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157,729 Research products

  • Neuroinformatics
  • 2019-2023
  • Open Access

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Lukas Preis; Arda Can Cetindag; Kersten Villringer; Jochen B. Fiebach; +1 Authors

    AbstractBackgroundThe importance of vascular integrity in the context of neurodegeneration and specifically Alzheimer’s disease (AD) is increasingly recognized. It has been shown that Blood‐brain barrier (BBB) breakdown in the hippocampus correlates with functional impairment independent of AD pathology. The aim of this study is to investigate BBB permeability in early stages of the AD continuum including subjective cognitive decline (SCD).MethodStudy participants were characterized according to the appropriate research criteria and categorized as normal controls (NC), individuals with SCD and mild cognitive impairment due to AD (MCI‐AD). Besides a clinical and neuropsychological assessment, the participants underwent structural magnet resonance imaging (MRI), ApoE genotyping and lumbar puncture. AD pathology was examined in accordance to the ATN‐system. Dynamic contrast‐enhanced (DCE) MRI T1 mapping and Patlak analysis using Rocketship software were employed to assess BBB permeability changes.ResultSeventy‐one participants were included (NC = 18, SCD = 36, MCI‐AD = 17). The average age of the cohort was 75 years and the sample consisted of 41% females. The median MMSE scores were 30 for NC and SCD and 27 for the MCI‐AD group. Amyloid pathology, measured in the CSF, was detected in 11% of the NC group (n = 2), 58 % of SCD (n = 21) and 29% of MCI/AD (n = 5). Bilateral BBB dysfunction was identified in 44% of NC (n = 8), in 31% of SCD (n = 11) and 24% of MCI‐AD (n = 4), additionally unilateral BBB dysfunction has been identified in 22% of NC (n = 4), 25% of SCD (n = 9) and 41% of MCI‐AD (n = 7).ConclusionBy using DCE MRI T1 mapping a surprisingly high proportion of increased BBB permeability in the hippocampus can be detected across all groups. Detailed analyzes will reveal the impact of BBB permeability on cognitive function in SCD.

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    Alzheimer s & Dementia
    Article . 2020 . Peer-reviewed
    License: Wiley Online Library User Agreement
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Alzheimer s & Dement...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Alzheimer s & Dementia
      Article . 2020 . Peer-reviewed
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    Authors: Quoc Khai Le; Thi Huong Trang Pham; Trung Hieu Nguyen; Thi Diem Thy Huynh; +1 Authors

    Sleep deprivation of high school and university students is currently an actual concerning issue. Sleep deprivation is one of the leading causes of dozing-off during daytime. Usually, the state of drowsiness is very little concerned, but studies on drowsiness show the importance of investigating the frequency of occurrence as well as the need to clarify the cause and propose limited measures appeared dozing-off. Dozing-off is not only an undesirable state and disrupts daily activities, but also provides information on personal health status. In that case, early alertness for dozing-off event is very helpful in preventing unwanted consequences. The study has designed a process to record dozing-off event, then constructed and implemented the hypnogram processing program that evaluated quantitative changes in polysomnography signals at sleep onset, the transition time from wake stage to sleep stage. By analyzing the energy spectrum of the signal and using wavelet transform in combine with the support vector machine algorithm, the research allows a comprehensive evaluation of the state of dozing-off. Determining the exact time of onset of sleep is very important in the study of drowsiness. Extracting the time of this event appears to help develop an application for early warning dozing-off. Besides, it allows making an initial assessment of the condition of the subject when the time of drowsiness begins suddenly. Six recordings from volunteered students were processed from a 45-minute vigilance test. All of the volunteers had no neuropathy and were well explained to the procedures used in this study. The results show that depending on kinds of different applications, signals such as EEG, EOG, or EMG are used individually or in combination to fetch suitable results. The result presented a successful method to distinguish dozing-off event with other stages.

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    Science & Technology Development Journal - Engineering and Technology
    Article . 2020 . Peer-reviewed
    License: CC BY
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      Science & Technology Development Journal - Engineering and Technology
      Article . 2020 . Peer-reviewed
      License: CC BY
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    Authors: Génevaux, Jean-Michel;
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    Hyper Article en Ligne
    Other literature type . 2020
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      Other literature type . 2020
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    Authors: Taylor, JSH; Davis, Matthew H; Rastle, Kathleen;

    Reading involves transforming arbitrary visual symbols into sounds and meanings. This study interrogated the neural representations in ventral occipitotemporal cortex (vOT) that support this transformation process. Twenty-four adults learned to read 2 sets of 24 novel words that shared phonemes and semantic categories but were written in different artificial orthographies. Following 2 wk of training, participants read the trained words while neural activity was measured with functional MRI. Representational similarity analysis on item pairs from the same orthography revealed that right vOT and posterior regions of left vOT were sensitive to basic visual similarity. Left vOT encoded letter identity and representations became more invariant to position along a posterior-to-anterior hierarchy. Item pairs that shared sounds or meanings, but were written in different orthographies with no letters in common, evoked similar neural patterns in anterior left vOT. These results reveal a hierarchical, posterior-to-anterior gradient in vOT, in which representations of letters become increasingly invariant to position and are transformed to convey spoken language information. Significance Learning to read is the most important milestone in a child’s education. However, controversies remain regarding how readers’ brains transform written words into sounds and meanings. We address these by combining artificial language learning with neuroimaging to reveal how the brain represents written words. Participants learned to read new words written in 2 different alphabets. Following 2 wk of training, we found a hierarchy of brain areas that support reading. Letter position is represented more flexibly from lower to higher visual regions. Furthermore, higher visual regions encode information about word sounds and meanings. These findings advance our understanding of how the brain comprehends language from arbitrary visual symbols.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2019
    Data sources: PubMed Central
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    Apollo
    Article . 2020
    License: CC BY
    Data sources: Datacite
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    Apollo
    Other literature type . 2019
    License: CC BY
    Data sources: Apollo
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    Proceedings of the National Academy of Sciences
    Article . 2019 . Peer-reviewed
    License: CC BY
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      Europe PubMed Central
      Article . 2019
      Data sources: PubMed Central
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      Apollo
      Article . 2020
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      Apollo
      Other literature type . 2019
      License: CC BY
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      Proceedings of the National Academy of Sciences
      Article . 2019 . Peer-reviewed
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Cantor, David;

    While the world is aware of Covid’s devastating effect on the world’s health and economy worldwide, this event has highlighted the need to understand how viruses and other micro infectious events enter and effect the brain contributing to changes in function and behavior. Given that this and other viruses do indeed enter the brain, studies are now being turned to understand possible residual effects on behavior and brain function. More than ever, the need to understand how such infiltration leads to demyelinating and general neuroinflammatory processes and this has been noted effecting frontal lobes and brainstem structures. Initial structural neuroimaging studies have evidenced generalized encephalopathies and damage particularly to medial temporal regions. Studies showing that as much as six months following discharge from hospitalization, there are reports that over 30% of patients are experiencing decline in cognitive functioning and over 20% of patients experience significant mood regulation problems. Functional neuroimaging studies have corroborated structural findings in noting dysfunction as expected changes in the frontal regions. EEG studies have also noted frontal regions with increased delta corresponding to these findings. COVID-19 patients with resultant seizures, focal areas have been identified in the temporal, frontotemporal, and central-parietal regions. This presentation will summarize initial efforts to review a clinical sample of qEEG correlates resulting from COVID infection including sLORETA analyses that can help to understand the scaled vulnerability for certain areas of the brain for such infections and shed more light on why certain qEEG features are likely to be expected in the presence of underlying neuroinflammatory mechanisms. Preliminary cases studies with patients post COVID-19 exposure as well as non-exposed neurotypical cases experiencing the neuroinflammatory effects of the COVID vaccination will be presented and reviewed. These cases will illustrate the emerging findings that evidence increased delta and theta absolute power in bilateral frontal poles, fronto-temporal regions and central-parietal regions and increased volumetric deviations in the frontal and temporal regions by sLORETA analyses with concomitant changes in aspects of cognition and mood regulation. Current vaccines being used to prevent more serious effects of the COVID-19 and potential variants can stimulant the immune system to trigger similar cytokine storms in some individuals and can trigger neuroinflammatory effects on the brain. qEEG may have the ability to provide biomarkers for individuals who may have cytokine storms by any of number of challenges to the immune system.

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    International Journal of Psychophysiology
    Article . 2021 . Peer-reviewed
    License: Elsevier TDM
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      International Journal of Psychophysiology
      Article . 2021 . Peer-reviewed
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    Authors: Yoona, Kang; Jeesung, Ahn; Danielle, Cosme; Laetitia, Mwilambwe-Tshilobo; +10 Authors

    AbstractEvidence on the harms and benefits of social media use is mixed, in part because the effects of social media on well-being depend on a variety of individual difference moderators. Here, we explored potential neural moderators of the link between time spent on social media and subsequent negative affect. We specifically focused on the strength of correlation among brain regions within the frontoparietal system, previously associated with the top-down cognitive control of attention and emotion. Participants (N = 54) underwent a resting state functional magnetic resonance imaging scan. Participants then completed 28 days of ecological momentary assessment and answered questions about social media use and negative affect, twice a day. Participants who spent more than their typical amount of time on social media since the previous time point reported feeling more negative at the present moment. This within-person temporal association between social media use and negative affect was mainly driven by individuals with lower resting state functional connectivity within the frontoparietal system. By contrast, time spent on social media did not predict subsequent affect for individuals with higher frontoparietal functional connectivity. Our results highlight the moderating role of individual functional neural connectivity in the relationship between social media and affect.

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    Scientific Reports
    Article . 2023 . Peer-reviewed
    License: CC BY
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      Scientific Reports
      Article . 2023 . Peer-reviewed
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    Authors: Medrano-Jiménez, Elisa; Itzia Jiménez-Ferrer Carrillo; Pedraza-Escalona, Martha; Ramírez-Serrano, Cristina; +8 Authors

    Figure S3. Oleanolic acid and scopoletin inhibit LPS-induced NF-kB activity in mouse RAW-Blue macrophages. (PDF 283 kb)

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    Authors: Delmas, Renaud;

    La gestion des environnements dynamiques à risques (transports, nucléaire, médecine etc.) progresse tous les jours dans notre société. Leur bonne gestion requiert une fiabilisation des systèmes techniques et organisationnels et nécessite de renforcer de la formation des opérateurs aux compétences non techniques. Notre thèse s’intéresse à ce dernier axe. Dans la littérature, le concept de compétences non techniques reste flou.Ce mémoire propose d’examiner ce concept, au travers de l’étude des situations de formation des leaders médicaux du Service de Santé des Armées (SSA) à la prise en charge d’afflux massif de victimes en médecine de l’avant. On adoptera le point de vue des formateurs, lorsque ceux-ci analysent l’activité des leadeurs.Dans une première partie (Chap. I,II et III), nous décrivons la formation des médecins du SSA, les enjeux et outils actuels de la formation à la prise en charge d’afflux massif de victimes et aux compétences non techniques, ainsi que le rôle qu’y jouent les formateurs. La partie théorique recense les travaux portant sur le concept de compétences non techniques, de son origine à sa diffusion dans divers domaines d’activité (Chap. IV, V). Nous décrivons les actuelles taxonomies NTS, dont la majorité est structurée en sept catégories NTS : leadership, travail d’équipe, communication, conscience de la situation, prise de décision, gestion de la fatigue et gestion du stress. Nous caractérisons l’activité des leaders médicaux (chap.VI.) puis positionnons le concept de compétences non techniques dans le domaine de l’ergonomie et de la didactique professionnelle (Chap. VII).La partie empirique débute par la construction d’un corpus recensant toutes les habiletés sous-jacentes à la performance du leader médical sur la base d’entretien d’alloconfrontation avec des formateurs du SSA (Chap. IX). Ce corpus est ensuite classé par les dix formateurs en trois classes : technique (T), non technique (NT), technique et non technique (T-NT).La première étude (Chap. X) analyse de la classification des formateurs, elle révèle l’importance de la classe NT, ainsi que l'existence de cinq styles représentationnels adoptés par les formateurs. La seconde étude (Chapitre XI) examine le sens conféré par les formateurs aux habiletés et souligne des écarts au sein même des styles représentationnels. Nous identifions cinq familles d’habiletés, avec une domination des familles dites faiblement-divergente (45%) et NT (41%). On constate que les formateurs ont identifié unanimement 30 habiletés comme étant non techniques qu'on appellera les habiletés NT-ONLY.Les études suivantes (Chap.XII et XIII) ont reposé sur le classement des 30 habiletés NT-ONLY par 21 formateurs CRM et 13 formateurs MED. La troisième étude (Chap. XII) a mis en évidence que tous les formateurs attribuent plus d’une catégorie par habileté. Ceci démontre que les catégories NTS ne sont pas exclusives. Par ordre décroissant, le leadership, la communication, le travail d’équipe et la conscience de la situation ont été les plus utilisées par les formateurs, sans différences intergroupes. Le groupe CRM a plus utilisé la catégorie de prise de décision, le groupe MED a favorisé la gestion du stress et de la fatigue. La quatrième étude (Chap. XIII) a examiné la possibilité de regrouper certaines des sept catégories NTS sur la base du classement des habiletés NT-ONLY. Nos résultats ont mis en évidence des proximités entre les catégories de leadership, travail d’équipe et communication, puis entre celles de conscience de la situation et prise de décision, et enfin entre celles de gestion de la fatigue et de gestion du stress. La dernière partie de cette thèse (Chap. XIV) discute de la méthodologie mise en place, des résultats obtenus et des questions qu’ils soulèvent. The high-risk dynamic environments management (transports, nuclear industry, medicine etc.) increases every day in our societies. A good management of these environments requires the reliability of technical and organization systems. It also requires the training of operators in non-technical skills. This thesis is focused on this last point. In the literature, the non-technical skills concept stays unclear.This works examines this concept, based on the training situations of medical leaders from the Army Health Service to wounded people massive influx in theatre operation. We adopt the point of view from trainers when they are analyzing activity of leaders.In a first part (Chap. I, II & III), we describe the training of the French army physicians and the current stakes and tools of the wounded people massive influx management training. This part also describes current non-technical skills training and trainer roles. The theoretical part describes works around non-technical skills, from its origins to its diffusion in various areas (Chap. IV & V). We describe the current NTS taxonomies which are mainly based on a divided into seven NTS categories: leadership, teamworking, communication, situation awareness, decision making, coping with fatigue and managing stress. Then, we characterize the activity of medical leader (Chap. VI). This theoretical part lead us to consider non-technical skills as technical or non-technical abilities (Chap. VII) and is conclude with the formulation of our research questions (Chap. VIII).The empirical part of this thesis starts with the elaboration of a corpus (Chap. IX) listing all the abilities linked to the leader performance. The construction of this corpus is based on twenty individual alloconfrontation interviews conducted with physician-trainers. Ten of them classified the abilities into three classes: technical (T), non-technical (NT), technical and non-technical (T-NT).The first study (Chap. X) analyses trainer classification. It shows the importance of NT class and identify the existence of five “representational styles” among trainers. The second study (Chap. XI) examines the meaning assigned by each participant to ability and highlight gaps between trainer representations. Then we identified five ability families with a two main families: slightly-divergent (45%) and NT (41%). We notice that there is a core of thirty abilities which are unanimously classified as non-technical only.The following studies (Chap. XII and XIII) are based on the classification of the 30 NT-only abilities by CRM trainers and MED trainers. The third study highlight that all trainers associate more than once NTS category to each ability. That shows NTS categories are not exclusive. In a descendant order leadership, communication, teamworking and situation awareness are the most used by trainers without difference between groups. The CRM group used more the leadership category. The MED group used more stress managing and coping with fatigue. The fourth study examines if it possible to gather, even to merge, some NTS categories based on the classification of NT-ONLY abilities. Our results show the proximities between the categories of leadership, teamwork and communication, then between situation awareness and decision making, and finally between managing stress and coping with stress. The last part of this thesis (Chap. XIV) discuss about the methodology used, results and questions they raise.

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    Authors: Belle Collaboration; Abdesselam, A.; Adachi, I.; Adamczyk, K.; +196 Authors

    We report the first measurement of the $D^{\ast -}$ meson polarization in the decay $B^0 \to D^{*-} \tau^+\nu_{\tau}$ using the full data sample of 772$\times 10^6$ $B\bar{B}$ pairs recorded with the Belle detector at the KEKB electron-positron collider. Our result, $F_L^{D^\ast} = 0.60 \pm 0.08 ({\rm stat}) \pm 0.04 ({\rm sys})$, where $F_L^{D^\ast}$ denotes the $D^{\ast-}$ meson longitudinal polarization fraction, agrees within about $1.7$ standard deviations of the standard model prediction. Comment: 16 pages, 4 figures, CKM 2018

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    Authors: Salimi, Fatemeh;

    While the reference framework for international portfolio choice emphasizes a mean-variance framework, uncovered parity conditions only involve mean stock or bond returns. We propose to augment the empirical specification by using the relative stock market uncertainty of two countries as an extra determinant of their bilateral exchange rate returns. A rise in the relative uncertainty of one stock market will lead capital to flow to the other stock market and generate an appreciation in the currency of the latter. By focusing on the JPY/USD exchange rate returns during the most recent decade (2009-2019) and relying on a nonlinear framework, we provide evidence that the Japanese-US differential stock market uncertainty affects the JPY/USD returns both contemporaneously and with weekly lags. This finding is robust when we control for the stock returns differential and the differential changes in Japanese and US unconventional monetary policy measures.

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    Authors: Lukas Preis; Arda Can Cetindag; Kersten Villringer; Jochen B. Fiebach; +1 Authors

    AbstractBackgroundThe importance of vascular integrity in the context of neurodegeneration and specifically Alzheimer’s disease (AD) is increasingly recognized. It has been shown that Blood‐brain barrier (BBB) breakdown in the hippocampus correlates with functional impairment independent of AD pathology. The aim of this study is to investigate BBB permeability in early stages of the AD continuum including subjective cognitive decline (SCD).MethodStudy participants were characterized according to the appropriate research criteria and categorized as normal controls (NC), individuals with SCD and mild cognitive impairment due to AD (MCI‐AD). Besides a clinical and neuropsychological assessment, the participants underwent structural magnet resonance imaging (MRI), ApoE genotyping and lumbar puncture. AD pathology was examined in accordance to the ATN‐system. Dynamic contrast‐enhanced (DCE) MRI T1 mapping and Patlak analysis using Rocketship software were employed to assess BBB permeability changes.ResultSeventy‐one participants were included (NC = 18, SCD = 36, MCI‐AD = 17). The average age of the cohort was 75 years and the sample consisted of 41% females. The median MMSE scores were 30 for NC and SCD and 27 for the MCI‐AD group. Amyloid pathology, measured in the CSF, was detected in 11% of the NC group (n = 2), 58 % of SCD (n = 21) and 29% of MCI/AD (n = 5). Bilateral BBB dysfunction was identified in 44% of NC (n = 8), in 31% of SCD (n = 11) and 24% of MCI‐AD (n = 4), additionally unilateral BBB dysfunction has been identified in 22% of NC (n = 4), 25% of SCD (n = 9) and 41% of MCI‐AD (n = 7).ConclusionBy using DCE MRI T1 mapping a surprisingly high proportion of increased BBB permeability in the hippocampus can be detected across all groups. Detailed analyzes will reveal the impact of BBB permeability on cognitive function in SCD.

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    Alzheimer s & Dementia
    Article . 2020 . Peer-reviewed
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      Alzheimer s & Dementia
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    Authors: Quoc Khai Le; Thi Huong Trang Pham; Trung Hieu Nguyen; Thi Diem Thy Huynh; +1 Authors

    Sleep deprivation of high school and university students is currently an actual concerning issue. Sleep deprivation is one of the leading causes of dozing-off during daytime. Usually, the state of drowsiness is very little concerned, but studies on drowsiness show the importance of investigating the frequency of occurrence as well as the need to clarify the cause and propose limited measures appeared dozing-off. Dozing-off is not only an undesirable state and disrupts daily activities, but also provides information on personal health status. In that case, early alertness for dozing-off event is very helpful in preventing unwanted consequences. The study has designed a process to record dozing-off event, then constructed and implemented the hypnogram processing program that evaluated quantitative changes in polysomnography signals at sleep onset, the transition time from wake stage to sleep stage. By analyzing the energy spectrum of the signal and using wavelet transform in combine with the support vector machine algorithm, the research allows a comprehensive evaluation of the state of dozing-off. Determining the exact time of onset of sleep is very important in the study of drowsiness. Extracting the time of this event appears to help develop an application for early warning dozing-off. Besides, it allows making an initial assessment of the condition of the subject when the time of drowsiness begins suddenly. Six recordings from volunteered students were processed from a 45-minute vigilance test. All of the volunteers had no neuropathy and were well explained to the procedures used in this study. The results show that depending on kinds of different applications, signals such as EEG, EOG, or EMG are used individually or in combination to fetch suitable results. The result presented a successful method to distinguish dozing-off event with other stages.

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    Science & Technology Development Journal - Engineering and Technology
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      Science & Technology Development Journal - Engineering and Technology
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    Authors: Génevaux, Jean-Michel;
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      Other literature type . 2020
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    Authors: Taylor, JSH; Davis, Matthew H; Rastle, Kathleen;

    Reading involves transforming arbitrary visual symbols into sounds and meanings. This study interrogated the neural representations in ventral occipitotemporal cortex (vOT) that support this transformation process. Twenty-four adults learned to read 2 sets of 24 novel words that shared phonemes and semantic categories but were written in different artificial orthographies. Following 2 wk of training, participants read the trained words while neural activity was measured with functional MRI. Representational similarity analysis on item pairs from the same orthography revealed that right vOT and posterior regions of left vOT were sensitive to basic visual similarity. Left vOT encoded letter identity and representations became more invariant to position along a posterior-to-anterior hierarchy. Item pairs that shared sounds or meanings, but were written in different orthographies with no letters in common, evoked similar neural patterns in anterior left vOT. These results reveal a hierarchical, posterior-to-anterior gradient in vOT, in which representations of letters become increasingly invariant to position and are transformed to convey spoken language information. Significance Learning to read is the most important milestone in a child’s education. However, controversies remain regarding how readers’ brains transform written words into sounds and meanings. We address these by combining artificial language learning with neuroimaging to reveal how the brain represents written words. Participants learned to read new words written in 2 different alphabets. Following 2 wk of training, we found a hierarchy of brain areas that support reading. Letter position is represented more flexibly from lower to higher visual regions. Furthermore, higher visual regions encode information about word sounds and meanings. These findings advance our understanding of how the brain comprehends language from arbitrary visual symbols.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
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    Europe PubMed Central
    Article . 2019
    Data sources: PubMed Central
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    Apollo
    Article . 2020
    License: CC BY
    Data sources: Datacite
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Apollo
    Other literature type . 2019
    License: CC BY
    Data sources: Apollo
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Proceedings of the National Academy of Sciences
    Article . 2019 . Peer-reviewed
    License: CC BY
    Data sources: Crossref
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Europe PubMed Central
      Article . 2019
      Data sources: PubMed Central
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Apollo
      Article . 2020
      License: CC BY
      Data sources: Datacite
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Apollo
      Other literature type . 2019
      License: CC BY
      Data sources: Apollo
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Proceedings of the National Academy of Sciences
      Article . 2019 . Peer-reviewed
      License: CC BY
      Data sources: Crossref
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Cantor, David;

    While the world is aware of Covid’s devastating effect on the world’s health and economy worldwide, this event has highlighted the need to understand how viruses and other micro infectious events enter and effect the brain contributing to changes in function and behavior. Given that this and other viruses do indeed enter the brain, studies are now being turned to understand possible residual effects on behavior and brain function. More than ever, the need to understand how such infiltration leads to demyelinating and general neuroinflammatory processes and this has been noted effecting frontal lobes and brainstem structures. Initial structural neuroimaging studies have evidenced generalized encephalopathies and damage particularly to medial temporal regions. Studies showing that as much as six months following discharge from hospitalization, there are reports that over 30% of patients are experiencing decline in cognitive functioning and over 20% of patients experience significant mood regulation problems. Functional neuroimaging studies have corroborated structural findings in noting dysfunction as expected changes in the frontal regions. EEG studies have also noted frontal regions with increased delta corresponding to these findings. COVID-19 patients with resultant seizures, focal areas have been identified in the temporal, frontotemporal, and central-parietal regions. This presentation will summarize initial efforts to review a clinical sample of qEEG correlates resulting from COVID infection including sLORETA analyses that can help to understand the scaled vulnerability for certain areas of the brain for such infections and shed more light on why certain qEEG features are likely to be expected in the presence of underlying neuroinflammatory mechanisms. Preliminary cases studies with patients post COVID-19 exposure as well as non-exposed neurotypical cases experiencing the neuroinflammatory effects of the COVID vaccination will be presented and reviewed. These cases will illustrate the emerging findings that evidence increased delta and theta absolute power in bilateral frontal poles, fronto-temporal regions and central-parietal regions and increased volumetric deviations in the frontal and temporal regions by sLORETA analyses with concomitant changes in aspects of cognition and mood regulation. Current vaccines being used to prevent more serious effects of the COVID-19 and potential variants can stimulant the immune system to trigger similar cytokine storms in some individuals and can trigger neuroinflammatory effects on the brain. qEEG may have the ability to provide biomarkers for individuals who may have cytokine storms by any of number of challenges to the immune system.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ International Journa...arrow_drop_down
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    International Journal of Psychophysiology
    Article . 2021 . Peer-reviewed
    License: Elsevier TDM