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Brain predictive coding processes are associated to COMT gene Val158Met polymorphism

Authors: Bonetti, L; Bruzzone, SEP; Sedghi, NA; Haumann, NT; Paunio, T; Kantojärvi, K; Kliuchko, M; +2 Authors

Brain predictive coding processes are associated to COMT gene Val158Met polymorphism

Abstract

Predicting events in the ever-changing environment is a fundamental survival function intrinsic to the physiology of sensory systems, whose efficiency varies among the population. Even though it is established that a major source of such variations is genetic heritage, there are no studies tracking down auditory predicting processes to genetic mutations. Thus, we examined the neurophysiological responses to deviant stimuli recorded with magnetoencephalography (MEG) in 108 healthy participants carrying different variants of Val158Met single-nucleotide polymorphism (SNP) within the catechol-O-methyltransferase (COMT) gene, responsible for the majority of catecholamines degradation in the prefrontal cortex. Our results showed significant amplitude enhancement of prediction error responses originating from the inferior frontal gyrus, superior and middle temporal cortices in heterozygous genotype carriers (Val/Met) vs homozygous (Val/Val and Met/Met) carriers. Integrating neurophysiology and genetics, this study shows how the neural mechanisms underlying optimal deviant detection vary according to the gene-determined cathecolamine levels in the brain. Peer reviewed

Countries
United Kingdom, Finland
Subjects by Vocabulary

Microsoft Academic Graph classification: Polymorphism (computer science) Prefrontal cortex education.field_of_study medicine.diagnostic_test Sensory memory Population Inferior frontal gyrus Sensory system Biology medicine education Catechol-O-methyl transferase Magnetoencephalography Neuroscience

Keywords

Male, Predictive coding, PREFRONTAL CORTEX, 3124 Neurology and psychiatry, Methionine, PARKINSONS-DISEASE, Magnetoencephalography (MEG), ENZYME-ACTIVITY, VAL(158)MET GENOTYPE, Brain, Magnetoencephalography, Valine, Magnetic Resonance Imaging, Neurology, Female, MESSENGER-RNA, RC321-571, Adult, Catechol-O-methyltransferase (COMT) gene, MISMATCH NEGATIVITY MMN, Cognitive Neuroscience, Neurosciences. Biological psychiatry. Neuropsychiatry, DOPAMINE TRANSPORTER, Catechol O-Methyltransferase, Polymorphism, Single Nucleotide, Humans, SENSORY MEMORY, COGNITIVE FUNCTION, CATECHOL-O-METHYLTRANSFERASE, Mismatch negativity (MMN), Forecasting

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Top 10%
gold
Related to Research communities
Neuroinformatics
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