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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

large-scale proof of concept
Authors: Franke, Barbara; Stein, Jason L; McIntosh, Andrew M; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; +287 Authors

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

peerReviewed

final draft

Article

Countries
Italy, Netherlands, Ireland, Netherlands, Netherlands, United Kingdom, United Kingdom, Italy, Germany, France, United Kingdom, United Kingdom, Netherlands, United States, Germany, Finland, Netherlands, Netherlands, Netherlands, Finland, Netherlands, Netherlands, Australia
Subjects by Vocabulary

Microsoft Academic Graph classification: Genome-wide association study Meta-analysis Psychology Schizophrenia (object-oriented programming) Brain Structure and Function Neuroimaging Genetic architecture Genetic marker Endophenotype Neuroscience

Dewey Decimal Classification: ddc:570

Keywords

Netherlands Twin Register (NTR), genetic association, Biological Psychology, brain imaging, VARIANTS, Genome-wide association studies, Linkage Disequilibrium, pathology [Brain], GWAS, Psychology, 2.1 Biological and endogenous factors, genetics [Schizophrenia], genetics [Genetic Predisposition to Disease], Aetiology, Non-U.S. Gov't, PERSPECTIVE, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Research Support, Non-U.S. Gov't, General Neuroscience, Brain, Pharmacology and Pharmaceutical Sciences, Organ Size, Single Nucleotide, Brain; Endophenotypes; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Magnetic Resonance Imaging; Neuroimaging; Organ Size; Polymorphism, Single Nucleotide; Schizophrenia; Genome-Wide Association Study; Neuroscience (all), Serious Mental Illness, ENIGMA Consortium, Magnetic Resonance Imaging, endophenotype, Mental Health, Neurological, genetics [Polymorphism, Single Nucleotide], Cognitive Sciences, MRI, Neuroinformatics, heredity, Endophenotypes, DISORDERS, Brain, Endophenotypes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Magnetic Resonance Imaging, Neuroimaging, Organ Size, Polymorphism, Single Nucleotide, Schizophrenia, Non-P.H.S., RELATIVES, Neuroimaging, PHENOTYPES, Research Support, Polymorphism, Single Nucleotide, N.I.H., ENDOPHENOTYPE, Research Support, N.I.H., Extramural, Journal Article, /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, GENOME-WIDE ASSOCIATION, pathology [Schizophrenia], METAANALYSIS, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Neuroscience (all), Neurology & Neurosurgery, Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience, Biomedical and Clinical Sciences, [SCCO.NEUR]Cognitive science/Neuroscience, Human Genome, Neurosciences, Extramural, Brain Disorders, meta-analysis, INDIVIDUALS, DISCOVERY, Schizophrenia, Genetic markers, U.S. Gov't, genetic predisposition, Research Support, U.S. Gov't, Non-P.H.S., Meta-Analysis, Genome-Wide Association Study

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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