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Publication . Article . 2016

Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model

Roman Gersner; Sameer C. Dhamne; Abraham Zangen; Alvaro Pascual-Leone; Alexander Rotenberg;
Open Access
Published: 01 Sep 2016 Journal: Epilepsy & Behavior, volume 62, pages 136-139 (issn: 1525-5050, Copyright policy )
Publisher: Elsevier BV
Abstract Background Status epilepticus (SE) is a condition of prolonged or recurrent and often drug-resistant seizures where nonsedating SE therapy remains an important unmet need. Repetitive transcranial magnetic stimulation (rTMS) is emerging as a means to suppress seizures but has not been extensively studied in models. Objectives We aimed to test the antiepileptic potential of high-frequency rTMS in SE. As a step toward eventual coupling of rTMS with antiepileptic pharmacotherapy, we also tested whether high-frequency rTMS in combination with a low (ineffective but less likely to cause a side effect) lorazepam dose is as effective as a full lorazepam dose in suppressing seizures in a rat SE model. Methods EEG was recorded to measure epileptic spike frequency in the rat kainate SE model. Epileptic spikes were counted before, during, and after either high-frequency rTMS treatment alone or high-frequency rTMS treatment in combination with lorazepam, a firstline SE treatment. Results We found that rTMS alone decreases epileptic spike frequency only acutely. However, combinatory treatment with half-dose lorazepam together with rTMS was as effective as a full lorazepam dose. Conclusion We report that high-frequency rTMS has modest antiepileptic potential alone but acts in complement with lorazepam to suppress seizures.
Subjects by Vocabulary

Microsoft Academic Graph classification: Transcranial magnetic stimulation medicine.medical_treatment medicine Anesthesia Lorazepam medicine.drug Kainate receptor Epilepsy medicine.disease Pharmacotherapy Side effect Status epilepticus medicine.symptom Electroencephalography medicine.diagnostic_test business.industry business

Medical Subject Headings: mental disorders nervous system behavioral disciplines and activities


Behavioral Neuroscience, Neurology (clinical), Neurology

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