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4,167 Research products, page 1 of 417

  • Neuroinformatics
  • Open Access
  • eScholarship - University of California

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  • Open Access
    Authors: 
    Jie Xian Dong; Yongam Lee; Michael Kirmiz; Stephanie Palacio; Camelia Dumitras; Claudia M. Moreno; Richard Sando; L. Fernando Santana; Thomas C. Südhof; Belvin Gong; +2 more
    Publisher: eScholarship, University of California
    Country: United States
    Project: NIH | Administrative Supplement... (3U01NS099714-02S1), NIH | Recombinant Immunolabels ... (1U24NS109113-01)

    Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to bind and deliver c...

  • Open Access English
    Authors: 
    Zdeňa A. Op de Macks; Silvia A. Bunge; Orly N. Bell; Linda Wilbrecht; Lance J. Kriegsfeld; Andrew S. Kayser; Ronald E. Dahl;
    Publisher: eScholarship, University of California
    Country: United States
    Project: WT

    © 2016 The Authors Adolescence is a developmental period characterized by a greater tendency to take risks. While the adult literature has shown that sex steroids influence reward-related brain functioning and risk taking, research on the role of these hormones during p...

  • Open Access
    Authors: 
    Alan R. Mardinly; Ian A. Oldenburg; Nicolas C. Pégard; Savitha Sridharan; Evan H Lyall; Kirill Chesnov; Stephen G. Brohawn; Laura Waller; Hillel Adesnik;
    Publisher: eScholarship, University of California
    Country: United States
    Project: NIH | New Optical Strategies to... (3DP2NS087725-01S1), NIH | CORE Grant for Vision Res... (5P30EY003176-29), NIH | Holographic control of ne... (5F32NS095690-03)

    Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a new multiphoton holographic approach to activate or suppress the activity of ensembles of cortical neuro...

  • Open Access English
    Authors: 
    Karen Krukowski; Austin Chou; Xi Feng; Brice Tiret; Maria-Serena Paladini; Lara-Kirstie Riparip; Myriam M. Chaumeil; Cynthia A. Lemere; Susanna Rosi;
    Publisher: MDPI AG
    Country: United States
    Project: NIH | In vivo metabolic imaging... (1R21NS096718-01), NIH | Impact of aging on immune... (5F32AG054126-02), NIH | UCSF-GIVI Center for AIDS... (3P30AI027763-12S2), NIH | Effects of traumatic brai... (5R21AG042016-02), NIH | Aging exacerbates trauma-... (5R01AG056770-02), NIH | Generation of a Complemen... (1R21AG044713-01A1)

    synapse interactions. Specifically, we found significant accumulation of C1q on synapses within the hippocampus, which was paralleled by synapse loss 30 days post injury. We used genetic and pharmacological approaches to determine the mechanistic role of complement init...

  • Open Access
    Authors: 
    Rutvik V Shah; Gillian Grennan; Mariam Zafar-Khan; Fahad Alim; Sujit Dey; Dhakshin S. Ramanathan; Jyoti Mishra;
    Publisher: eScholarship, University of California
    Country: United States

    AbstractDepression is a multifaceted illness with large interindividual variability in clinical response to treatment. In the era of digital medicine and precision therapeutics, new personalized treatment approaches are warranted for depression. Here, we use a combinati...

  • Open Access
    Authors: 
    Sophie L. Wilcox; Sylvia M. Gustin; Paul M. Macey; Christopher C. Peck; Greg M. Murray; Luke A. Henderson;
    Publisher: Society for Neuroscience
    Countries: Belgium, United States

    © 2015 the authors. Accumulated evidence from experimental animal models suggests that neuronal loss within the dorsal horn is involved in the development and/or maintenance of peripheral neuropathic pain. However, to date, no study has specifically investigated whether...

  • Open Access English
    Authors: 
    Samantha J Richerson; Mark Ingram; Danielle Perry; Mark M. Stecker;
    Publisher: BioMed Central
    Country: United States

    Abstract Background Classifying the types of extracellular potentials recorded when neural structures are activated is an important component in understanding nerve pathophysiology. Varying definitions and approaches to understanding the factors that influence the pote...

  • Open Access
    Authors: 
    Nandipati, Sirisha; Litvan, Irene;
    Publisher: eScholarship, University of California
    Country: United States

    Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown, but several env...

  • Open Access English
    Authors: 
    Delanty, Norman; Fisher, Simon E; Byerley, William F.; Wendland, Jens R; Craddock, Nick; Ferrucci, Luigi; Fanous, Ayman H; Mather, Karen A.; Li, Miaoxin; Martin, Nicholas G.; +261 more
    Countries: Netherlands, Netherlands, Finland, France, Finland, United States, United Kingdom, Australia, United Kingdom, Netherlands ...
    Project: EC | ePerMed (692145)

    Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging ph...

  • Open Access
    Authors: 
    Swaminathan, Shanker; Shen, Li; Risacher, Shannon L; Yoder, Karmen K; West, John D; Kim, Sungeun; Nho, Kwangsik; Foroud, Tatiana; Inlow, Mark; Potkin, Steven G; +9 more
    Publisher: eScholarship, University of California
    Country: United States

    Amyloid imaging with [(11)C]Pittsburgh Compound-B (PiB) provides in vivo data on plaque deposition in those with, or at risk for, Alzheimer's disease (AD). We performed a gene-based association analysis of 15 quality-controlled amyloid-pathway associated candidate genes...