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NeuroImage
Article . 2013 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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NeuroImage
Article . 2012
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APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

Authors: J M, Rusted; S L, Evans; S L, King; N, Dowell; N, Tabet; P S, Tofts;

APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

Abstract

The APOE e4 allele, which confers an increased risk of developing dementia in older adulthood, has been associated with enhanced cognitive performance in younger adults. An objective of the current study was to compare task-related behavioural and neural signatures for e4 carriers (e4+) and non-e4 carriers (e4-) to help elucidate potential mechanisms behind such cognitive differences. On two measures of attention, we recorded clear behavioural advantages in young adult e4+ relative to e4-, suggesting that e4+ performed these tasks with a wider field of attention. Behavioural advantages were associated with increased task-related brain activations detected by fMRI (BOLD). In addition, behavioural measures correlated with structural measures derived from a former DTI analysis of white matter integrity in our cohort. These data provide clear support for an antagonistic pleiotropy hypothesis - that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age. The data implicate differences in both structural and functional signatures as complementary mediators of the behavioural advantage.

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Subjects by Vocabulary

Microsoft Academic Graph classification: Apolipoprotein E Brain mapping medicine Dementia Effects of sleep deprivation on cognitive performance Allele Young adult Antagonistic pleiotropy hypothesis Cognition medicine.disease Psychology Neuroscience

Keywords

Adult, Male, Heterozygote, Adolescent, Cognitive Neuroscience, Apolipoprotein E4, Polymorphism, Single Nucleotide, Young Adult, Image Interpretation, Computer-Assisted, Humans, Attention, Brain Mapping, Brain, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging, Neurology, Female

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    89
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
89
Top 10%
Top 10%
Top 1%
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