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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Christopher, Tolleson; Srivatsan, Pallavaram; Chen, Li; John, Fang; +6 Authors

    <b><i>Background:</i></b> Deep brain stimulation (DBS) of the globus pallidus internus is established as efficacious for dystonia, yet the optimal target within this structure is not well defined. Published evidence suggests that spatial normalization provides a better estimate of DBS lead location than traditional methods based on standard stereotactic coordinates. <b><i>Methods:</i></b> We retrospectively reviewed our pallidal implanted dystonia population. Patient imaging scans were morphed into an MRI atlas using a nonlinear image registration algorithm. Active contact locations were projected onto the atlas and clusters analyzed for the degree of variance in two groups: (1) good and poor responders and (2) cervical (CD) and generalized dystonia (GD). <b><i>Results:</i></b> The average active contact location between CD and GD good responders was distinct but not significantly different. The mean active contact for CD poor responders was significantly different from CD responders and GD poor responders in the dorsoventral direction. <b><i>Conclusions:</i></b> A normalized imaging space is arguably more accurate in visualizing postoperative leads. Despite some separation between groups, this data suggests there was not an optimal pallidal target for common dystonia patients. Degrees of variance overlapped due to a large degree of individual target variation. Patient selection may ultimately be the key to maximizing patient outcomes. © 2014 S. Karger AG, Basel

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Stereotactic and Fun...arrow_drop_down
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    Europe PubMed Central
    Other literature type . 2014
    Data sources: PubMed Central
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Stereotactic and Fun...arrow_drop_down
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      Europe PubMed Central
      Other literature type . 2014
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    Authors: Kévin P. Dhondt; Cyrille Mathieu; Marie Chalons; Joséphine M. Reynaud; +3 Authors

    International audience; Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are resistant to henipavirus infection. We report here the susceptibility of mice deleted for the type I interferon receptor (IFNAR-KO) to both HeV and NiV. Intraperitoneally infected mice developed fatal encephalitis, with pathology and immunohistochemical features similar to what was found in humans. Viral RNA was found in the majority of analyzed organs, and sublethally infected animals developed virus-specific neutralizing antibodies. Altogether, these results reveal IFNAR-KO mice as a new small animal model to study HeV and NiV pathogenesis, prophylaxis, and treatment and suggest the critical role of type I interferon signaling in the control of henipavirus infection.

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    Article . 2013
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    The Journal of Infectious Diseases
    Article . 2012 . Peer-reviewed
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      Hal-Diderot
      Article . 2013
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      The Journal of Infectious Diseases
      Article . 2012 . Peer-reviewed
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    Authors: Mobasher, B.; Capak, P.; Scoville, N. Z.; Dahlen, T.; +25 Authors

    We measure photometric redshifts and spectral types for galaxies in the COSMOS survey. We use template fitting technique combined with luminosity function priors and with the option to simultaneously estimate dust extinction (i.e. E(B-V)) for each galaxy.Our estimated redshifts are accurate to i<25 and z~1.2. Using simulations with sampling and noise characteristics similar to those in COSMOS, the accuracy and reliability is estimated for the photometric redshifts as a function of the magnitude limits of the sample, S/N ratios and the number of bands used. From the simulations we find that the ratio of derived 95% confidence interval in the redshift probability distribution to the estimated photometric redshift (D95) can be used to identify and exclude the catastrophic failures in the photometric redshift estimates. We compare the derived redshifts with high-reliability spectroscopic redshifts for a sample of 868 normal galaxies with z < 1.2 from zCOSMOS. Considering different scenarios, depending on using prior, no prior and/or extinction, we compare the photometric and spectroscopic redshifts for this sample. This corresponds to an rms scatter of 0.031, with a small number of outliers (<2.5%). We also find good agreement (rms=0.10) between photometric and spectroscopic redshifts for Type II AGNs. We compare results from our photometric redshift procedure with three other independent codes and find them in excellent agreement. We show preliminary results, based on photometric redshifts for the entire COSMOS sample (to i < 25 mag.). 38 pages; 14 Figures; 7 Tables. Accepted for Publication in ApJS. COSMOS Special Issue

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    The Astrophysical Journal Supplement Series
    Article . 2007 . Peer-reviewed
    Data sources: Crossref
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    https://doi.org/10.48550/arxiv...
    Article . 2006
    License: arXiv Non-Exclusive Distribution
    Data sources: Datacite
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    Other literature type . Preprint . 2006
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      The Astrophysical Journal Supplement Series
      Article . 2007 . Peer-reviewed
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      https://doi.org/10.48550/arxiv...
      Article . 2006
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    Authors: Renzo, Guerrini; Carla, Marini; Massimo, Mantegazza;

    Research in genetics of epilepsy represents an area of great interest both for clinical purposes and for understanding the basic mechanisms of epilepsy. Most mutations in epilepsies without structural brain abnormalities have been identified in ion channel genes, but an increasing number of genes involved in a diversity of functional and developmental processes are being recognized through whole exome or genome sequencing. Targeted molecular diagnosis is now available for different forms of epilepsy. The identification of epileptogenic mutations in patients before epilepsy onset and the possibility of developing therapeutic strategies tested in experimental models may facilitate experimental approaches that prevent epilepsy or decrease its severity. Functional analysis is essential for better understanding pathogenic mechanisms and gene interactions. In vitro experimental systems are either cells that usually do not express the protein of interest or neurons in primary cultures. In vivo/ex vivo systems are organisms or preparations obtained from them (e.g., brain slices), which should better model the complexity of brain circuits and actual pathophysiological conditions. Neurons differentiated from induced pluripotent stem cells generated from the skin fibroblasts of patients have recently allowed the study of mutations in human neurons having the genetic background of a given patient. However, there is remarkable complexity underlying epileptogenesis in the clinical dimension, as reflected by the fact that experimental models have not provided yet results having clinical translation and that, with a few exceptions concerning rare conditions, no new curative treatment has emerged from any genetic finding in epilepsy.

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    Neurotherapeutics
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    Europe PubMed Central
    Other literature type . 2014
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Neurotherapeutics
    Article . 2014 . Peer-reviewed
    License: Elsevier Non-Commercial
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      Neurotherapeutics
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      Europe PubMed Central
      Other literature type . 2014
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      Neurotherapeutics
      Article . 2014 . Peer-reviewed
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    Authors: Jan Tuckermann; Anna Kleiman; Richard Moriggl; Rainer Spanbroek; +10 Authors

    Glucocorticoids (GCs) are widely used in the treatment of allergic skin conditions despite having numerous side effects. Here we use Cre/loxP-engineered tissue- and cell-specific and function-selective GC receptor (GR) mutant mice to identify responsive cell types and molecular mechanisms underlying the antiinflammatory activity of GCs in contact hypersensitivity (CHS). CHS was repressed by GCs only at the challenge phase, i.e., during reexposure to the hapten. Inactivation of the GR gene in keratinocytes or T cells of mutant mice did not attenuate the effects of GCs, but its ablation in macrophages and neutrophils abolished downregulation of the inflammatory response. Moreover, mice expressing a DNA binding-defective GR were also resistant to GC treatment. The persistent infiltration of macrophages and neutrophils in these mice is explained by an impaired repression of inflammatory cytokines and chemokines such as IL-1beta, monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IFN-gamma-inducible protein 10. In contrast TNF-alpha repression remained intact. Consequently, injection of recombinant proteins of these cytokines and chemokines partially reversed suppression of CHS by GCs. These studies provide evidence that in contact allergy, therapeutic action of corticosteroids is in macrophages and neutrophils and that dimerization GR is required.

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    Europe PubMed Central
    Other literature type . 2007
    Data sources: PubMed Central
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    The Journal of Clinical Investigation
    Article . 2007 . Peer-reviewed
    Data sources: Crossref
    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    NARCIS
    Article . 2007
    Data sources: NARCIS
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      Europe PubMed Central
      Other literature type . 2007
      Data sources: PubMed Central
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      The Journal of Clinical Investigation
      Article . 2007 . Peer-reviewed
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      Article . 2007
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    Authors: Grynberg, Alain; Athias, Pierre; Degois, M.;

    Neonatal rat heart cells cultivated in either of two different media which varied only in their serum supplements were transferred to chemically defined medium (Ham's F10) for 24 h before measuring a variety of parameters. The 24-h period of exposure to chemically defined medium was not sufficient to reverse the effects imposed on the cells by the serum used in the first phase of growth. The cells differed in rate and duration of action potentials and contractions. The initial serum composition affected the response of the cells to calcium deficiency. Studies involving the effects of pharmaceutical reagents such as isoproterenol were also influenced by the serum. In attempting to determine the cause and possible mechanism, it was found that mitochondrial membrane permeability for nitroblue tetrazolium (NBT) was unchanged. Although the serum supplements differed in fatty acid composition, the fatty acid profiles of the cell phospholipids were relatively constant. We conclude that (a) the function of the cells is affected by the growth environment, particularly serum; (b) that a short exposure to a uniform chemically defined medium is not sufficient to reverse these effects; and (c) that the differences in effects are not the result of changes in the fatty acid composition of the whole cell phospholipids nor in mitochondrial membrane permeability as measured by NBT.

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    In Vitro Cellular & Developmental Biology
    Article . 1986 . Peer-reviewed
    License: Springer TDM
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao In Vitro Cellular & ...arrow_drop_down
      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      In Vitro Cellular & Developmental Biology
      Article . 1986 . Peer-reviewed
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  • image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    Authors: Iaffaldano, Gampiero; Husson, Laurent; Bunge, H.;

    International audience; Short-term plate motion variations on the order of a few Myr are a powerful probe into the nature of plate boundary forces, as mantle-related buoyancies evolve on longer time-scales. New reconstructions of the ocean-floor spreading record reveal an increasing number of such variations, but the dynamic mechanisms producing them are still unclear. Here we show quantitatively that climate changes may impact the shortterm evolution of plate motion by linking explicitly the observed counter-clockwise rotation of the Indian plate since ~10 Ma to increased erosion and reduced elevation along the eastern Himalayas, due to temporal variations in monsoon intensity. By assimilating observations into empirical relations for the competing contributions of erosion and mountain building, we estimate the first-order decrease in elevation along the eastern Himalayas since initial strengthening of the monsoon. Furthermore, we show with global geodynamic models of the coupled mantle/lithosphere system that the inferred reduction in elevation is consistent with the Indian plate motion record over the same period of time, and that lowered gravitational potential energy in the eastern Himalayas following stronger erosion is a key factor to foster plate convergence in this region. Our study implicates lateral variations in plate coupling and their temporal changes as an efficient source to induce an uncommon form of plate motion where the Euler pole falls within its associated plate.

    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Earth and Planetary ...arrow_drop_down
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    Earth and Planetary Science Letters
    Article . 2011 . Peer-reviewed
    License: Elsevier TDM
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    Article . 2011
    Data sources: Hal-Diderot
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    Authors: Mathieu Santonja; Adriane Aupic-Samain; Estelle Forey; Matthieu Chauvat;

    International audience; Collembola is an abundant group of soil organisms playing a major role on litter decomposition process and nutrient cycling in forest ecosystems. Habitat structure strongly influences Collembola assemblages as plant litter physical characteristics and quantity provide structural niches and determine the outcome of their interactions with predators. Collembola are also extremely sensitive to environmental conditions such as soil temperature that control their demographic parameters and activity. In this context, increasing temperature with the ongoing climate change can have strong impact on Collembola assemblages and their responses to predation either directly by altering their behaviour or indirectly by altering their habitat structure. We therefore examined how the increase of temperature combined to the decrease of specific leaf area (SLA, a major functional plant trait) of the European common oak (Quercus robur L.) and the presence of a centipede predator (Chilopoda Lithobiidae) will affect the abundance of Folsomia candida (Collembola Isotomidae) in a 5-week microcosm experiment. Increasing temperature, decreasing SLA and presence of centipede altered F. candida abundance. We observed a significant temperature × predation interaction suggesting differential effects of increasing temperature on F. candida abundance with and without predator. We also observed a significant SLA × predation interaction highlighting that lower SLA decreases F. candida abundance only in predator presence. Finally, our findings evidenced that increasing temperature and decreasing SLA amplify the negative effect of centipede predation on F. candida abundance, suggesting that both direct and indirect effects of climate change would conjointly strengthen the top-down control of predators on preys.

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    European Journal of Soil Biology
    Article . 2018 . Peer-reviewed
    License: Elsevier TDM
    Data sources: Crossref
    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2018
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    Authors: Ruiz, Susan Mosher; Oscar-Berman, Marlene;

    As the number of women who use alcohol increases, so does the number of women who engage in alcohol abuse and develop alcohol dependence. The recent increased focus on women and gender differences in alcoholism research has largely come about following recognition that the face of alcoholism is changing, with alcoholism rates among men remaining stable and rising among women, particularly in younger women. As such, the need to understand gender differences in both acute and long-term effects of alcohol abuse has never been more critical. Gender differences in the long-term effects of chronic alcoholism on the brain and other systems are currently under debate, often with a focus on proclaiming whether men or women suffer the most impact. However, the story appears to be more complex than that. The issue of how alcoholism interacts with gender is complicated, as gender differences in many factors including alcohol metabolism, alcoholism progression, problematic drinking patterns, neurobiology, hormones, and psychiatric comorbidities will contribute to the differences in structural and functional outcomes observed experimentally across domains of inquiry. While women are now much more commonly included in studies of alcohol's effects on the brain, there remains a need for more explicit examinations of gender effects.

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    Journal of Alcoholism and Drug Dependence
    Article . 2013 . Peer-reviewed
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      Journal of Alcoholism and Drug Dependence
      Article . 2013 . Peer-reviewed
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    Authors: Morau, Dominique; RAKOTONDRAMIARANA, Hery; RANAIVOARISOA, Tojo; ANDRIAMAMONJY, Ando;

    International audience; A green roof is an option for improving a building thermal comfort. The investigation is here performed within the specific climate context of Reunion Island in south hemisphere. This type of roof system involves choice difficulties for plant species that are more favorable to establish that comfort. The objective of this work is to simulate the dynamic behavior of this system towards external requests in wet tropical zones and vis-à-vis influences of certain number of physical parameters related to this system. As long as possible, authors used the electrical analogy method to establish a mathematical model associated to the studied system. Based on this model, a Matlab computing code was finalized. Weather data of Reunion Island were used for simulations; the green roof potential and benefit were highlighted by surveying the temperature gain and the heat flux crossing the roof as well as the energy saving performance. Furthermore, the energy consumption being surveyed while doing sensitivity analysis with Fourier Amplitude Sensitivity Test method, the most influential parameters of the model were identified. Full scale experimental results are provided and consisting in monitoring green roof on the top of a public building. According to the results, we can assert that the green roof decreases heat flux entering through the roof during the day and restrains the restoration of accumulated heat at night. Indeed, the support on which the plantation ground bases affects the building thermal insulation. The experimental data are also conducted to prove the effectiveness of thermal insulation by green roofs in reducing temperature in the building between 5°C and 7°C in relation to plants type and the canopy Leaf Area Index (LAI). A comparison of experimental values and model results is done. Among other uses, this code can be used as a tool for choosing the plants and the drain materials to be experimented on the green roof. The results offer hints to optimize the design and thermal performance of extensive green roofs.

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    Energy Procedia
    Article . 2014 . Peer-reviewed
    License: CC BY NC ND
    Hyper Article en Ligne; Hal-Diderot
    Other literature type . Conference object . 2013
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    Authors: Christopher, Tolleson; Srivatsan, Pallavaram; Chen, Li; John, Fang; +6 Authors

    <b><i>Background:</i></b> Deep brain stimulation (DBS) of the globus pallidus internus is established as efficacious for dystonia, yet the optimal target within this structure is not well defined. Published evidence suggests that spatial normalization provides a better estimate of DBS lead location than traditional methods based on standard stereotactic coordinates. <b><i>Methods:</i></b> We retrospectively reviewed our pallidal implanted dystonia population. Patient imaging scans were morphed into an MRI atlas using a nonlinear image registration algorithm. Active contact locations were projected onto the atlas and clusters analyzed for the degree of variance in two groups: (1) good and poor responders and (2) cervical (CD) and generalized dystonia (GD). <b><i>Results:</i></b> The average active contact location between CD and GD good responders was distinct but not significantly different. The mean active contact for CD poor responders was significantly different from CD responders and GD poor responders in the dorsoventral direction. <b><i>Conclusions:</i></b> A normalized imaging space is arguably more accurate in visualizing postoperative leads. Despite some separation between groups, this data suggests there was not an optimal pallidal target for common dystonia patients. Degrees of variance overlapped due to a large degree of individual target variation. Patient selection may ultimately be the key to maximizing patient outcomes. © 2014 S. Karger AG, Basel

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    Europe PubMed Central
    Other literature type . 2014
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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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      Europe PubMed Central
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    Authors: Kévin P. Dhondt; Cyrille Mathieu; Marie Chalons; Joséphine M. Reynaud; +3 Authors

    International audience; Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are resistant to henipavirus infection. We report here the susceptibility of mice deleted for the type I interferon receptor (IFNAR-KO) to both HeV and NiV. Intraperitoneally infected mice developed fatal encephalitis, with pathology and immunohistochemical features similar to what was found in humans. Viral RNA was found in the majority of analyzed organs, and sublethally infected animals developed virus-specific neutralizing antibodies. Altogether, these results reveal IFNAR-KO mice as a new small animal model to study HeV and NiV pathogenesis, prophylaxis, and treatment and suggest the critical role of type I interferon signaling in the control of henipavirus infection.

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    Article . 2013
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