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  • Neuroinformatics
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lillehaug, Sveinung; Yetman, Michael J.; Puchades, Maja A.; Checinska, Martyna M.; +4 Authors

    Tabular overview (csv format) of brain-wide reporter expression mapped in five commonly used tetracycline-transactivator (tTA) driver lines: neuropsin (Nop); L7/Purkinje cell protein 2 (Pcp2); Pituitary homeobox 3 (Pitx3); cellular prion protein (Prnp), and Ca2+/calmodulin-dependent protein kinase IIa (Camk2a). This analysis is derived from microscopic brain images taken from 12 driver-reporter constructs (DOIs for source data sets are specified in data descriptor file listed below; hbp-00170\_Comparative\_DataDescriptor\_v1p1.txt) in which the different promoters regulate the expression of the E. coli derived LacZ reporter gene encoding β-galactosidase, visualized histologically using X-gal (5-Bromo-4-chloro-3-indolyl β-d-galactopyranoside) as a substrate. Labelling was observed in microscopic images that were spatially registered to the Allen Mouse Common Coordinate Framework (v2; mouse.brain-map.org). The density of labeling was assessed by two independent researchers using a semi-quantitative grading system from 0 – 4, introduced in Yetman et al., Brain Struct Funct 221:2231-49, 2016. Here grade 0 represents absence of labeled cells (less than 1 per 0.01 mm2), grade 1 - low density (few cells, possible to count), grade 2 - medium density (several cells that can be individually discerned, but not readily counted), grade 3 - high density (many labeled cells with large degree of overlap), and grade 4 - very high density (where individual cells cannot be discerned). For each promoter-tTA line one representative case was semi-quantitatively scored and results verified in the other cases. Scores did not vary more than 1 grade between cases or researchers in any regions. The highest numbers were reported. If the density of labeling was found to vary substantially within a region, the highest observed score was recorded.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.25493/arks-...
    Dataset . 2018
    License: CC BY
    Data sources: Datacite; Sygma
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://doi.org/10.25493/arks-...
      Dataset . 2018
      License: CC BY
      Data sources: Datacite; Sygma
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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search
The following results are related to Neuroinformatics. Are you interested to view more results? Visit OpenAIRE - Explore.
1 Research products
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lillehaug, Sveinung; Yetman, Michael J.; Puchades, Maja A.; Checinska, Martyna M.; +4 Authors

    Tabular overview (csv format) of brain-wide reporter expression mapped in five commonly used tetracycline-transactivator (tTA) driver lines: neuropsin (Nop); L7/Purkinje cell protein 2 (Pcp2); Pituitary homeobox 3 (Pitx3); cellular prion protein (Prnp), and Ca2+/calmodulin-dependent protein kinase IIa (Camk2a). This analysis is derived from microscopic brain images taken from 12 driver-reporter constructs (DOIs for source data sets are specified in data descriptor file listed below; hbp-00170\_Comparative\_DataDescriptor\_v1p1.txt) in which the different promoters regulate the expression of the E. coli derived LacZ reporter gene encoding β-galactosidase, visualized histologically using X-gal (5-Bromo-4-chloro-3-indolyl β-d-galactopyranoside) as a substrate. Labelling was observed in microscopic images that were spatially registered to the Allen Mouse Common Coordinate Framework (v2; mouse.brain-map.org). The density of labeling was assessed by two independent researchers using a semi-quantitative grading system from 0 – 4, introduced in Yetman et al., Brain Struct Funct 221:2231-49, 2016. Here grade 0 represents absence of labeled cells (less than 1 per 0.01 mm2), grade 1 - low density (few cells, possible to count), grade 2 - medium density (several cells that can be individually discerned, but not readily counted), grade 3 - high density (many labeled cells with large degree of overlap), and grade 4 - very high density (where individual cells cannot be discerned). For each promoter-tTA line one representative case was semi-quantitatively scored and results verified in the other cases. Scores did not vary more than 1 grade between cases or researchers in any regions. The highest numbers were reported. If the density of labeling was found to vary substantially within a region, the highest observed score was recorded.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    https://doi.org/10.25493/arks-...
    Dataset . 2018
    License: CC BY
    Data sources: Datacite; Sygma
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    1
    citations1
    popularityAverage
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ https://doi.org/10.2...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      https://doi.org/10.25493/arks-...
      Dataset . 2018
      License: CC BY
      Data sources: Datacite; Sygma
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
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