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Nature Communications
Article
License: CC BY
Data sources: UnpayWall
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Nature Communications
Article . 2015 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
Hyper Article en Ligne; Hal-Diderot
Other literature type . Article . 2015
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Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion

Authors: Alexis Saintamand; Pauline Rouaud; Faten Saad; Géraldine Rios; Michel Cogné; Yves Denizot;

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletion

Abstract

International audience; In mature B cells, class switch recombination (CSR) replaces the expressed constant Cμ gene with a downstream C(H) gene. How the four transcriptional enhancers of the IgH 3' regulatory region (3'RR) control CSR remains an open question. We have investigated IgG1 CSR in 3'RR-deficient mice. Here we show that the 3'RR enhancers target the S(γ1) acceptor region (and poorly the S(μ) donor region) by acting on epigenetic marks, germline transcription, paused RNA Pol II recruitment, R loop formation, AID targeting and double-strand break generation. In contrast, location and diversity of S(μ)-S(γ1) junctions are not affected by deletion of the 3'RR enhancers. Thus, the 3'RR controls the first steps of CSR by priming the S acceptor region but is not implicated in the choice of the end-joining pathway.

Country
France
Subjects by Vocabulary

Microsoft Academic Graph classification: Biology Prime (order theory) Regulatory region Germline Enhancer Genetics Immunoglobulin class switching

Keywords

Male, [SDV.IMM] Life Sciences [q-bio]/Immunology, General Physics and Astronomy, Regulatory Sequences, Nucleic Acid, General Biochemistry, Genetics and Molecular Biology, Epigenesis, Genetic, Mice, Animals, Cloning, Molecular, Multidisciplinary, General Chemistry, Recombinant Proteins, Immunoglobulin Switch Region, Immunoglobulin G, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Immunoglobulin Heavy Chains, Spleen

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    61
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
61
Top 10%
Top 10%
Top 10%
gold