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description Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United StatesPublisher:Elsevier BV Funded by:CIHRCIHRAuthors: Xia, Frances; Kheirbek, Mazen A.;Xia, Frances; Kheirbek, Mazen A.;Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.tins.2020.08.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.tins.2020.08.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012 Netherlands, Denmark, France, Spain, Denmark, FrancePublisher:Elsevier BV Funded by:NIH | Alzheimers Disease Neuroi..., CIHR, NIH | UC Davis Alzheimer's Core... +1 projectsNIH| Alzheimers Disease Neuroimaging Initiative ,CIHR ,NIH| UC Davis Alzheimer's Core Center ,NIH| "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"Eskildsen, S.F.; Coupe, P.; Fonov, V.; Manjon, J.V.; Leung, K.K.; Guizard, N.; Wassef, S.N.; Ostergaard, L.R.; Collins, D.L.; Olde Rikkert, M.; Olde Rikkert, M.; et al, .;Brain extraction is an important step in the analysis of brain images. The variability in brain morphology and the difference in intensity characteristics due to imaging sequences make the development of a general purpose brain extraction algorithm challenging. To address this issue, we propose a new robust method (BEaST) dedicated to produce consistent and accurate brain extraction. This method is based on nonlocal segmentation embedded in a multi-resolution framework. A library of 80 priors is semi-automatically constructed from the NIH-sponsored MRI study of normal brain development, the International Consortium for Brain Mapping, and the Alzheimer's Disease Neuroimaging Initiative databases. In testing, a mean Dice similarity coefficient of 0.9834 ± 0.0053 was obtained when performing leave-one-out cross validation selecting only 20 priors from the library. Validation using the online Segmentation Validation Engine resulted in a top ranking position with a mean Dice coefficient of 0.9781 ± 0.0047. Robustness of BEaST is demonstrated on all baseline ADNI data, resulting in a very low failure rate. The segmentation accuracy of the method is better than two widely used publicly available methods and recent state-of-the-art hybrid approaches. BEaST provides results comparable to a recent label fusion approach, while being 40 times faster and requiring a much smaller library of priors. Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., as well as non-profit partners the Alzheimer's Association and Alzheimer's Drug Discovery Foundation, with participation from the U.S. Food and Drug Administration. Private sector contributions to ADNI are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. This research was also supported by NIH grants P30AG010129, K01 AG030514, and the Dana Foundation.
Radboud Repository; ... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; METIS Research Information System; NeuroImageArticle . 2012 . Peer-reviewedLicense: Elsevier TDMVBN; Aalborg University Research PortalArticle . 2012VBN; Aalborg University Research PortalArticle . 2012HAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 388 citations 388 popularity Top 0.1% influence Top 1% impulse Top 1% Powered by BIP!visibility 197visibility views 197 download downloads 1,375 Powered bymore_vert Radboud Repository; ... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; METIS Research Information System; NeuroImageArticle . 2012 . Peer-reviewedLicense: Elsevier TDMVBN; Aalborg University Research PortalArticle . 2012VBN; Aalborg University Research PortalArticle . 2012HAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuroimage.2011.09.012&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012 Canada, FrancePublisher:Bentham Science Publishers Ltd. Funded by:CIHRCIHRAuthors: Annweiler, Cédric; Montero-Odasso, Manuel; Muir, S.; Beauchet, Olivier;Annweiler, Cédric; Montero-Odasso, Manuel; Muir, S.; Beauchet, Olivier;International audience; Hypovitaminosis D is associated with cognitive decline in the elderly, but the issue of causality remains unresolved. Definitive evidence would include the visualization of brain lesions resulting from hypovitaminosis D. The aim of the present article is to determine, through a literature review, the location and nature of possible brain disorders in hypovitaminosis D. We found limited brain-imaging data, which reported ischemic infarcts and white matter hyperintensities in hypovitaminosis D, though did not provide their specific location or report any focal atrophy. Based on the finding of executive dysfunctions (i.e., mental shifting and information updating impairments) in the presence of hypovitaminosis D, we suggest that hypovitaminosis D is associated with a dysfunction of the frontal-subcortical neuronal circuits, particularly the dorsolateral circuit. Further imaging studies are required to corroborate this assumption and to determine whether hypovitaminosis D results in degenerative and / or vascular lesions.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3296113Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874440001206010016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 26 citations 26 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3296113Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874440001206010016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010Publisher:Public Library of Science (PLoS) Funded by:NSERC, CIHRNSERC ,CIHRTaves, Matthew D.; Schmidt, Kim L.; Ruhr, Ilan M.; Kapusta, Katarzyna; Prior, Nora H.; Soma, Kiran K.;The brain and other organs locally synthesize steroids. Local synthesis is suggested when steroid levels are higher in tissue than in the circulation. However, measurement of both circulating and tissue steroid levels are subject to methodological considerations. For example, plasma samples are commonly used to estimate circulating steroid levels in whole blood, but steroid levels in plasma and whole blood could differ. In addition, tissue steroid measurements might be affected by blood contamination, which can be addressed experimentally by using saline perfusion to remove blood. In Study 1, we measured corticosterone and testosterone (T) levels in zebra finch (Taeniopygia guttata) plasma, whole blood, and red blood cells (RBC). We also compared corticosterone in plasma, whole blood, and RBC at baseline and after 60 min restraint stress. In Study 2, we quantified corticosterone, dehydroepiandrosterone (DHEA), T, and 17β-estradiol (E₂) levels in the brains of sham-perfused or saline-perfused subjects. In Study 1, corticosterone and T concentrations were highest in plasma, significantly lower in whole blood, and lowest in RBC. In Study 2, saline perfusion unexpectedly increased corticosterone levels in the rostral telencephalon but not other regions. In contrast, saline perfusion decreased DHEA levels in caudal telencephalon and diencephalon. Saline perfusion also increased E₂ levels in caudal telencephalon. In summary, when comparing local and systemic steroid levels, the inclusion of whole blood samples should prove useful. Moreover, blood contamination has little or no effect on measurement of brain steroid levels, suggesting that saline perfusion is not necessary prior to brain collection. Indeed, saline perfusion itself may elevate and lower steroid concentrations in a rapid, region-specific manner.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2010Full-Text: http://europepmc.org/articles/PMC3012083Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0015727&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 51 citations 51 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2010Full-Text: http://europepmc.org/articles/PMC3012083Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0015727&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 ItalyPublisher:Springer Science and Business Media LLC Funded by:NIH | Alzheimers Disease Neuroi..., CIHRNIH| Alzheimers Disease Neuroimaging Initiative ,CIHRWasim Khan; Eric Westman; Nigel C. Jones; Lars-Olof Wahlund; Patrizia Mecocci; Bruno Vellas; Magda Tsolaki; Iwona Kłoszewska; Hilkka Soininen; Christian Spenger; Simon Lovestone; J-Sebastian Muehlboeck; Andrew Simmons;Previous studies have shown that hippocampal subfields may be differentially affected by Alzheimer’s disease (AD). This study used an automated analysis technique and two large cohorts to (1) investigate patterns of subfield volume loss in mild cognitive impairment (MCI) and AD, (2) determine the pattern of subfield volume loss due to age, gender, education, APOE ε4 genotype, and neuropsychological test scores, (3) compare combined subfield volumes to hippocampal volume alone at discriminating between AD and healthy controls (HC), and predicting future MCI conversion to AD at 12 months. 1,069 subjects were selected from the AddNeuroMed and Alzheimer’s disease neuroimaging initiative (ADNI) cohorts. Freesurfer was used for automated segmentation of the hippocampus and hippocampal subfields. Orthogonal partial least squares to latent structures (OPLS) was used to train models on AD and HC subjects using one cohort for training and the other for testing and the combined cohort was used to predict MCI conversion. MANCOVA and linear regression analyses showed multiple subfield volumes including Cornu Ammonis 1 (CA1), subiculum and presubiculum were atrophied in AD and MCI and were related to age, gender, education, APOE ε4 genotype, and neuropsychological test scores. For classifying AD from HC, combined subfield volumes achieved comparable classification accuracy (81.7 %) to total hippocampal (80.7 %), subiculum (81.2 %) and presubiculum (80.6 %) volume. For predicting MCI conversion to AD combined subfield volumes and presubiculum volume were more accurate (81.1 %) than total hippocampal volume. (76.7 %).
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4529880Data sources: PubMed CentralBrain Topography; Archivio Istituzionale della Ricerca - Università degli Studi di PerugiaArticle . 2015 . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10548-014-0415-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 69 citations 69 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4529880Data sources: PubMed CentralBrain Topography; Archivio Istituzionale della Ricerca - Università degli Studi di PerugiaArticle . 2015 . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10548-014-0415-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2015 France FrenchPublisher:HAL CCSD Funded by:CIHRCIHRAuthors: Purenne, A.;Purenne, A.;Anaïk Purenne propose dans sa contribution un détour par le Canada, un pays où l’idéal de relations plus symétriques entre la puissance publique et les citoyens a constitué un horizon d’action important pour les mouvements citoyens qui se sont développés dans le sillage de la Révolution tranquille autour de valeurs comme l’égalité de droits, la liberté et la solidarité. Dans les grandes villes du pays, ces aspirations sont aujourd’hui reprises par des mouvements de défense des exclus. Pour ces groupes qui rassemblent des activistes, des « experts » et des exclus, il s’agit de déconstruire l’image de dangerosité associée à certains problèmes ou comportements sociaux tels que l’itinérance, la toxicomanie ou les troubles mentaux (une représentation ordinaire qui, au-delà de sa dimension stigmatisante, ouvre sur la criminalisation de ces personnes) et de promouvoir les droits et la citoyenneté de ces personnes à travers des formes d’action publique davantage co-construites et inclusives. Interrogeant le rôle de ces mouvements dans l’émergence et la diffusion de nouveaux imaginaires sociaux, elle montre que ces luttes produisent des effets bien réels en contribuant en particulier à réorienter les termes du débat public dans le sens d’une moindre stigmatisation. Par la participation de ces groupes de défense à des instances de concertation ou le recours à la désobéissance civile, le nouvel imaginaire parvient aussi dans une certaine mesure à « contaminer » l’action publique et les pratiques professionnelles à travers une myriade de chartes, guidelines, documents de planification, et autres expérimentations mettant en avant l’égalité formelle de droits, sans cependant parvenir à ébranler les fondements structurellement dissymétriques des politiques sécuritaires. International audience
HAL-ENS-LYON; Mémoir... arrow_drop_down HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la Communication; HAL Lumiere Lyon 2; HAL-Lyon 3Part of book or chapter of book . 2015Full-Text: https://hal.science/hal-01280790/documentHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotPart of book or chapter of book . 2015All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______166::19d05ddb0b683375cc51d5ed0f277d49&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la Communication; HAL Lumiere Lyon 2; HAL-Lyon 3Part of book or chapter of book . 2015Full-Text: https://hal.science/hal-01280790/documentHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotPart of book or chapter of book . 2015All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______166::19d05ddb0b683375cc51d5ed0f277d49&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 FrancePublisher:Elsevier BV Funded by:CIHRCIHRPierrick Coupé; José V. Manjón; Elias L. Gedamu; Douglas L. Arnold; Montserrat Robles; D. Louis Collins;pmid: 20417148
International audience; In this paper, a new object-based method to estimate noise in magnitude MR images is proposed. The main advantage of this object-based method is its robustness to background artefacts such as ghosting. The proposed method is based on the adaptation of the Median Absolute Deviation (MAD) estimator in the wavelet domain for Rician noise. The MAD is a robust and efficient estimator initially proposed to estimate Gaussian noise. In this work, the adaptation of MAD operator for Rician noise is performed by using only the wavelet coefficients corresponding to the object and by correcting the estimation with an iterative scheme based on the SNR of the image. During the evaluation, a comparison of the proposed method with several state-of-the-art methods is performed. A quantitative validation on synthetic phantom with and without artefacts is presented. A new validation framework is proposed to perform quantitative validation on real data. The impact of the accuracy of noise estimation on the performance of a denoising filter is also studied. The results obtained on synthetic images show the accuracy and the robustness of the proposed method. Within the validation on real data, the proposed method obtained very competitive results compared to the methods under study.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.media.2010.03.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 205 citations 205 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 3visibility views 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.media.2010.03.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018Embargo end date: 01 Jan 2018 FrancePublisher:arXiv Funded by:CIHR, NIH | Alzheimers Disease Neuroi...CIHR ,NIH| Alzheimers Disease Neuroimaging InitiativeKhvostikov, Alexander; Aderghal, Karim; Krylov, Andrey; Catheline, Gwenaelle; Benois-Pineau, Jenny;In the last decade, computer-aided early diagnostics of Alzheimer's Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission Tomography (PET) and Diffusion Tensor Imaging (DTI) modalities. Furthermore, fusion of imaging modalities in a supervised machine learning framework has shown promising direction of research. In this paper we first review major trends in automatic classification methods such as feature extraction based methods as well as deep learning approaches in medical image analysis applied to the field of Alzheimer's Disease diagnostics. Then we propose our own design of a 3D Inception-based Convolutional Neural Network (CNN) for Alzheimer's Disease diagnostics. The network is designed with an emphasis on the interior resource utilization and uses sMRI and DTI modalities fusion on hippocampal ROI. The comparison with the conventional AlexNet-based network using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (http://adni.loni.usc.edu) demonstrates significantly better performance of the proposed 3D Inception-based CNN. Comment: arXiv admin note: substantial text overlap with arXiv:1801.05968
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2018Data sources: arXiv.org e-Print ArchiveMémoires en Sciences de l'Information et de la CommunicationPreprint . 2018Hyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2018https://doi.org/10.48550/arxiv...Article . 2018License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1809.03972&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2018Data sources: arXiv.org e-Print ArchiveMémoires en Sciences de l'Information et de la CommunicationPreprint . 2018Hyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2018https://doi.org/10.48550/arxiv...Article . 2018License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1809.03972&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, Ireland, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:CIHR, NIH | 1/2 Measuring translation...CIHR ,NIH| 1/2 Measuring translational dynamics and the proteome to identify potential brain biomakers for psychiatric diseaseChristian P. Schaaf; Catalina Betancur; Ryan K. C. Yuen; Jeremy R. Parr; David Skuse; Louise Gallagher; Raphael Bernier; Janet A. Buchanan; Joseph D. Buxbaum; Chun-An Chen; Kira A. Dies; Mayada Elsabbagh; Helen V. Firth; Thomas W. Frazier; Ny Hoang; Jennifer L. Howe; Christian R. Marshall; Jacques L. Michaud; Olivia Rennie; Peter Szatmari; Wendy K. Chung; Patrick Bolton; Edwin H. Cook; Stephen W. Scherer; Jacob A. S. Vorstman;International audience; Autism spectrum disorder (ASD) is often grouped with other brain-related phenotypes into a broader category of neurodevelopmental disorders (NDDs). In clinical practice, providers need to decide which genes to test in individuals with ASD phenotypes, which requires an understanding of the level of evidence for individual NDD genes that supports an association with ASD. Consensus is currently lacking about which NDD genes have sufficient evidence to support a relationship to ASD. Estimates of the number of genes relevant to ASD differ greatly among research groups and clinical sequencing panels, varying from a few to several hundred. This Roadmap discusses important considerations necessary to provide an evidence-based framework for the curation of NDD genes based on the level of information supporting a clinically relevant relationship between a given gene and ASD.
UCL Discovery arrow_drop_down Trinity's Access to Research ArchiveArticle . 2020 . Peer-reviewedData sources: Trinity's Access to Research ArchiveHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41576-020-0231-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 85 citations 85 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UCL Discovery arrow_drop_down Trinity's Access to Research ArchiveArticle . 2020 . Peer-reviewedData sources: Trinity's Access to Research ArchiveHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41576-020-0231-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Springer Science and Business Media LLC Funded by:CIHRCIHRCatharine A. Mielnik; Mary A. Binko; Yuxiao Chen; Adam J. Funk; Emily M. Johansson; Katheron Intson; Nirun Sivananthan; Rehnuma Islam; Marija Milenkovic; Wendy Horsfall; Ruth A. Ross; Laurent Groc; Ali Salahpour; Robert E. McCullumsmith; Shreejoy J. Tripathy; Evelyn K. Lambe; Amy J. Ramsey;AbstractN-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain. Impaired NMDAR signalling through genetic or environmental insults causes a constellation of neurodevelopmental disorders that manifest as intellectual disability, epilepsy, autism, or schizophrenia. It is not clear whether the developmental impacts of NMDAR dysfunction can be overcome by interventions in adulthood. This question is paramount for neurodevelopmental disorders arising from mutations that occur in the GRIN genes, which encode NMDAR subunits, and the broader set of mutations that disrupt NMDAR function. We developed a mouse model where a congenital loss-of-function allele of Grin1 can be restored to wild type by gene editing with Cre recombinase. Rescue of NMDARs in adult mice yields surprisingly robust improvements in cognitive functions, including those that are refractory to treatment with current medications. These results suggest that neurodevelopmental disorders arising from NMDAR deficiency can be effectively treated in adults.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8505246Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-020-00859-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8505246Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-020-00859-4&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2020 United StatesPublisher:Elsevier BV Funded by:CIHRCIHRAuthors: Xia, Frances; Kheirbek, Mazen A.;Xia, Frances; Kheirbek, Mazen A.;Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.
Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.tins.2020.08.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down eScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.tins.2020.08.004&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012 Netherlands, Denmark, France, Spain, Denmark, FrancePublisher:Elsevier BV Funded by:NIH | Alzheimers Disease Neuroi..., CIHR, NIH | UC Davis Alzheimer's Core... +1 projectsNIH| Alzheimers Disease Neuroimaging Initiative ,CIHR ,NIH| UC Davis Alzheimer's Core Center ,NIH| "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies"Eskildsen, S.F.; Coupe, P.; Fonov, V.; Manjon, J.V.; Leung, K.K.; Guizard, N.; Wassef, S.N.; Ostergaard, L.R.; Collins, D.L.; Olde Rikkert, M.; Olde Rikkert, M.; et al, .;Brain extraction is an important step in the analysis of brain images. The variability in brain morphology and the difference in intensity characteristics due to imaging sequences make the development of a general purpose brain extraction algorithm challenging. To address this issue, we propose a new robust method (BEaST) dedicated to produce consistent and accurate brain extraction. This method is based on nonlocal segmentation embedded in a multi-resolution framework. A library of 80 priors is semi-automatically constructed from the NIH-sponsored MRI study of normal brain development, the International Consortium for Brain Mapping, and the Alzheimer's Disease Neuroimaging Initiative databases. In testing, a mean Dice similarity coefficient of 0.9834 ± 0.0053 was obtained when performing leave-one-out cross validation selecting only 20 priors from the library. Validation using the online Segmentation Validation Engine resulted in a top ranking position with a mean Dice coefficient of 0.9781 ± 0.0047. Robustness of BEaST is demonstrated on all baseline ADNI data, resulting in a very low failure rate. The segmentation accuracy of the method is better than two widely used publicly available methods and recent state-of-the-art hybrid approaches. BEaST provides results comparable to a recent label fusion approach, while being 40 times faster and requiring a much smaller library of priors. Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, GlaxoSmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., as well as non-profit partners the Alzheimer's Association and Alzheimer's Drug Discovery Foundation, with participation from the U.S. Food and Drug Administration. Private sector contributions to ADNI are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles. This research was also supported by NIH grants P30AG010129, K01 AG030514, and the Dana Foundation.
Radboud Repository; ... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; METIS Research Information System; NeuroImageArticle . 2012 . Peer-reviewedLicense: Elsevier TDMVBN; Aalborg University Research PortalArticle . 2012VBN; Aalborg University Research PortalArticle . 2012HAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuroimage.2011.09.012&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 388 citations 388 popularity Top 0.1% influence Top 1% impulse Top 1% Powered by BIP!visibility 197visibility views 197 download downloads 1,375 Powered bymore_vert Radboud Repository; ... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; METIS Research Information System; NeuroImageArticle . 2012 . Peer-reviewedLicense: Elsevier TDMVBN; Aalborg University Research PortalArticle . 2012VBN; Aalborg University Research PortalArticle . 2012HAL-Inserm; Hal-DiderotArticle . 2012add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.neuroimage.2011.09.012&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2012 Canada, FrancePublisher:Bentham Science Publishers Ltd. Funded by:CIHRCIHRAuthors: Annweiler, Cédric; Montero-Odasso, Manuel; Muir, S.; Beauchet, Olivier;Annweiler, Cédric; Montero-Odasso, Manuel; Muir, S.; Beauchet, Olivier;International audience; Hypovitaminosis D is associated with cognitive decline in the elderly, but the issue of causality remains unresolved. Definitive evidence would include the visualization of brain lesions resulting from hypovitaminosis D. The aim of the present article is to determine, through a literature review, the location and nature of possible brain disorders in hypovitaminosis D. We found limited brain-imaging data, which reported ischemic infarcts and white matter hyperintensities in hypovitaminosis D, though did not provide their specific location or report any focal atrophy. Based on the finding of executive dysfunctions (i.e., mental shifting and information updating impairments) in the presence of hypovitaminosis D, we suggest that hypovitaminosis D is associated with a dysfunction of the frontal-subcortical neuronal circuits, particularly the dorsolateral circuit. Further imaging studies are required to corroborate this assumption and to determine whether hypovitaminosis D results in degenerative and / or vascular lesions.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3296113Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874440001206010016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 26 citations 26 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2012Full-Text: http://europepmc.org/articles/PMC3296113Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2174/1874440001206010016&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010Publisher:Public Library of Science (PLoS) Funded by:NSERC, CIHRNSERC ,CIHRTaves, Matthew D.; Schmidt, Kim L.; Ruhr, Ilan M.; Kapusta, Katarzyna; Prior, Nora H.; Soma, Kiran K.;The brain and other organs locally synthesize steroids. Local synthesis is suggested when steroid levels are higher in tissue than in the circulation. However, measurement of both circulating and tissue steroid levels are subject to methodological considerations. For example, plasma samples are commonly used to estimate circulating steroid levels in whole blood, but steroid levels in plasma and whole blood could differ. In addition, tissue steroid measurements might be affected by blood contamination, which can be addressed experimentally by using saline perfusion to remove blood. In Study 1, we measured corticosterone and testosterone (T) levels in zebra finch (Taeniopygia guttata) plasma, whole blood, and red blood cells (RBC). We also compared corticosterone in plasma, whole blood, and RBC at baseline and after 60 min restraint stress. In Study 2, we quantified corticosterone, dehydroepiandrosterone (DHEA), T, and 17β-estradiol (E₂) levels in the brains of sham-perfused or saline-perfused subjects. In Study 1, corticosterone and T concentrations were highest in plasma, significantly lower in whole blood, and lowest in RBC. In Study 2, saline perfusion unexpectedly increased corticosterone levels in the rostral telencephalon but not other regions. In contrast, saline perfusion decreased DHEA levels in caudal telencephalon and diencephalon. Saline perfusion also increased E₂ levels in caudal telencephalon. In summary, when comparing local and systemic steroid levels, the inclusion of whole blood samples should prove useful. Moreover, blood contamination has little or no effect on measurement of brain steroid levels, suggesting that saline perfusion is not necessary prior to brain collection. Indeed, saline perfusion itself may elevate and lower steroid concentrations in a rapid, region-specific manner.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2010Full-Text: http://europepmc.org/articles/PMC3012083Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0015727&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 51 citations 51 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2010Full-Text: http://europepmc.org/articles/PMC3012083Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0015727&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2014 ItalyPublisher:Springer Science and Business Media LLC Funded by:NIH | Alzheimers Disease Neuroi..., CIHRNIH| Alzheimers Disease Neuroimaging Initiative ,CIHRWasim Khan; Eric Westman; Nigel C. Jones; Lars-Olof Wahlund; Patrizia Mecocci; Bruno Vellas; Magda Tsolaki; Iwona Kłoszewska; Hilkka Soininen; Christian Spenger; Simon Lovestone; J-Sebastian Muehlboeck; Andrew Simmons;Previous studies have shown that hippocampal subfields may be differentially affected by Alzheimer’s disease (AD). This study used an automated analysis technique and two large cohorts to (1) investigate patterns of subfield volume loss in mild cognitive impairment (MCI) and AD, (2) determine the pattern of subfield volume loss due to age, gender, education, APOE ε4 genotype, and neuropsychological test scores, (3) compare combined subfield volumes to hippocampal volume alone at discriminating between AD and healthy controls (HC), and predicting future MCI conversion to AD at 12 months. 1,069 subjects were selected from the AddNeuroMed and Alzheimer’s disease neuroimaging initiative (ADNI) cohorts. Freesurfer was used for automated segmentation of the hippocampus and hippocampal subfields. Orthogonal partial least squares to latent structures (OPLS) was used to train models on AD and HC subjects using one cohort for training and the other for testing and the combined cohort was used to predict MCI conversion. MANCOVA and linear regression analyses showed multiple subfield volumes including Cornu Ammonis 1 (CA1), subiculum and presubiculum were atrophied in AD and MCI and were related to age, gender, education, APOE ε4 genotype, and neuropsychological test scores. For classifying AD from HC, combined subfield volumes achieved comparable classification accuracy (81.7 %) to total hippocampal (80.7 %), subiculum (81.2 %) and presubiculum (80.6 %) volume. For predicting MCI conversion to AD combined subfield volumes and presubiculum volume were more accurate (81.1 %) than total hippocampal volume. (76.7 %).
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4529880Data sources: PubMed CentralBrain Topography; Archivio Istituzionale della Ricerca - Università degli Studi di PerugiaArticle . 2015 . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10548-014-0415-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 69 citations 69 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2014Full-Text: http://europepmc.org/articles/PMC4529880Data sources: PubMed CentralBrain Topography; Archivio Istituzionale della Ricerca - Università degli Studi di PerugiaArticle . 2015 . 2014 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10548-014-0415-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2015 France FrenchPublisher:HAL CCSD Funded by:CIHRCIHRAuthors: Purenne, A.;Purenne, A.;Anaïk Purenne propose dans sa contribution un détour par le Canada, un pays où l’idéal de relations plus symétriques entre la puissance publique et les citoyens a constitué un horizon d’action important pour les mouvements citoyens qui se sont développés dans le sillage de la Révolution tranquille autour de valeurs comme l’égalité de droits, la liberté et la solidarité. Dans les grandes villes du pays, ces aspirations sont aujourd’hui reprises par des mouvements de défense des exclus. Pour ces groupes qui rassemblent des activistes, des « experts » et des exclus, il s’agit de déconstruire l’image de dangerosité associée à certains problèmes ou comportements sociaux tels que l’itinérance, la toxicomanie ou les troubles mentaux (une représentation ordinaire qui, au-delà de sa dimension stigmatisante, ouvre sur la criminalisation de ces personnes) et de promouvoir les droits et la citoyenneté de ces personnes à travers des formes d’action publique davantage co-construites et inclusives. Interrogeant le rôle de ces mouvements dans l’émergence et la diffusion de nouveaux imaginaires sociaux, elle montre que ces luttes produisent des effets bien réels en contribuant en particulier à réorienter les termes du débat public dans le sens d’une moindre stigmatisation. Par la participation de ces groupes de défense à des instances de concertation ou le recours à la désobéissance civile, le nouvel imaginaire parvient aussi dans une certaine mesure à « contaminer » l’action publique et les pratiques professionnelles à travers une myriade de chartes, guidelines, documents de planification, et autres expérimentations mettant en avant l’égalité formelle de droits, sans cependant parvenir à ébranler les fondements structurellement dissymétriques des politiques sécuritaires. International audience
HAL-ENS-LYON; Mémoir... arrow_drop_down HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la Communication; HAL Lumiere Lyon 2; HAL-Lyon 3Part of book or chapter of book . 2015Full-Text: https://hal.science/hal-01280790/documentHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotPart of book or chapter of book . 2015All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______166::19d05ddb0b683375cc51d5ed0f277d49&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down HAL-ENS-LYON; Mémoires en Sciences de l'Information et de la Communication; HAL Lumiere Lyon 2; HAL-Lyon 3Part of book or chapter of book . 2015Full-Text: https://hal.science/hal-01280790/documentHyper Article en Ligne - Sciences de l'Homme et de la Société; Hal-DiderotPart of book or chapter of book . 2015All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______166::19d05ddb0b683375cc51d5ed0f277d49&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2010 FrancePublisher:Elsevier BV Funded by:CIHRCIHRPierrick Coupé; José V. Manjón; Elias L. Gedamu; Douglas L. Arnold; Montserrat Robles; D. Louis Collins;pmid: 20417148
International audience; In this paper, a new object-based method to estimate noise in magnitude MR images is proposed. The main advantage of this object-based method is its robustness to background artefacts such as ghosting. The proposed method is based on the adaptation of the Median Absolute Deviation (MAD) estimator in the wavelet domain for Rician noise. The MAD is a robust and efficient estimator initially proposed to estimate Gaussian noise. In this work, the adaptation of MAD operator for Rician noise is performed by using only the wavelet coefficients corresponding to the object and by correcting the estimation with an iterative scheme based on the SNR of the image. During the evaluation, a comparison of the proposed method with several state-of-the-art methods is performed. A quantitative validation on synthetic phantom with and without artefacts is presented. A new validation framework is proposed to perform quantitative validation on real data. The impact of the accuracy of noise estimation on the performance of a denoising filter is also studied. The results obtained on synthetic images show the accuracy and the robustness of the proposed method. Within the validation on real data, the proposed method obtained very competitive results compared to the methods under study.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.media.2010.03.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 205 citations 205 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 3visibility views 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.media.2010.03.001&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2018Embargo end date: 01 Jan 2018 FrancePublisher:arXiv Funded by:CIHR, NIH | Alzheimers Disease Neuroi...CIHR ,NIH| Alzheimers Disease Neuroimaging InitiativeKhvostikov, Alexander; Aderghal, Karim; Krylov, Andrey; Catheline, Gwenaelle; Benois-Pineau, Jenny;In the last decade, computer-aided early diagnostics of Alzheimer's Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission Tomography (PET) and Diffusion Tensor Imaging (DTI) modalities. Furthermore, fusion of imaging modalities in a supervised machine learning framework has shown promising direction of research. In this paper we first review major trends in automatic classification methods such as feature extraction based methods as well as deep learning approaches in medical image analysis applied to the field of Alzheimer's Disease diagnostics. Then we propose our own design of a 3D Inception-based Convolutional Neural Network (CNN) for Alzheimer's Disease diagnostics. The network is designed with an emphasis on the interior resource utilization and uses sMRI and DTI modalities fusion on hippocampal ROI. The comparison with the conventional AlexNet-based network using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (http://adni.loni.usc.edu) demonstrates significantly better performance of the proposed 3D Inception-based CNN. Comment: arXiv admin note: substantial text overlap with arXiv:1801.05968
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2018Data sources: arXiv.org e-Print ArchiveMémoires en Sciences de l'Information et de la CommunicationPreprint . 2018Hyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2018https://doi.org/10.48550/arxiv...Article . 2018License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1809.03972&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2018Data sources: arXiv.org e-Print ArchiveMémoires en Sciences de l'Information et de la CommunicationPreprint . 2018Hyper Article en Ligne; Hal-DiderotOther literature type . Preprint . 2018https://doi.org/10.48550/arxiv...Article . 2018License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.48550/arxiv.1809.03972&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, Ireland, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:CIHR, NIH | 1/2 Measuring translation...CIHR ,NIH| 1/2 Measuring translational dynamics and the proteome to identify potential brain biomakers for psychiatric diseaseChristian P. Schaaf; Catalina Betancur; Ryan K. C. Yuen; Jeremy R. Parr; David Skuse; Louise Gallagher; Raphael Bernier; Janet A. Buchanan; Joseph D. Buxbaum; Chun-An Chen; Kira A. Dies; Mayada Elsabbagh; Helen V. Firth; Thomas W. Frazier; Ny Hoang; Jennifer L. Howe; Christian R. Marshall; Jacques L. Michaud; Olivia Rennie; Peter Szatmari; Wendy K. Chung; Patrick Bolton; Edwin H. Cook; Stephen W. Scherer; Jacob A. S. Vorstman;International audience; Autism spectrum disorder (ASD) is often grouped with other brain-related phenotypes into a broader category of neurodevelopmental disorders (NDDs). In clinical practice, providers need to decide which genes to test in individuals with ASD phenotypes, which requires an understanding of the level of evidence for individual NDD genes that supports an association with ASD. Consensus is currently lacking about which NDD genes have sufficient evidence to support a relationship to ASD. Estimates of the number of genes relevant to ASD differ greatly among research groups and clinical sequencing panels, varying from a few to several hundred. This Roadmap discusses important considerations necessary to provide an evidence-based framework for the curation of NDD genes based on the level of information supporting a clinically relevant relationship between a given gene and ASD.
UCL Discovery arrow_drop_down Trinity's Access to Research ArchiveArticle . 2020 . Peer-reviewedData sources: Trinity's Access to Research ArchiveHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41576-020-0231-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 85 citations 85 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UCL Discovery arrow_drop_down Trinity's Access to Research ArchiveArticle . 2020 . Peer-reviewedData sources: Trinity's Access to Research ArchiveHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41576-020-0231-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Publisher:Springer Science and Business Media LLC Funded by:CIHRCIHRCatharine A. Mielnik; Mary A. Binko; Yuxiao Chen; Adam J. Funk; Emily M. Johansson; Katheron Intson; Nirun Sivananthan; Rehnuma Islam; Marija Milenkovic; Wendy Horsfall; Ruth A. Ross; Laurent Groc; Ali Salahpour; Robert E. McCullumsmith; Shreejoy J. Tripathy; Evelyn K. Lambe; Amy J. Ramsey;AbstractN-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain. Impaired NMDAR signalling through genetic or environmental insults causes a constellation of neurodevelopmental disorders that manifest as intellectual disability, epilepsy, autism, or schizophrenia. It is not clear whether the developmental impacts of NMDAR dysfunction can be overcome by interventions in adulthood. This question is paramount for neurodevelopmental disorders arising from mutations that occur in the GRIN genes, which encode NMDAR subunits, and the broader set of mutations that disrupt NMDAR function. We developed a mouse model where a congenital loss-of-function allele of Grin1 can be restored to wild type by gene editing with Cre recombinase. Rescue of NMDARs in adult mice yields surprisingly robust improvements in cognitive functions, including those that are refractory to treatment with current medications. These results suggest that neurodevelopmental disorders arising from NMDAR deficiency can be effectively treated in adults.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8505246Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-020-00859-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC8505246Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41380-020-00859-4&type=result"></script>'); --> </script>
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