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  • Neuroinformatics
  • 2023-2023
  • Spanish

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Medina-Alva, María del Pilar; Alvarado-Merino, Rosa; Velásquez-Acosta, Pablo;

    RESUMEN La encefalopatía hipóxico-isquémica (EHI) es el síndrome neurológico causado por la asfixia perinatal. La hipotermia terapéutica (HT) ha demostrado reducir la mortalidad y morbilidad asociadas a EHI. Se realizó un estudio descriptivo retrospectivo con 30 recién nacidos con EHI moderada y severa que recibieron HT en la Unidad de Cuidados Intensivos del Instituto Materno Perinatal desde setiembre de 2017 a noviembre de 2020. Nueve de los casos fueron severos (30 %). El tiempo promedio de ingreso a HT fue 3.4 horas de vida. No se registraron efectos adversos importantes atribuibles a HT. Todos los pacientes severos tuvieron crisis epilépticas, ecografías cerebrales de ingreso y resonancias con anormalidades. La mortalidad fue de 20.0 %, aunque fue significativamente menor en el grupo con EHI moderada. Se identificaron las características de presentación clínica, electrográfica y radiológica de los neonatos con EHI que recibieron hipotermia terapéutica, la cual se muestra como un procedimiento seguro y efectivo. ABSTRACT Hypoxic-ischemic encephalopathy (HIE) is the neurological syndrome caused by perinatal asphyxia. Therapeutic hypothermia (TH) has been shown to reduce HIE-associated morbidity and mortality. A descriptive and retrospective study with 30 newborns with moderate and severe HIE who underwent TH in the Intensive Care Unit (ICU) of Instituto Materno Perinatal, from September 2017 until November 2020. Nine patients were severely affected (30%). The average tome for being admitted in the ICU was at 3.4 hours of life. No important adverse effects attributable to TH were observed. All severely affected patients experienced epileptic crises, and abnormal cerebral ultrasonography and magnetic resonance imaging studies on admission. Mortality was 20.0%, but it was significantly lower in the group with moderate HIE. Clinical, electrographic, and radiological characteristics of neonates with HIE who underwent therapeutic hypothermia were identified. This procedure has been shown to be safe and effective.

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  • Authors: Valdenebro Sánchez, Jorge; García Alarcón, Victoria;

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    Authors: Piedad Acurio-Padilla; Carol Estefanía Sánchez-Palacios; Aldemar Alejandro Monsalve-Guamán;

    Introduction: the neuronavigation system is a technological advance whose role is to allow real-time visualization of intracranial structures, which are obtained from preoperative images and reconstructed in third dimension, which are projected through the screen. Objective: to characterize the advantages and disadvantages of neuroimaging and neuronavigation. Method: medical-scientific electronic databases such as MEDLINE, Pubmed, Clinical Key, Scopus and Web of Science involving certain articles of medical relevance, in addition to books recognized within the scientific community, for which we used the keywords "neurosurgery", "neuronavigation", whose search period was between 2018 and 2022. About 22 publications were collected of which 10 have been considered for the realization of this literature review. Results: the advent of this technology has served to perform several highly complex neurosurgical procedures in a safer and more precise way, including minimally invasive ones, improving the accuracy of the approach and reducing the risks of complications, which is why it plays a fundamental role in the neurosurgeon's accuracy while making the success of operations feasible with a lower risk. Conclusions: neuronavigation is a tool that considerably decreases surgical time, craniotomy dimensions and therefore decreases complications and lesions of adjacent structures, improving prognosis and decreasing sequelae in the patients studied.

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    Authors: Thieulin-Pardo, Hélène; Rochwert-Zuili, Patricia;

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  • Authors: Richer-Rossi, Françoise;

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  • Authors: Coussement-Boillot, Laetitia;

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    Authors: Thieulin-Pardo, Hélène;
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    Authors: Rico-Fernández, Eduardo; Fraire-Martínez, María Inés; Gutiérrez-Palomares, María Luisa; Núñez-Enríquez, Juan Carlos; +1 Authors

    {"references": ["1.\tWorld Health Organization. International Statistical Classification of Diseases and related health problems: Volume 3 alphabetical index. 10th ed. Geneva: WHO; 2004. 677 pp.", "2.\tJim\u00e9nez-Acosta YC, G\u00f3mez-Garnica MF, Contreras-Peregrina MR, et al. Perfil epidemiol\u00f3gico del reci\u00e9n nacido pret\u00e9rmino en una instituci\u00f3n privada del Occidente de M\u00e9xico. Rev Med MD. 2016;7.8(4):270-4.", "3.\tPadilla-Mu\u00f1oz H, Guti\u00e9rrez-Padilla JA, Gonz\u00e1lez-S\u00e1nchez R, et al. Perfil de morbilidad y mortalidad de la UCINEX del Hospital Civil de Guadalajara Fray Antonio Alcalde del 2005 al 2012. Rev Med MD. 2014;5.6(4):182-8.", "4.\tGarc\u00eda-Hern\u00e1ndez HA, Valle-Delgado E, Angulo-Castellanos E, et al. Morbilidad y mortalidad de un Centro Regional en Atenci\u00f3n Neonatal del Occidente de M\u00e9xico (2012- 2015). Rev Med MD. 2016;7.8(4):247-53.", "5.\tCupen K, Barran A, Singh V, et al. Risk Factors Associated with Preterm Neonatal Mortality: A Case Study Using Data from Mt. Hope Women's Hospital in Trinidad and Tobago. Children (Basel). 2017;4(12):108. doi: 10.3390/children4120108", "6.\tHowson CP, Kinney MV, McDougall L, et al. Born Too Soon Preterm Birth Action Group. Born too soon: preterm birth matters. Reprod Health. 2013;10(Suppl 1):S1. doi: 10.1186/1742-4755-10-S1-S1", "7.\tSecretar\u00eda de Salud. Norma Oficial Mexicana NOM 007-SSA2-2016, Para la atenci\u00f3n de la mujer en el embarazo, parto y puerperio, y de la persona reci\u00e9n nacida. M\u00e9xico: Secretar\u00eda de Salud; 2016. Disponible en: https://www.dof.gob.mx/nota_detalle.php?codigo=5432289&fecha=07/04/2016#gsc.tab=0", "8.\tMosley WH, Chen LC. An analytical framework for the study of child survival in developing countries. 1984. Bull World Health Organ. 2003;81(2):140-5.", "9.\tBlencowe H, Cousens S, Chou D, et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10 (Suppl 1):1-14. doi: 10.1186/1742-4755-10-S1-S2", "10.\tGlass HC, Costarino AT, Stayer SA, et al. Outcomes for extremely premature infants. Anesth Analg. 2015;120(6):1337-51. doi: 10.1213/ANE.0000000000000705", "11.\tKobaly K, Schluchter M, Minich N, et al. Outcomes of extremely low birth weight (<1 kg) and extremely low gestational age (<28 weeks) infants with bronchopulmonary dysplasia: effects of practice changes in 2000 to 2003. Pediatrics. 2008;121(1):73-81. doi: 10.1542/peds.2007-1444", "12.\tDreyfus-Brisac C. Neonatal electroencephalography. In: Scarpelli EM, Cosmi EV, editors. Perinatal Medicine. New York: Raven Press; 1979. pp. 397-472.", "13.\tVerma UL, Archbald F, Tejani NA, et al. Cerebral function monitor in the neonate. I: Normal patterns. Dev Med Child Neurol. 1984;26(2):154-61. doi: 10.1111/j.1469-8749", "14.\tHellstr\u00f6m-Westas L, Ros\u00e9n I, Svenningsen NW. Cerebral function monitoring during the first week of life in extremely small low birthweight (ESLBW) infants. Neuropediatrics. 1991;22(1):27-32. doi: 10.1055/s-2008-1071411", "15.\tBurdjalov VF, Baumgart S, Spitzer AR. Cerebral function monitoring: a new scoring system for the evaluation of brain maturation in neonates. Pediatrics. 2003;112(4):855-61. doi: 10.1542/peds.112.4.855", "16.\tFrenkel N, Friger M, Meledin I, et al. Neonatal seizure recognition--comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings. Clin Neurophysiol. 2011;122(6):1091-7. doi: 10.1016/j.clinph.2010.09.028", "17.\tSoubasi V, Mitsakis K, Sarafidis K, et al. Early abnormal amplitude-integrated electroencephalography (aEEG) is associated with adverse short-term outcome in premature infants. Eur J Paediatr Neurol. 2012;16(6):625-30. doi: 10.1016/j.ejpn.2012.02.008", "18.\tSchmidt-Mellado G, Pillay K, Adams E, et al. The impact of premature extrauterine exposure on infants' stimulus-evoked brain activity across multiple sensory systems. Neuroimage Clin. 2022;33:1-15. doi: 10.1016/j.nicl.2021.102914", "19.\tPineda RG, Neil J, Dierker D, et al. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014;164(1):1-22. doi: 10.1016/j.jpeds.2013.08.047", "20.\tWallois, F, Routier, L, Bourel Ponchel, E. Chapter 25: Impact of prematurity on neurodevelopment. in: Handbook of Clinical Neurology. Gallagher A, Bulteau C, Cohen D, editors. Amsterdam: Elsevier; 2020. pp. 341-75.", "21.\tAdams JN, Feldman HM, Huffman LC, et al. Sensory processing in preterm preschoolers and its association with executive function. Early Hum Dev. 2015;91(3):227-33. doi: 10.1016/j.earlhumdev.2015.01.013", "22.\tMwaniki MK, Atieno M, Lawn JE, et al. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet. 2012;379(9814):445-52. doi: 10.1016/S0140-6736(11)61577-8", "23.\tMizrahi EM, Hrachovy RA. Atlas of Neonatal Electroencephalography. 4a ed. Nueva York: Demos Medical Publishing; 2015.", "24.\tFogtmann EP, Plomgaard AM, Greisen G, et al. Prognostic Accuracy of Electroencephalograms in Preterm Infants: A Systematic Review. Pediatrics. 2017;139(2):1-16. doi: 10.1542/peds.2016-1951", "25.\tLe Bihannic A, Beauvais K, Busnel A, et al. Prognostic value of EEG in very premature newborns. Arch Dis Child Fetal Neonatal Ed. 2012;97(2):1-5. doi: 10.1136/adc.2010.204735", "26.\tSelton D, Andre M, Debruille C, et al. Cognitive outcome at 5 years in very premature children without severe early cerebral abnormalities. Relationships with EEG at 6 weeks after birth. Neurophysiol Clin. 2013;43(5-6):289-97. doi: 10.1016/j.neucli.2013.09.003", "27.\tSelton D, Andr\u00e9 M, Debruille C, et al. EEG at 6 weeks of life in very premature neonates. Clin Neurophysiol. 2010;121(6):818-22. doi: 10.1016/j.clinph.2009.11.006"]} Abstract Background: The electroencephalogram (EEG) in the newborn period is highly superior to the clinical exam in the detection and prognosis of brain dysfunctions, since it allows continuous functional documentation of the brain at the patient's bedside in a non-invasive way. However, there is still some disagreement about these findings. Objective: To describe the electroencephalographic findings in newborns with a history of prematurity. Material and methods: Cross-sectional, descriptive, retrospective study. The inclusion criteria were: newborns with a history of prematurity, regardless of gender, who underwent an EEG from June 2017 to June 2021. Patients with incomplete electroencephalographic records or clinical records without complete data were excluded; patients using sedatives (thiopental, fentanyl, midazolam, diazepam) were eliminated from the study. Results: 107 patients (37 women and 70 men) with a history of prematurity were included, with a mean gestational age at birth of 30.9 WOG ± 3.25. Electroencephalographic findings were normal in 40%, abnormal in 32%, and immature in 28%. The most frequent abnormal finding was focal paroxysmal activity in 86%. 93.4% of the participants presented comorbidities, the most frequent being neurological. Conclusion: Preterm neonates are at high risk of neurologic sequelae, and EEG is a sensitive method for assessing neuromotor and cognitive prognosis. In our study population, one-third had abnormal findings. Early postnatal screening is helpful, but additional records are usually needed to detect high-risk newborns. It would be important to continue studying this line of research in pediatrics. Resumen Introducción: el electroencefalograma (EEG) en el periodo neonatal es muy superior al examen clínico en la detección y pronóstico de disfunciones cerebrales, pues permite hacer una documentación funcional cerebral continua y no invasiva junto a la cama del paciente. Sin embargo, todavía hay cierto desacuerdo sobre estos hallazgos. Objetivo: describir los hallazgos electroencefalográficos en recién nacidos (RN) con antecedente de prematurez. Material y métodos: estudio transversal, descriptivo, retrospectivo. Los criterios de inclusión fueron: RN con antecedente de prematurez, sin distinción de género, a quienes se les haya hecho un EEG de junio de 2017 a junio de 2021. Se excluyeron pacientes con registro electroencefalográfico incompleto o expediente clínico sin datos completos; se eliminaron del estudio pacientes que usaran sedantes (tiopental, fentanilo, midazolam, diazepam). Resultados: se incluyeron 107 pacientes (37 mujeres y 70 hombres) con antecedente de prematurez, con una edad gestacional media al nacer de 30.9 SDG ± 3.25. Los hallazgos de EEG fueron normales en 40%, anormales en 32% e inmaduros en 28%. El hallazgo anormal más frecuente fue la actividad paroxística focal en 86%. El 93.4% de los participantes presentaban comorbilidades, sobre todo neurológicas. Conclusión: los RN pretérmino tienen un alto riesgo de secuelas neurológicas y el EEG es un método sensible para evaluar el pronóstico neuromotor y cognitivo. En nuestra población un tercio tuvo hallazgos anormales. El rastreo posnatal temprano es útil, pero se necesitan registros adicionales para detectar RN de alto riesgo. Es importante continuar esta línea de investigación en pediatría.

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    Authors: Hirel-Wouts, Sophie;

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    Authors: Medina-Alva, María del Pilar; Alvarado-Merino, Rosa; Velásquez-Acosta, Pablo;

    RESUMEN La encefalopatía hipóxico-isquémica (EHI) es el síndrome neurológico causado por la asfixia perinatal. La hipotermia terapéutica (HT) ha demostrado reducir la mortalidad y morbilidad asociadas a EHI. Se realizó un estudio descriptivo retrospectivo con 30 recién nacidos con EHI moderada y severa que recibieron HT en la Unidad de Cuidados Intensivos del Instituto Materno Perinatal desde setiembre de 2017 a noviembre de 2020. Nueve de los casos fueron severos (30 %). El tiempo promedio de ingreso a HT fue 3.4 horas de vida. No se registraron efectos adversos importantes atribuibles a HT. Todos los pacientes severos tuvieron crisis epilépticas, ecografías cerebrales de ingreso y resonancias con anormalidades. La mortalidad fue de 20.0 %, aunque fue significativamente menor en el grupo con EHI moderada. Se identificaron las características de presentación clínica, electrográfica y radiológica de los neonatos con EHI que recibieron hipotermia terapéutica, la cual se muestra como un procedimiento seguro y efectivo. ABSTRACT Hypoxic-ischemic encephalopathy (HIE) is the neurological syndrome caused by perinatal asphyxia. Therapeutic hypothermia (TH) has been shown to reduce HIE-associated morbidity and mortality. A descriptive and retrospective study with 30 newborns with moderate and severe HIE who underwent TH in the Intensive Care Unit (ICU) of Instituto Materno Perinatal, from September 2017 until November 2020. Nine patients were severely affected (30%). The average tome for being admitted in the ICU was at 3.4 hours of life. No important adverse effects attributable to TH were observed. All severely affected patients experienced epileptic crises, and abnormal cerebral ultrasonography and magnetic resonance imaging studies on admission. Mortality was 20.0%, but it was significantly lower in the group with moderate HIE. Clinical, electrographic, and radiological characteristics of neonates with HIE who underwent therapeutic hypothermia were identified. This procedure has been shown to be safe and effective.

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  • Authors: Valdenebro Sánchez, Jorge; García Alarcón, Victoria;

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    Authors: Piedad Acurio-Padilla; Carol Estefanía Sánchez-Palacios; Aldemar Alejandro Monsalve-Guamán;

    Introduction: the neuronavigation system is a technological advance whose role is to allow real-time visualization of intracranial structures, which are obtained from preoperative images and reconstructed in third dimension, which are projected through the screen. Objective: to characterize the advantages and disadvantages of neuroimaging and neuronavigation. Method: medical-scientific electronic databases such as MEDLINE, Pubmed, Clinical Key, Scopus and Web of Science involving certain articles of medical relevance, in addition to books recognized within the scientific community, for which we used the keywords "neurosurgery", "neuronavigation", whose search period was between 2018 and 2022. About 22 publications were collected of which 10 have been considered for the realization of this literature review. Results: the advent of this technology has served to perform several highly complex neurosurgical procedures in a safer and more precise way, including minimally invasive ones, improving the accuracy of the approach and reducing the risks of complications, which is why it plays a fundamental role in the neurosurgeon's accuracy while making the success of operations feasible with a lower risk. Conclusions: neuronavigation is a tool that considerably decreases surgical time, craniotomy dimensions and therefore decreases complications and lesions of adjacent structures, improving prognosis and decreasing sequelae in the patients studied.

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    Authors: Thieulin-Pardo, Hélène; Rochwert-Zuili, Patricia;

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  • Authors: Richer-Rossi, Françoise;

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  • Authors: Coussement-Boillot, Laetitia;

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    Authors: Thieulin-Pardo, Hélène;
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    Authors: Rico-Fernández, Eduardo; Fraire-Martínez, María Inés; Gutiérrez-Palomares, María Luisa; Núñez-Enríquez, Juan Carlos; +1 Authors

    {"references": ["1.\tWorld Health Organization. International Statistical Classification of Diseases and related health problems: Volume 3 alphabetical index. 10th ed. Geneva: WHO; 2004. 677 pp.", "2.\tJim\u00e9nez-Acosta YC, G\u00f3mez-Garnica MF, Contreras-Peregrina MR, et al. Perfil epidemiol\u00f3gico del reci\u00e9n nacido pret\u00e9rmino en una instituci\u00f3n privada del Occidente de M\u00e9xico. Rev Med MD. 2016;7.8(4):270-4.", "3.\tPadilla-Mu\u00f1oz H, Guti\u00e9rrez-Padilla JA, Gonz\u00e1lez-S\u00e1nchez R, et al. Perfil de morbilidad y mortalidad de la UCINEX del Hospital Civil de Guadalajara Fray Antonio Alcalde del 2005 al 2012. Rev Med MD. 2014;5.6(4):182-8.", "4.\tGarc\u00eda-Hern\u00e1ndez HA, Valle-Delgado E, Angulo-Castellanos E, et al. Morbilidad y mortalidad de un Centro Regional en Atenci\u00f3n Neonatal del Occidente de M\u00e9xico (2012- 2015). Rev Med MD. 2016;7.8(4):247-53.", "5.\tCupen K, Barran A, Singh V, et al. Risk Factors Associated with Preterm Neonatal Mortality: A Case Study Using Data from Mt. Hope Women's Hospital in Trinidad and Tobago. Children (Basel). 2017;4(12):108. doi: 10.3390/children4120108", "6.\tHowson CP, Kinney MV, McDougall L, et al. Born Too Soon Preterm Birth Action Group. Born too soon: preterm birth matters. Reprod Health. 2013;10(Suppl 1):S1. doi: 10.1186/1742-4755-10-S1-S1", "7.\tSecretar\u00eda de Salud. Norma Oficial Mexicana NOM 007-SSA2-2016, Para la atenci\u00f3n de la mujer en el embarazo, parto y puerperio, y de la persona reci\u00e9n nacida. M\u00e9xico: Secretar\u00eda de Salud; 2016. Disponible en: https://www.dof.gob.mx/nota_detalle.php?codigo=5432289&fecha=07/04/2016#gsc.tab=0", "8.\tMosley WH, Chen LC. An analytical framework for the study of child survival in developing countries. 1984. Bull World Health Organ. 2003;81(2):140-5.", "9.\tBlencowe H, Cousens S, Chou D, et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10 (Suppl 1):1-14. doi: 10.1186/1742-4755-10-S1-S2", "10.\tGlass HC, Costarino AT, Stayer SA, et al. Outcomes for extremely premature infants. Anesth Analg. 2015;120(6):1337-51. doi: 10.1213/ANE.0000000000000705", "11.\tKobaly K, Schluchter M, Minich N, et al. Outcomes of extremely low birth weight (<1 kg) and extremely low gestational age (<28 weeks) infants with bronchopulmonary dysplasia: effects of practice changes in 2000 to 2003. Pediatrics. 2008;121(1):73-81. doi: 10.1542/peds.2007-1444", "12.\tDreyfus-Brisac C. Neonatal electroencephalography. In: Scarpelli EM, Cosmi EV, editors. Perinatal Medicine. New York: Raven Press; 1979. pp. 397-472.", "13.\tVerma UL, Archbald F, Tejani NA, et al. Cerebral function monitor in the neonate. I: Normal patterns. Dev Med Child Neurol. 1984;26(2):154-61. doi: 10.1111/j.1469-8749", "14.\tHellstr\u00f6m-Westas L, Ros\u00e9n I, Svenningsen NW. Cerebral function monitoring during the first week of life in extremely small low birthweight (ESLBW) infants. Neuropediatrics. 1991;22(1):27-32. doi: 10.1055/s-2008-1071411", "15.\tBurdjalov VF, Baumgart S, Spitzer AR. Cerebral function monitoring: a new scoring system for the evaluation of brain maturation in neonates. Pediatrics. 2003;112(4):855-61. doi: 10.1542/peds.112.4.855", "16.\tFrenkel N, Friger M, Meledin I, et al. Neonatal seizure recognition--comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings. Clin Neurophysiol. 2011;122(6):1091-7. doi: 10.1016/j.clinph.2010.09.028", "17.\tSoubasi V, Mitsakis K, Sarafidis K, et al. Early abnormal amplitude-integrated electroencephalography (aEEG) is associated with adverse short-term outcome in premature infants. Eur J Paediatr Neurol. 2012;16(6):625-30. doi: 10.1016/j.ejpn.2012.02.008", "18.\tSchmidt-Mellado G, Pillay K, Adams E, et al. The impact of premature extrauterine exposure on infants' stimulus-evoked brain activity across multiple sensory systems. Neuroimage Clin. 2022;33:1-15. doi: 10.1016/j.nicl.2021.102914", "19.\tPineda RG, Neil J, Dierker D, et al. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014;164(1):1-22. doi: 10.1016/j.jpeds.2013.08.047", "20.\tWallois, F, Routier, L, Bourel Ponchel, E. Chapter 25: Impact of prematurity on neurodevelopment. in: Handbook of Clinical Neurology. Gallagher A, Bulteau C, Cohen D, editors. Amsterdam: Elsevier; 2020. pp. 341-75.", "21.\tAdams JN, Feldman HM, Huffman LC, et al. Sensory processing in preterm preschoolers and its association with executive function. Early Hum Dev. 2015;91(3):227-33. doi: 10.1016/j.earlhumdev.2015.01.013", "22.\tMwaniki MK, Atieno M, Lawn JE, et al. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet. 2012;379(9814):445-52. doi: 10.1016/S0140-6736(11)61577-8", "23.\tMizrahi EM, Hrachovy RA. Atlas of Neonatal Electroencephalography. 4a ed. Nueva York: Demos Medical Publishing; 2015.", "24.\tFogtmann EP, Plomgaard AM, Greisen G, et al. Prognostic Accuracy of Electroencephalograms in Preterm Infants: A Systematic Review. Pediatrics. 2017;139(2):1-16. doi: 10.1542/peds.2016-1951", "25.\tLe Bihannic A, Beauvais K, Busnel A, et al. Prognostic value of EEG in very premature newborns. Arch Dis Child Fetal Neonatal Ed. 2012;97(2):1-5. doi: 10.1136/adc.2010.204735", "26.\tSelton D, Andre M, Debruille C, et al. Cognitive outcome at 5 years in very premature children without severe early cerebral abnormalities. Relationships with EEG at 6 weeks after birth. Neurophysiol Clin. 2013;43(5-6):289-97. doi: 10.1016/j.neucli.2013.09.003", "27.\tSelton D, Andr\u00e9 M, Debruille C, et al. EEG at 6 weeks of life in very premature neonates. Clin Neurophysiol. 2010;121(6):818-22. doi: 10.1016/j.clinph.2009.11.006"]} Abstract Background: The electroencephalogram (EEG) in the newborn period is highly superior to the clinical exam in the detection and prognosis of brain dysfunctions, since it allows continuous functional documentation of the brain at the patient's bedside in a non-invasive way. However, there is still some disagreement about these findings. Objective: To describe the electroencephalographic findings in newborns with a history of prematurity. Material and methods: Cross-sectional, descriptive, retrospective study. The inclusion criteria were: newborns with a history of prematurity, regardless of gender, who underwent an EEG from June 2017 to June 2021. Patients with incomplete electroencephalographic records or clinical records without complete data were excluded; patients using sedatives (thiopental, fentanyl, midazolam, diazepam) were eliminated from the study. Results: 107 patients (37 women and 70 men) with a history of prematurity were included, with a mean gestational age at birth of 30.9 WOG ± 3.25. Electroencephalographic findings were normal in 40%, abnormal in 32%, and immature in 28%. The most frequent abnormal finding was focal paroxysmal activity in 86%. 93.4% of the participants presented comorbidities, the most frequent being neurological. Conclusion: Preterm neonates are at high risk of neurologic sequelae, and EEG is a sensitive method for assessing neuromotor and cognitive prognosis. In our study population, one-third had abnormal findings. Early postnatal screening is helpful, but additional records are usually needed to detect high-risk newborns. It would be important to continue studying this line of research in pediatrics. Resumen Introducción: el electroencefalograma (EEG) en el periodo neonatal es muy superior al examen clínico en la detección y pronóstico de disfunciones cerebrales, pues permite hacer una documentación funcional cerebral continua y no invasiva junto a la cama del paciente. Sin embargo, todavía hay cierto desacuerdo sobre estos hallazgos. Objetivo: describir los hallazgos electroencefalográficos en recién nacidos (RN) con antecedente de prematurez. Material y métodos: estudio transversal, descriptivo, retrospectivo. Los criterios de inclusión fueron: RN con antecedente de prematurez, sin distinción de género, a quienes se les haya hecho un EEG de junio de 2017 a junio de 2021. Se excluyeron pacientes con registro electroencefalográfico incompleto o expediente clínico sin datos completos; se eliminaron del estudio pacientes que usaran sedantes (tiopental, fentanilo, midazolam, diazepam). Resultados: se incluyeron 107 pacientes (37 mujeres y 70 hombres) con antecedente de prematurez, con una edad gestacional media al nacer de 30.9 SDG ± 3.25. Los hallazgos de EEG fueron normales en 40%, anormales en 32% e inmaduros en 28%. El hallazgo anormal más frecuente fue la actividad paroxística focal en 86%. El 93.4% de los participantes presentaban comorbilidades, sobre todo neurológicas. Conclusión: los RN pretérmino tienen un alto riesgo de secuelas neurológicas y el EEG es un método sensible para evaluar el pronóstico neuromotor y cognitivo. En nuestra población un tercio tuvo hallazgos anormales. El rastreo posnatal temprano es útil, pero se necesitan registros adicionales para detectar RN de alto riesgo. Es importante continuar esta línea de investigación en pediatría.

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