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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Nouvel, Fabienne; Lenours, Sébastien; Pillement, Sébastien; Tanguy, Philippe;

    International audience; This book provides an insight on both the challenges and the technological solutions of several approaches, which allow connecting vehicles between each other and with the network. It underlines the trends on networking capabilities and their issues, further focusing on the MAC and Physical layer challenges. Ranging from the advances on radio access technologies to intelligent mechanisms deployed to enhance cooperative communications, cognitive radio and multiple antenna systems have been given particular highlight.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ InTecharrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    InTech
    Part of book or chapter of book . 2011
    Data sources: InTech
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://www.intechopen.com/cit...
    Part of book or chapter of book
    License: CC BY ND SA
    Data sources: UnpayWall
    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Part of book or chapter of book . 2011
    https://doi.org/10.5772/14258...
    Part of book or chapter of book . 2011 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lodewijk J.A. Toonen; Maurice Overzier; Melvin M. Evers; Leticia G. Leon; +10 Authors

    Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein. Expression of mutant ataxin-3 is known to result in transcriptional dysregulation, which can contribute to the cellular toxicity and neurodegeneration. Since the exact causative mechanisms underlying this process have not been fully elucidated, gene expression analyses in brains of transgenic SCA3 mouse models may provide useful insights. Methods Here we characterised the MJD84.2 SCA3 mouse model expressing the mutant human ataxin-3 gene using a multi-omics approach on brain and blood. Gene expression changes in brainstem, cerebellum, striatum and cortex were used to study pathological changes in brain, while blood gene expression and metabolites/lipids levels were examined as potential biomarkers for disease. Results Despite normal motor performance at 17.5 months of age, transcriptional changes in brain tissue of the SCA3 mice were observed. Most transcriptional changes occurred in brainstem and striatum, whilst cerebellum and cortex were only modestly affected. The most significantly altered genes in SCA3 mouse brain were Tmc3, Zfp488, Car2, and Chdh. Based on the transcriptional changes, α-adrenergic and CREB pathways were most consistently altered for combined analysis of the four brain regions. When examining individual brain regions, axon guidance and synaptic transmission pathways were most strongly altered in striatum, whilst brainstem presented with strongest alterations in the pi-3 k cascade and cholesterol biosynthesis pathways. Similar to other neurodegenerative diseases, reduced levels of tryptophan and increased levels of ceramides, di- and triglycerides were observed in SCA3 mouse blood. Conclusions The observed transcriptional changes in SCA3 mouse brain reveal parallels with previous reported neuropathology in patients, but also shows brain region specific effects as well as involvement of adrenergic signalling and CREB pathway changes in SCA3. Importantly, the transcriptional changes occur prior to onset of motor- and coordination deficits. Electronic supplementary material The online version of this article (10.1186/s13024-018-0261-9) contains supplementary material, which is available to authorized users.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2018
    Data sources: PubMed Central
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    NARCIS
    Article . 2018
    Data sources: NARCIS
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    NARCIS
    Article . 2018
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    Article . 2018
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    Radboud Repository
    Article . 2018
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Molecular Neurodegeneration
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    Molecular Neurodegeneration; NARCIS
    Other literature type . Article . 2018 . Peer-reviewed
    License: CC BY
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    ZENODO
    Article . 2018
    License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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      Europe PubMed Central
      Article . 2018
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      Article . 2018
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      Article . 2018
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      Article . 2018
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      Article . 2018
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      Molecular Neurodegeneration
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      Molecular Neurodegeneration; NARCIS
      Other literature type . Article . 2018 . Peer-reviewed
      License: CC BY
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      ZENODO
      Article . 2018
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Christoph Huber-Huber; Julia Steininger; Markus Grüner; Ulrich Ansorge;

    Abstract Visual attention and saccadic eye movements are linked in a tight, yet flexible fashion. In humans, this link is typically studied with dual‐task setups. Participants are instructed to execute a saccade to some target location, while a discrimination target is flashed on a screen before the saccade can be made. Participants are also instructed to report a specific feature of this discrimination target at the trial end. Discrimination performance is usually better if the discrimination target occurred at the same location as the saccade target compared to when it occurred at a different location, which is explained by the mandatory shift of attention to the saccade target location before saccade onset. This pre‐saccadic shift of attention presumably enhances the perception of the discrimination target if it occurred at the same, but not if it occurred at a different location. It is, however, known that a dual‐task setup can alter the primary process under investigation. Here, we directly compared pre‐saccadic attention in single‐task versus dual‐task setups using concurrent electroencephalography (EEG) and eye‐tracking. Our results corroborate the idea of a pre‐saccadic shift of attention. They, however, question that this shift leads to the same‐position discrimination advantage. The relation of saccade and discrimination target position affected the EEG signal only after saccade onset. Our results, thus, favor an alternative explanation based on the role of saccades for the consolidation of sensory and short‐term memory. We conclude that studies with dual‐task setups arrived at a valid conclusion despite not measuring exactly what they intended to measure. In humans, the relation between visual attention and saccadic eye movements is usually studied with psychophysical dual‐task setups. Here, we employ concurrent EEG and eye‐tracking to directly compare dual‐task to single‐task setups and conclude in line with previous research that attention precedes saccades. However, our results suggest that dual‐task setups do not measure what they are supposed to measure, that is, the pre‐saccadic shift of attention.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ NARCISarrow_drop_down
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    NARCIS
    Article . 2021
    Data sources: NARCIS
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Europe PubMed Central
    Article . 2021
    Data sources: PubMed Central
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    Radboud Repository
    Article . 2021
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    Psychophysiology
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      Article . 2021
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      Europe PubMed Central
      Article . 2021
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      Radboud Repository
      Article . 2021
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      Psychophysiology
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    Authors: Ahlenius, H.; Devaraju, K.; Monni, E.; Oki, K.; +12 Authors

    Ischemic stroke causes transient increase of neural stem and progenitor cell (NSPC) proliferation in the subventricular zone (SVZ), and migration of newly formed neuroblasts toward the damaged area where they mature to striatal neurons. The molecular mechanisms regulating this plastic response, probably involved in structural reorganization and functional recovery, are poorly understood. The adaptor protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the brain are poorly understood. Here we demonstrate that LNK is expressed in NSPCs in the adult mouse and human SVZ.Lnk−/−mice exhibited increased NSPC proliferation after stroke, but not in intact brain or following status epilepticus. Deletion ofLnkcaused increased NSPC proliferation while overexpression decreased mitotic activity of these cellsin vitro. We found thatLnkexpression after stroke increased in SVZ through the transcription factors STAT1/3. LNK attenuated insulin-like growth factor 1 signaling by inhibition of AKT phosphorylation, resulting in reduced NSPC proliferation. Our findings identify LNK as a stroke-specific, endogenous negative regulator of NSPC proliferation, and suggest that LNK signaling is a novel mechanism influencing plastic responses in postischemic brain.

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    Journal of Neuroscience
    Article . 2012 . Peer-reviewed
    License: CC BY NC SA
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    MPG.PuRe
    Article . 2012
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    Europe PubMed Central
    Other literature type . 2012
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    Authors: Jérôme Dejeu; Amelie Cot; Patrick Rougeot; Boris Lakard; +2 Authors

    International audience;

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    Authors: Charni, Kadija; Greenan, Nathalie; Besamusca, Janna;

    Dans ce rapport, nous explorons la faisabilité d'une base de données européenne relative aux clauses concernant les conditions de travail dans les conventions collectives des pays de l'UE. Notre proposition s'appuie sur la méthodologie développée par l'Université d'Amsterdam (UvA) et la Fondation WageIndicator pour construire une base de données internationale de conventions collectives et dans les projets BARCOM (VS/2016/0106) et COLBAR Europe (VS/2019/0077) pour collecter et coder les conventions collectives européennes. Il s'appuie également sur le projet CAGE du CNAM-CEET qui a développé une infrastructure de recherche en France pour étudier les résultats des négociations sur l'égalité professionnelle femmes-hommes et le comportement des employeurs. L'idée est de combiner des informations structurées provenant d'une enquête auprès des employeurs avec des informations codées provenant d'une base de données de conventions collectives et des données non structurées provenant d'une archive enregistrant le contenu intégral des textes océrisé des conventions collectives. Une telle infrastructure permettrait une meilleure analyse du processus de négociation, des résultats de la négociation et du comportement des employeurs. En utilisant l'exemple des clauses d'égalité professionelle femmes-hommes, nous démontrons la faisabilité de la construction d'une telle infrastructure et la valeur ajoutée de l'utilisation des informations codées et des méthodes d'exploration de texte pour l'analyse comparative. Deux enquêtes européennes, l'ECS et l'ESES, peuvent être combinées avec la base de données des conventions collectives au niveau individuel et/ou sectoriel. Nous étudions comment les conventions collectives au niveau du secteur et de l'entreprise devraient être collectées pour atteindre une certaine forme de représentativité. In this report, we explore the feasibility of a European database of working conditions clauses in collective agreements in EU countries. Our proposal builds on the methodology developed by the University of Amsterdam (UvA) and the WageIndicator Foundation to build an international database of collective agreements and in the BARCOM (VS/2016/0106) and COLBAR Europe (VS/2019/0077) projects to collect and code European collective agreements. It also builds on the CNAM-CEET CAGE project which has developed a research infrastructure in France to study the outcomes of negotiations on gender professional equality and employer behaviour. The idea is to combine structured information from an employer-level survey with coded information from a database of collective agreements and unstructured data from an archive recording the full content of the OCR processed texts of collective agreements. Such an infrastructure would allow better analysis of the bargaining process, bargaining outcomes and employer behaviour. Using the example of gender equality clauses, we demonstrate the feasibility of building such an infrastructure and the added value of using coded information and text mining methods for comparative analysis. Two European surveys, the ECS and ESES, can be combined with the database of collective agreements at individual and/or sectoral level. We explore how collective agreements at sector and company level should be collected to achieve some form of representativity.

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    Authors: Pousse, Alexandre; Niederman, Laurent; Robutel, Philippe;

    Popular science article associated with the work `On the co-orbital motion in the three-body problem: existence of quasi-periodic horseshoe-shaped orbits" (arXiv:1806.07262) from the same authors. Janus and Epimetheus are two moons of Saturn which exhibit a really peculiar dynamics. As they orbit on circular trajectories whose radii are only 50 km apart (less than their respective diameters), every four (terrestrial) years the bodies are getting closer and their mutual gravitational influence leads to a swapping of the orbits: the outer moon becoming the inner one and vice-versa. In this article, we describe how, from this specific astronomical problem to the KAM theory, we came to prove the existence of perpetually stable trajectories associated with the Janus and Epimetheus orbits. Comment: 16 pages, 7 figures, article de vulgarisation scientifique

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    Authors: Filippo Abbondanza; Philip S. Dale; Carol A. Wang; Marianna E. Hayiou‐Thomas; +29 Authors

    Funding: Royal Society - UF150663, RGF\EA\180141; Wellcome Trust - 217065/Z/19/Z; H2020 European Research Council - 694189; NWO - 451-15-017; National Health and Medical Research Council - 1173896; Canadian Institute for Health Research - MOP-133440. Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions. Publisher PDF Peer reviewed

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    MPG.PuRe
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    St Andrews Research Repository
    Article . 2023 . Peer-reviewed
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    Oxford Brookes University: RADAR
    Other literature type . 2023
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      St Andrews Research Repository
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    Authors: Simonnot, Josephine;

    La plateforme web en ligne pour les archives sonores du CNRS-Musée de l’Homme permet d’accéder à des enregistrements musicaux du monde entier, publiés (disques) et inédit, collectés depuis les années 1900 jusqu’à nos jours. Nous présentons d’abord ces archives sonores gérées par le Centre de recherche en ethnomusicologie. Nous expliquons ensuite leur entrée dans le nouvel écosystème du Web ainsi que leur ouverture à un large public grâce à des outils d’analyse et de visualisation du son. Enfin, nous étudions comment une base de données d’archives sonores peut devenir un outil de collaboration pour produire et la diffuser des connaissances. The online web-based platform for the French CNRS-Musée de l'Homme sound archives offers access to published and unpublished recordings of music from all over the world, collected from the 1900's through the present day. We first introduce these sound archives managed by the Research Centre for Ethnomusicology. We then explain their entry in the new web ecosystem as well as their availability to a broad audience through a suite of tools for analysis and visualization. Finally, we study how a sound archive database can become a collaborative tool for the production and dissemination of knowledge.

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    Authors: Gärtner, Matti; Aust, Sabine; Bajbouj, Malek; Fan, Yan; +8 Authors

    Abstract Converging evidence suggests that a single sub-anesthetic dose of ketamine can produce strong and rapid antidepressant effects in patients that do not respond to standard treatment. Despite a considerable amount of research investigating ketamine's mechanisms of action, the exact neuronal targets conveying the antidepressant effects have not been identified yet. Preclinical studies suggest that molecular changes induced by ketamine bring forward large-scale network reconfigurations that might relate to ketamine's antidepressant properties. In this prospective two-site study we measured resting state fMRI in 24 depressed patients prior to, and 24 h after a single sub-anesthetic dose of ketamine. We analyzed functional connectivity (FC) at baseline and after ketamine and focused our analysis on baseline FC and FC changes directly linked to symptom reduction in order to identify neuronal targets that predict individual clinical responses to ketamine. Our results show that FC increases after ketamine between right lateral prefrontal cortex (PFC) and subgenual anterior cingulate cortex (sgACC) are positively linked to treatment response. Furthermore, low baseline FC between these regions predicts treatment outcome. We conclude that PFC-sgACC connectivity may represent a promising biomarker with both predictive and explanatory power.

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    European Neuropsychopharmacology
    Other literature type . Article . 2019 . Peer-reviewed
    License: Elsevier TDM
    https://doi.org/10.17169/refub...
    Other literature type . 2021
    License: CC BY NC ND
    Data sources: Datacite
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ European Neuropsycho...arrow_drop_down
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      European Neuropsychopharmacology
      Article
      License: CC BY NC ND
      Data sources: UnpayWall
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      European Neuropsychopharmacology
      Other literature type . Article . 2019 . Peer-reviewed
      License: Elsevier TDM
      https://doi.org/10.17169/refub...
      Other literature type . 2021
      License: CC BY NC ND
      Data sources: Datacite
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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