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395 Research products

  • Neuroinformatics
  • 2023-2023
  • French National Research Agency (ANR)

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Bayram, Mariam; Palluel-Germain, Richard; Lebon, Florent; Durand, Edith; +2 Authors

    International audience; Studies showed that motor expertise was found to induce improvement in language processing. Grounded and situated approaches attributed this effect to an underlying automatic simulation of the motor experience elicited by action words, similar to motor imagery (MI), and suggest shared representations of action conceptualization. Interestingly, recent results also suggest that the mental simulation of action by MI training induces motor-system modifications and improves motor performance. Consequently, we hypothesize that, since MI training can induce motor-system modifications, it could be used to reinforce the functional connections between motor and language system, and could thus lead to improved language performance. Here, we explore these potential interactions by reviewing recent fundamental and clinical literature in the action-language and MI domains. We suggested that exploiting the link between action language and MI could open new avenues for complementary language improvement programs. We summarize the current literature to evaluate the rationale behind this novel training and to explore the mechanisms underlying MI and its impact on language performance.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Human N...arrow_drop_down
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    Frontiers in Human Neuroscience
    Article . 2023 . Peer-reviewed
    License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Human N...arrow_drop_down
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      Frontiers in Human Neuroscience
      Article . 2023 . Peer-reviewed
      License: CC BY
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    Authors: Alain Durmus; Andreas Eberle; Arnaud Guillin; Katharina Schuh;

    We develop a new approach to study the long time behaviour of solutions to nonlinear stochastic differential equations in the sense of McKean, as well as propagation of chaos for the corresponding mean-field particle system approximations. Our approach is based on a sticky coupling between two solutions to the equation. We show that the distance process between the two copies is dominated by a solution to a one-dimensional nonlinear stochastic differential equation with a sticky boundary at zero. This new class of equations is then analyzed carefully. In particular, we show that the dominating equation has a phase transition. In the regime where the Dirac measure at zero is the only invariant probability measure, we prove exponential convergence to equilibrium both for the one-dimensional equation, and for the original nonlinear SDE. Similarly, propagation of chaos is shown by a componentwise sticky coupling and comparison with a system of one dimensional nonlinear SDEs with sticky boundaries at zero. The approach applies to equations without confinement potential and to interaction terms that are not of gradient type. 46 pages

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Stochastic Partial D...arrow_drop_down
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    Stochastic Partial Differential Equations Analysis and Computations
    Article . 2023 . Peer-reviewed
    License: CC BY
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    Other literature type . Preprint . 2022
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    https://doi.org/10.48550/arxiv...
    Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Stochastic Partial D...arrow_drop_down
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      Stochastic Partial Differential Equations Analysis and Computations
      Article . 2023 . Peer-reviewed
      License: CC BY
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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      Other literature type . Preprint . 2022
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      https://doi.org/10.48550/arxiv...
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    Authors: Adam Rançon; Nicolas Dupuis;

    We determine the two-body contact in a planar Bose gas confined by a transverse harmonic potential, using the nonperturbative functional renormalization group. We use the three-dimensional thermodynamic definition of the contact where the latter is related to the derivation of the pressure of the quasi-two-dimensional system with respect to the three-dimensional scattering length of the bosons. Without any free parameter, we find a remarkable agreement with the experimental data of Zou {\it et al.} [Nat. Comm. {\bf 12}, 760 (2021)] from low to high temperatures, including the vicinity of the Berezinskii-Kosterlitz-Thouless transition. We also show that the short-distance behavior of the pair distribution function and the high-momentum behavior of the momentum distribution are determined by two contacts: the three-dimensional contact for length scales smaller than the characteristic length $\ell_z=\sqrt{\hbar/m\omega_z}$ of the harmonic potential and, for length scales larger than $\ell_z$, an effective two-dimensional contact, related to the three-dimensional one by a geometric factor depending on $\ell_z$. Comment: v1) 6+10 pages, 2+1 figures; v2) 6+12 pages, 2+4 figures, published version

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    Physical Review Letters
    Article . 2023 . Peer-reviewed
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    https://doi.org/10.48550/arxiv...
    Article . 2022
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ arXiv.org e-Print Ar...arrow_drop_down
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      image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
      Physical Review Letters
      Article . 2023 . Peer-reviewed
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      Article . 2022
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Yabo, Agustín Gabriel; Safey El Din, Mohab; Caillau, Jean-Baptiste; Gouzé, Jean-Luc;

    International audience; We describe microbial growth and production of value-added chemical compounds in a continuous bioreactor through a dynamical system and we study the local stability of the equilibrium of interest by means of the classical Routh-Hurwitz criterion. The mathematical model considers various biological and structural parameters related to the bioprocess (concentration of substrate inflow, constants of the microchemical reactions, steady-state mass fractions of intracellular proteins, etc.) and thus, the stability condition is given in terms of these parameters. This boils down to deciding the consistency of a system of polynomial inequalities over the reals, which is challenging to solve from an analytical perspective, and out of reach even for traditional computational software designed to solve such problems. We show how to adapt classical techniques for solving polynomial systems to cope with this problem within a few minutes by leveraging its structural properties, thus completing the stability analysis of our model. The paper is accompanied by a Maple worksheet available online.

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    MathematicS In Action
    Article . 2023 . Peer-reviewed
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      MathematicS In Action
      Article . 2023 . Peer-reviewed
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    Authors: Anne Benoit; Louis-Claude Canon; Redouane Elghazi; Pierre-Cyrille Héam;

    International audience; Scheduling independent tasks on a parallel platform is a widely-studied problem, in particular when the goal is to minimize the total execution time, or makespan (P||C_max problem in Graham's notations). Also, many applications do not consist of sequential tasks, but rather parallel tasks, either rigid, with a fixed degree of parallelism, or moldable, with a variable degree of parallelism (i.e., for which we can decide at the execution on how many processors they are executed). Furthermore, since the energy consumption of data centers is a growing concern, both from an environmental and economical point of view, minimizing the energy consumption of a schedule is a main challenge to be addressed. One can then decide, for each task, on how many processors it is executed, and at which speed the processors are operated, with the goal to minimize the total energy consumption. We further focus on co-schedules, where tasks are partitioned into shelves, and we prove that the problem of minimizing the energy consumption remains NP-complete when static energy is consumed during the whole duration of the application. We are however able to provide an optimal algorithm for the schedule within one shelf, i.e., for a set of tasks that start at the same time. Several approximation results are derived, both with discrete and continuous speed models, and extensive simulations are performed to show the performance of the proposed algorithms.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hyper Article en Lig...arrow_drop_down
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    Journal of Parallel and Distributed Computing
    Article . 2023 . Peer-reviewed
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      Journal of Parallel and Distributed Computing
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    Authors: Mireia Medrano; Wissal Allaoui; Mathias Van Bulck; Sofie Thys; +8 Authors

    Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated in multiple processes, such as circadian regulation, energy homeostasis, reward processing and stress coping. Although the central expression of NMU has been addressed previously, the lack of specific and sensitive tools has prevented a comprehensive characterization of NMU-expressing neurons in the brain. We have generated a knock-in mouse model constitutively expressing Cre recombinase under the Nmu promoter. We have validated the model using a multi-level approach based on quantitative reverse-transcription polymerase chain reactions, in situ hybridization, a reporter mouse line and an adenoviral vector driving Cre-dependent expression of a fluorescent protein. Using the Nmu-Cre mouse, we performed a complete characterization of NMU expression in adult mouse brain, unveiling a potential midline NMU modulatory circuit with the ventromedial hypothalamic nucleus (VMH) as a key node. Moreover, immunohistochemical analysis suggested that NMU neurons in the VMH mainly constitute a unique population of hypothalamic cells. Taken together, our results suggest that Cre expression in the Nmu-Cre mouse model largely reflects NMU expression in the adult mouse brain, without altering endogenous NMU expression. Thus, the Nmu-Cre mouse model is a powerful and sensitive tool to explore the role of NMU neurons in mice.

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    Lirias
    Article . 2023
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    Open Biology
    Article . 2023 . Peer-reviewed
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    Open Biology
    Article . 2023
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      Lirias
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      Open Biology
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      Open Biology
      Article . 2023
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    Authors: Denis, Alexandre; Jeannot, Emmanuel; Swartvagher, Philippe;

    International audience; To amortize the cost of MPI communications, distributed parallel HPC applications can overlap network communications with computations in the hope that it improves global application performance. When using this technique, both computations and communications are running at the same time. But computation usually also performs some data movements. Since data for computations and for communications use the same memory system, memory contention may occur when computations are memory-bound and large messages are transmitted through the network at the same time.In this paper we propose a model to predict memory bandwidth for computations and for communications when they are executed side by side, according to data locality and taking contention into account. Elaboration of the model allowed to better understand locations of bottleneck in the memory system and what are the strategies of the memory system in case of contention. The model was evaluated on many platforms with different characteristics, and showed a prediction error in average lower than 4 %.

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    International Journal of Networking and Computing
    Article . 2023 . Peer-reviewed
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      International Journal of Networking and Computing
      Article . 2023 . Peer-reviewed
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    Authors: Alestra, Claire; Cette, Gilbert; Chouard, Valérie; Lecat, Rémy;

    This paper highlights how technology can contribute to reaching the COP21 goals of net zero CO2 emissions and global warming below 2°C at the end of the century. It uses the ACCL model, particularly adapted to quantify the consequences of energy price shocks and technology improvements on CO2 emissions, temperature changes, climate damage and GDP. Our simulations show that without climate policies, i.e. a 'business as usual' scenario, the warming may be +4 to +5°C in 2100, with considerable climate damage. We also find that an acceleration in 'usual technical progress'-not targeted at reducing greenhouse gas intensity-makes global warming and climate damage worse than the 'business as usual' scenario. According to our estimates, the world does not achieve climate goals in 2100 without technological changes to avoid CO2 emissions. To hit such climatic targets, intervening only through the relative price of different energy types, e.g. via a carbon tax, requires challenging hypotheses of international coordination and price increase for polluting energies. We assess a multilever climate strategy, associating diverse price and technology measures. This mix combines energy efficiency gains, carbon sequestration, and a decrease of 3% per year in the relative price of noncarbon-emitting electricity with a 1 to 1.5% annual rise in the relative price of our four polluting energy sources. None of these components alone is sufficient to reach climate objectives. Our last and most important finding is that our composite scenario achieves the climate goals.

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    Hyper Article en Ligne; HAL AMU
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    Applied Economics
    Article . 2023 . Peer-reviewed
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    Authors: Katja Heuer; Nicolas Traut; Alexandra Allison de Sousa; Sofie Louise Valk; +2 Authors

    Posted December 30, 2022 on bioRxiv.; International audience; The process of brain folding is thought to play an important role in the development and organisation of the cerebrum and the cerebellum. The study of cerebellar folding is challenging due to the small size and abundance of its folia. In consequence, little is known about its anatomical diversity and evolution. We constituted an open collection of histological data from 56 mammalian species and manually segmented the cerebrum and the cerebellum. We developed methods to measure the geometry of cerebellar folia and to estimate the thickness of the molecular layer. We used phylogenetic comparative methods to study the diversity and evolution of cerebellar folding and its relationship with the anatomy of the cerebrum. Our results show that the evolution of cerebellar and cerebral anatomy follows a stabilising selection process. We observed two groups of phenotypes changing concertedly through evolution: a group of ‘diverse’ phenotypes – varying over several orders of magnitude together with body size, and a group of ‘stable’ phenotypes varying over less than 1 order of magnitude across species. Our analyses confirmed the strong correlation between cerebral and cerebellar volumes across species, and showed in addition that large cerebella are disproportionately more folded than smaller ones. Compared with the extreme variations in cerebellar surface area, folial anatomy and molecular layer thickness varied only slightly, showing a much smaller increase in the larger cerebella. We discuss how these findings could provide new insights into the diversity and evolution of cerebellar folding, the mechanisms of cerebellar and cerebral folding, and their potential influence on the organisation of the brain across species.

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    eLife
    Article . 2023
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    eLife
    Article . 2023 . Peer-reviewed
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    MPG.PuRe
    Article . 2023
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      eLife
      Article . 2023
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      MPG.PuRe
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    Authors: Rahul Dandekar; P. L. Krapivsky; Kirone Mallick;

    We consider an infinite system of particles on a line performing identical Brownian motions and interacting through the $|x-y|^{-s}$ Riesz potential, causing the over-damped motion of particles. We investigate fluctuations of the integrated current and the position of a tagged particle. We show that for $0 < s < 1$, the standard deviations of both quantities grow as $t^{\frac{s}{2(1+s)}}$. When $s>1$, the interactions are effectively short-ranged, and the universal sub-diffusive $t^\frac{1}{4}$ growth emerges with only amplitude depending on the exponent. We also show that the two-time correlations of the tagged-particle position have the same form as for fractional Brownian motion. 13 pages; v2: minor updates, added references

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    image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
    https://doi.org/10.1103/physre...
    Article . 2023 . Peer-reviewed
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    https://doi.org/10.48550/arxiv...
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      https://doi.org/10.1103/physre...
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    Authors: Bayram, Mariam; Palluel-Germain, Richard; Lebon, Florent; Durand, Edith; +2 Authors

    International audience; Studies showed that motor expertise was found to induce improvement in language processing. Grounded and situated approaches attributed this effect to an underlying automatic simulation of the motor experience elicited by action words, similar to motor imagery (MI), and suggest shared representations of action conceptualization. Interestingly, recent results also suggest that the mental simulation of action by MI training induces motor-system modifications and improves motor performance. Consequently, we hypothesize that, since MI training can induce motor-system modifications, it could be used to reinforce the functional connections between motor and language system, and could thus lead to improved language performance. Here, we explore these potential interactions by reviewing recent fundamental and clinical literature in the action-language and MI domains. We suggested that exploiting the link between action language and MI could open new avenues for complementary language improvement programs. We summarize the current literature to evaluate the rationale behind this novel training and to explore the mechanisms underlying MI and its impact on language performance.

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    Frontiers in Human Neuroscience
    Article . 2023 . Peer-reviewed
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      Frontiers in Human Neuroscience
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    Authors: Alain Durmus; Andreas Eberle; Arnaud Guillin; Katharina Schuh;

    We develop a new approach to study the long time behaviour of solutions to nonlinear stochastic differential equations in the sense of McKean, as well as propagation of chaos for the corresponding mean-field particle system approximations. Our approach is based on a sticky coupling between two solutions to the equation. We show that the distance process between the two copies is dominated by a solution to a one-dimensional nonlinear stochastic differential equation with a sticky boundary at zero. This new class of equations is then analyzed carefully. In particular, we show that the dominating equation has a phase transition. In the regime where the Dirac measure at zero is the only invariant probability measure, we prove exponential convergence to equilibrium both for the one-dimensional equation, and for the original nonlinear SDE. Similarly, propagation of chaos is shown by a componentwise sticky coupling and comparison with a system of one dimensional nonlinear SDEs with sticky boundaries at zero. The approach applies to equations without confinement potential and to interaction terms that are not of gradient type. 46 pages

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    Stochastic Partial Differential Equations Analysis and Computations
    Article . 2023 . Peer-reviewed
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