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Warwick University

Warwick University

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224 Projects, page 1 of 45
  • Funder: WT Project Code: 096730
    Funder Contribution: 85,181 GBP

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  • Funder: NIH Project Code: 1R01GM068611-01
    Funder Contribution: 162,540 USD
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  • Funder: WT Project Code: 065739
    Funder Contribution: 10,610 GBP
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  • Funder: WT Project Code: 062366
    Funder Contribution: 125,380 GBP
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  • Funder: WT Project Code: 202534
    Funder Contribution: 2,000 GBP

    This project aims to develop novel insecticide based techniques to reduce the Triatomine bug infestation rates in Bolivian households, vectors of Trypanosoma cruzi causing Chagas disease in animals and humans. The disease affects all ages and presents as acute to lifelong chronic cardiac and visceral pathologies leading to slow and painful death; there is no drugs against T. cruzi once in the chronic phase. The highest incidence in the world is in the indigenous communities in the Bolivian Chaco region where cumulative infection prevalence reaches 80% by adult age. Peridomestic animals (dogs/chickens) act as blood sources to maintain the bug population and house re-infestation. Triatomid bugs blood-feed on mammalian hosts in order to grow (5 nymph instar development stages) and for females to produce eggs. To reduce the disease burden relies on vector control, however current approaches comprising indoor residual spraying is not effective, or sustainable, particularly in the Bolivian Chaco region. The Bolivian National Chagas Control Program is seeking new approaches. This project aims is basic research to improve current vector control strategies, and to develop novel insecticide applications. The outcomes of these experiments will inform the Chagas Control Program about intervention options to reduce transmission to humans. Trypanosoma cruzi is a vector-borne parasitic disease of humans that causes chronic cardiac and gastrointestinal problems leading to death known as Chagas Disease (CD). It is transmitted by Triatomid bugs (vectors) and the important animal reservoir is domestic dogs. The highest incidence of CD is in the Bolivian Chaco, where control to reduce transmission is failing. This project will test the efficacy of registered systemic oral insecticides as a novel method to kill vectors that blood feed on treated dogs, similar to the use of oral Ivermectin insecticide to reduce worms in humans. Here dogs will be fed with insecticides and bioassays will be performed to determine bug’s mortality. The main aim is to reduce transmission of CD from the dog reservoir to humans.

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