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  • Neuroinformatics
  • Open Access
  • National Institutes of Health

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  • Open Access
    Authors: 
    Jie Xian Dong; Yongam Lee; Michael Kirmiz; Stephanie Palacio; Camelia Dumitras; Claudia M. Moreno; Richard Sando; L. Fernando Santana; Thomas C. Südhof; Belvin Gong; +2 more
    Publisher: eScholarship, University of California
    Country: United States
    Project: NIH | Administrative Supplement... (3U01NS099714-02S1), NIH | Recombinant Immunolabels ... (1U24NS109113-01)

    Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to bind and deliver c...

  • Open Access
    Authors: 
    Sean N Hatton; Khoa H Huynh; Leonardo Bonilha; Eugenio Abela; Saud Alhusaini; Andre Altmann; Marina KM Alvim; Akshara R Balachandra; Emanuele Bartolini; Benjamin Bender; +64 more
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | A global alliance to unlo... (1R01MH117601-01), NIH | Multimodal imaging of cog... (2R01NS065838-06A1), UKRI | Imaging prognostic marker... (MR/K023152/1), NIH | ENIGMA World Aging Center (1R56AG058854-01), UKRI | Translation of novel imag... (G0802012), NIH | ENIGMA Center for Worldwi... (3U54EB020403-04S1), CIHR , NSERC , NIH | High resolution mapping o... (1R01AG059874-01), NHMRC | Human Epilepsy: Understan... (1091593),...

    AbstractThe epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, i...

  • Open Access English
    Authors: 
    Jacqueline R. Meadows; Chevonne Parker; Kathleen M. Gilbert; Sarah J. Blossom; Jamie C. DeWitt;
    Publisher: Taylor & Francis Group
    Project: NIH | CD4+ T cell-mediated neur... (5K02ES024387-03), NIH | Developmental programming... (4R01ES021484-04)

    Trichloroethylene (TCE) is a widespread environmental contaminant associated with developmental immunotoxicity and neurotoxicity. Previous studies have shown that MRL+/+ mice exposed to TCE from gestation through early-life demonstrate robust increases in inflammatory m...

  • Open Access
    Authors: 
    Alan R. Mardinly; Ian A. Oldenburg; Nicolas C. Pégard; Savitha Sridharan; Evan H Lyall; Kirill Chesnov; Stephen G. Brohawn; Laura Waller; Hillel Adesnik;
    Publisher: eScholarship, University of California
    Country: United States
    Project: NIH | New Optical Strategies to... (3DP2NS087725-01S1), NIH | CORE Grant for Vision Res... (5P30EY003176-29), NIH | Holographic control of ne... (5F32NS095690-03)

    Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a new multiphoton holographic approach to activate or suppress the activity of ensembles of cortical neuro...

  • Publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors: 
    Ozan Ozdenizci; Ye Wang; Toshiaki Koike-Akino; Deniz Erdogmus;
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Project: NSF | CPS: TTP Option: Synergy:... (1544895), NSF | CAREER: Signal Models, Ch... (1149570), NIH | Translational refinement ... (3R01DC009834-04S1)

    Deep learning methods for person identification based on electroencephalographic (EEG) brain activity encounters the problem of exploiting the temporally correlated structures or recording session specific variability within EEG. Furthermore, recent methods have mostly ...

  • Open Access
    Authors: 
    Anthony G. Hudetz; Colin Humphries; Jeffrey R. Binder;
    Publisher: Frontiers Media SA
    Project: NIH | Neuroimaging of Anestheti... (1R01GM103894-01A1), NIH | General Anesthetics and C... (5R01GM056398-16)

    Patterns of resting state connectivity change dynamically and may represent modes of cognitive information processing. The diversity of connectivity patterns (global brain states) reflects the information capacity of the brain and determines the state of consciousness. ...

  • Open Access English
    Authors: 
    Eun Young eKim; Hans J Johnson; Hans J Johnson;
    Publisher: Frontiers Media SA
    Project: NIH | Connectity analysis tools... (5U54EB005149-05), NIH | Enterprise Storage In A C... (1S10RR023392-01)

    A robust multi-modal tool, for automated registration, bias correction, and tissue classification, has been implemented for large-scale heterogeneous multi-site longitudinal MR data analysis.This work focused on improving the an iterative optimization framework between ...

  • Open Access English
    Authors: 
    Susan Mosher Ruiz; Marlene Oscar-Berman;
    Project: NIH | Affective and Conative Ch... (5K05AA000219-14), NIH | AFFECTIVE AND CONATIVE CH... (5R01AA007112-05)

    As the number of women who use alcohol increases, so does the number of women who engage in alcohol abuse and develop alcohol dependence. The recent increased focus on women and gender differences in alcoholism research has largely come about following recognition that ...

  • Open Access
    Authors: 
    Mark D. Shen; Joseph Piven;
    Project: NIH | MEG Studies of Auditory P... (1U54HD086984-01), NIH | UNC BIRCWH Career Develop... (5K12HD001441-07), NIH | A Longitudinal MRI Study ... (2R01HD055741-06), NIH | Postdoctoral Research in ... (5T32HD040127-05), NIH | A Longitudinal MRI Study ... (1R01HD059854-01A1)

    Autism spectrum disorder (ASD) is a heterogeneous condition that affects 1 in 68 children. Diagnosis is based on the presence of characteristic behavioral impairments that emerge in the second year of life and thus is not typically made until 3 to 4 years of age. Recent...

  • Open Access English
    Authors: 
    Nicholas L. Balderston; Douglas H. Schultz; Sylvain Baillet; Fred J. Helmstetter;
    Publisher: Public Library of Science
    Project: NIH | Distributed synaptic plas... (5R01MH069558-04)

    The role of consciousness in learning has been debated for nearly 50 years. Recent studies suggest that conscious awareness is needed to bridge the gap when learning about two events that are separated in time, as is true for trace fear conditioning. This has been repea...