liver and brain of transgenic mice treated with N-ethyl-N-nitrosourea (ENU) and liver of benzo(a)pyrene (B(α)P)-treated mice was determined with both procedures. For the livers of mice treated with ENU, both methods yielded approximately the same MF values. No induction of mutants, relative to the control animals, was seen after 1.5 h, but a clear 4-fold increase was measured with both assays at the 14-day time point. No induction of mutants was found in the brain with either method. In the B(α)P-treated mice, both methods showed a substantial induction in MF after 21, 28 and 35 days. The values generated by the X-gal and P-gal methods were not significantly different, with the exception of the 35-day post-treatment point that appeared higher in the X-gal assay. When the mutants isolated by use of the X-gal method were tested in the P-gal assay, a number of these did not turn up as mutants, and the significance disappeared, In conclusion, the data obtained with the two screening procedures agree to such an extent as to permit a direct comparison between the earlier results generated with X-gal and P-gal values generated with the new positive-selection method. This is likely to apply also to other organs and mutagens than those studied here.

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    Authors: Aytekin, Emine; Bostan, Mine,;

    International audience; The study attempted to investigate the ways a prospective teacher, Elif, responded to contingent moments in her teaching practice. In addition, her perceptions regarding changes in the nature of the tasks based on the students’ unanticipated thinking after the teaching were examined. Elif attended to a two-hour class of teaching seminar in which categorizations of mathematical tasks were presented. Then, during her enrollment in teaching practicum course, she taught a lesson on algebra by considering the categorization of the tasks. The lesson plan, her video record of teaching, semi-structured pre and post interviews were analyzed based on contingent trigger categories and kinds of teachers’ responses to them and tasks during the phase of selecting, enacting and revising were analyzed based on its cognitive demand. Results showed that the contingent moments lead her to reanalyze the content and implementation of the designed tasks for further teaching.

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    Authors: Gamze, Kurt;

    International audience; This study explores the informal statistical inference (ISI) experiences through the graph construction of young children regarding the pictograph as one of the conventional data displays. Within a case study approach, interviews with 7 years-old children were conducted through a module including a task. The task designed here presents a statistical context structure which focuses on the eye colors observed in a class. Through forming a pictograph, children responded the questions in order to investigate their informal inferential reasoning ability. Findings revealed that young children’s graph construction experiences could be expressed as a construct of ISI. Besides, it was concluded that the integration of context with data helped their graph construction since they analyzed data within the context.

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      Other literature type . 2019
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      Other literature type . 2019
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    Authors: Maumet, Camille;

    Cette thèse aborde l'étude de la fonction cérébrale en Imagerie par Résonance Magnétique (IRM) à l'aide de deux séquences : l'IRM fonctionnelle (IRMf) BOLD et l'imagerie de perfusion par marquage de spins (ASL). Dans ce contexte, les analyses de groupe jouent un rôle important dans l'identification des dysfonctionnements globaux associés à une pathologie. D'autre part, les études individuelles, qui fournissent des conclusions au niveau d'un sujet unique, présentent un intérêt croissant. Dans ce travail, nous abordons à la fois les études de groupe et les analyses individuelles. Dans un premier temps, nous réalisons une analyse de groupe en IRMf BOLD en vue d'étudier la dysphasie chez l'enfant, une pathologie peu explorée en neuroimagerie. Nous mettons ainsi en évidence un fonctionnement et une latéralisation atypiques des aires langagières. Ensuite, nous nous concentrons sur les analyses individuelles. Nous proposons l'utilisation d'estimateurs robustes pour calculer les cartographies de débit sanguin cérébral en ASL. Ensuite, nous étudions la validité des hypothèses qui sous-tendent les analyses statistiques standard dans le contexte de l'ASL. Finalement, nous proposons une nouvelle méthode localement multivariée basée sur une approche a contrario. La validation de cette nouvelle approche est réalisée dans deux contextes applicatifs : la détection d'anomalies de perfusion en ASL et la détection de zones d'activation en IRMf BOLD. This thesis deals with the analysis of brain function in Magnetic Resonance Imaging (MRI) using two sequences: BOLD functional MRI (fMRI) and Arterial Spin Labelling (ASL). In this context, group statistical analyses are of great importance in order to understand the general mechanisms underlying a pathology, but there is also an increasing interest towards patient-specific analyses that draw conclusions at the patient level. Both group and patient-specific analyses are studied in this thesis. We first introduce a group analysis in BOLD fMRI for the study of specific language impairment, a pathology that was very little investigated in neuroimaging. We outline atypical patterns of functional activity and lateralisation in language regions. Then, we move forward to patient-specific analysis. We propose the use of robust estimators to compute cerebral blood flow maps in ASL. Then, we analyse the validity of the assumptions underlying standard statistical analyses in the context of ASL. Finally, we propose a new locally multivariate statistical method based on an a contrario approach and apply it to the detection of atypical patterns of perfusion in ASL and to activation detection in BOLD functional MRI.

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    Other literature type . 2013
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    Authors: Sun, Delin; Rakesh, Gopalkumar; Clarke-Rubright, Emily K; Haswell, Courtney C; +91 Authors

    BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA). METHODS: Neuroimaging and clinical data were aggregated from 29 research sites in >1,300 PTSD cases and >2,000 trauma-exposed controls (age 6.2–85.2 years) by the ENIGMA-PGC PTSD working group. Cortical regions in the network were rank-ordered by effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2 to 148) regions with the largest between-group differences in effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared to the mean SC of 5,000 randomly generated n-region networks. For methodologic confirmation we demonstrated that PTSD patients had higher mean SC as compared to random networks in CT-based and SA-based atrophic networks, CT-based and SA-based hypertrophic networks, and CT-based stable networks. We also confirmed that non-PTSD participants showed higher mean SC than random networks in CT-based and SA-based atrophic networks, and SA-based hypertrophic networks. RESULTS: Patients with PTSD, relative to non-PTSD controls, exhibited lower mean SC in CT-based and SA-based atrophic networks. Patients with PTSD alone showed lower mean SC in CT-based atrophic networks than patients with depression alone, and higher mean SC in SA-based atrophic networks than PTSD patients with comorbid depression as well as healthy controls. Sex and age modulated covariance differences of PTSD-related structural networks. CONCLUSIONS: Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The structural covariance networks that are perturbed in PTSD comport with converging evidence from resting state functional connectivity networks and networks impacted by inflammatory processes, and stress hormones in PTSD.

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    Article . 2022
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    Europe PubMed Central
    Other literature type . 2022
    Data sources: PubMed Central
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      Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Other literature type . 2022
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    Authors: Kalz, Marco; Drachsler, Hendrik; Van Bruggen, Jan; Hummel, Hans; +1 Authors

    To choose suitable resources for personal competence development in the vast amount of open educational resources is a challenging task for a learner. Starting with a needs analysis of lifelong learners and learning designers we introduce two wayfinding services that are currently researched and developed in the framework of the Integrated Project TENCompetence. Then we discuss the role of these services to support learners in finding and selecting open educational resources and finally we give an outlook on future research.