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Other literature type . 2020
Data sources: PubMed Central
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Trends in Neurosciences
Article . 2020 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Circuit-Based Biomarkers for Mood and Anxiety Disorders

Authors: Xia, Frances; Kheirbek, Mazen A.;

Circuit-Based Biomarkers for Mood and Anxiety Disorders

Abstract

Mood and anxiety disorders are complex heterogeneous syndromes that manifest in dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain-wide activity patterns in humans have proven useful in distinguishing between disorder subtypes and identifying effective treatments. In order to improve biomarker identification, it is crucial to understand the basic circuitry underpinning brain-wide activity patterns. Leveraging a large repertoire of techniques, animal studies have examined roles of specific cell types and circuits in driving maladaptive behavior. Recent advances in multiregion recording techniques, data-driven analysis approaches, and machine-learning-based behavioral analysis tools can further push the boundary of animal studies and bridge the gap with human studies, to assess how brain-wide activity patterns encode and drive emotional behavior. Together, these efforts will allow identifying more precise biomarkers to enhance diagnosis and treatment.

Country
United States
Subjects by Vocabulary

Microsoft Academic Graph classification: Biomarker identification ENCODE medicine Human studies Behavioral analysis Mood Emotional behavior Anxiety Biomarker (medicine) medicine.symptom Psychology Neuroscience

Keywords

multiregion recording, Biological Psychology, Anxiety, Basic Behavioral and Social Science, Article, Clinical and health psychology, Behavioral and Social Science, Psychology, Animals, Humans, data-driven analysis, Neurology & Neurosurgery, Biomedical and Clinical Sciences, Mood Disorders, General Neuroscience, Neurosciences, reverse translation, Brain, Anxiety Disorders, Brain Disorders, Affect, Mental Health, Neurological, biomarker, circuit manipulation, Cognitive Sciences, Mind and Body, Biomarkers

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    28
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    28
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
    Powered byBIP!BIP!
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
28
Top 10%
Average
Top 10%
Green
bronze
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
Related to Research communities
Neuroinformatics
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