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Publication . Article . 2020

Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer's disease spectrum

Meret Herdick; Martin Dyrba; Hans-Christian J. Fritz; Slawek Altenstein; Tommaso Ballarini; Frederic Brosseron; Katharina Buerger; +29 Authors
Open Access
Published: 01 Nov 2020
Publisher: Elsevier BV
Country: Spain
Abstract
Background: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer's disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and volume across the spectrum of AD. We further assessed effects of amyloid pathology on these changes. Methods: Participants included healthy controls, and subjects with subjective cognitive decline (SCD), mild cognitive impairment (MCI), or AD dementia (ADD) from the multicenter DELCODE study. Resting-state functional MRI (rs-fMRI) and structural MRI data was available for 477 subjects, and a subset of 243 subjects also had DTI data available. Differences between diagnostic groups were investigated using seed-based FC, volumetric, and MD analyses of functionally defined anterior (a-cBF) and posterior (p-cBF) subdivisions of a cytoarchitectonic cBF region-of-interest. In complementary analyses groups were stratified according to amyloid status based on CSF Aβ42/40 biomarker data, which was available in a subset of participants. Results: a-cBF and p-cBF subdivisions showed regional FC profiles that were highly consistent with previously reported patterns, but there were only minimal differences between diagnostic groups. Compared to controls, cBF volumes and MD were significantly different in MCI and ADD but not in SCD. The Aβ42/40 stratified analyses largely matched these results. Conclusions: We reproduced subregion-specific FC profiles of the cBF in a clinical sample spanning the AD spectrum. At least in this multicentric cohort study, cBF-FC did not show marked changes along the AD spectrum, and multimodal MRI did not provide more sensitive measures of AD-related cBF changes compared to volumetry.
Michel J. Grothe is supported by the “Miguel Servet” program [CP19/00031] of the Spanish Instituto de Salud Carlos III (ISCIIIFEDER).
Subjects by Vocabulary

Medical Subject Headings: nervous system circulatory and respiratory physiology sense organs skin and connective tissue diseases cardiovascular system

Microsoft Academic Graph classification: Medicine business.industry business Cohort study Internal medicine medicine.medical_specialty Cognitive decline Resting state fMRI Biomarker (medicine) Cholinergic Amyloid Dementia medicine.disease Cardiology Basal forebrain

Library of Congress Subject Headings: lcsh:Computer applications to medicine. Medical informatics lcsh:R858-859.7 lcsh:Neurology. Diseases of the nervous system lcsh:RC346-429

Subjects

Cholinergic Basal Forebrain, Subjective Cognitive Decline, Alzheimer’s Disease, Functional Connectivity, Mean Diffusivity, Resting-state fMRI, Cognitive Neuroscience, Neurology (clinical), Neurology, Radiology, Nuclear Medicine and imaging, Cholinergic Basal Forebrain, Subjective Cognitive Decline, Alzheimer’s Disease, Functional Connectivity, Mean Diffusivity, Resting-state fMRI, Regular Article, AD, Alzheimer’s Disease, cBF, cholinergic basal forebrain, dACC, dorsal anterior cingulate, DTI, diffusion tensor imaging, FC, functional connectivity, GM, gray matter, MCI, mild cognitive impairment, MD, mean diffusity, NBM, nucleus basilis of Meynert, SCD, subjective cognitive decline, WM, white matter

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