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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Brain Researcharrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Brain Research
Article . 1981 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Brain Research
Article . 1981
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Effects of isoproterenol on the development of β-adrenergic receptors in brain cell aggregates

Authors: Barry Wolf; Damian H. Augustyn; Ronald E. Majocha; Mark D. Dibner; Perry B. Molinoff; Ross J. Baldessarini; Kenneth G. Walton;

Effects of isoproterenol on the development of β-adrenergic receptors in brain cell aggregates

Abstract

Abstract The development of binding sites for the β-adrenergic receptor antagonist [ 125 I]iodohydroxybenzylpindolol in reaggregate cultures of fetal rat brain has been investigated. β-Adrenergic receptor density increased rapidly between 6 and 22 days in culture at which time maximal density was attained. When cultures were grown in the presence of the β-adrenergic receptor agonist isoproterenol, the development of receptors was markedly inhibited. Cultures were also grown for 15 days in the presence of isoproterenol and then for 7–14 days in the absence of isoproterenol. Following the removal of the agonist, binding sites developed, but to only approximately 50% of the density seen in control cultures.

Subjects by Vocabulary

Microsoft Academic Graph classification: Agonist medicine.medical_specialty medicine.drug_class Brain Cell Internal medicine medicine Binding site Receptor Fetus Chemistry Receptor antagonist Rat brain Endocrinology β adrenergic receptor

Keywords

Culture Techniques, Receptors, Adrenergic, beta, Cyclic AMP, Animals, Molecular Biology, Binding Sites, General Neuroscience, Isoproterenol, Brain, Cell Differentiation, Rats, Receptors, Adrenergic, Neurology (clinical), Developmental Biology

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    16
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    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    16
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
    Powered byBIP!BIP!
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Average
Average
Top 10%
bronze
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