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Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo

Authors: Szabó, Zsolt; Héja, László; Szalay, Gergely; Kékesi, Orsolya; Füredi, András; Szebényi, Kornélia; Dobolyi, Árpád; +8 Authors

Extensive astrocyte synchronization advances neuronal coupling in slow wave activity in vivo

Abstract

AbstractSlow wave activity (SWA) is a characteristic brain oscillation in sleep and quiet wakefulness. Although the cell types contributing to SWA genesis are not yet identified, the principal role of neurons in the emergence of this essential cognitive mechanism has not been questioned. To address the possibility of astrocytic involvement in SWA, we used a transgenic rat line expressing a calcium sensitive fluorescent protein in both astrocytes and interneurons and simultaneously imaged astrocytic and neuronal activityin vivo. Here we demonstrate, for the first time, that the astrocyte network display synchronized recurrent activityin vivocoupled to UP states measured by field recording and neuronal calcium imaging. Furthermore, we present evidence that extensive synchronization of the astrocytic network precedes the spatial build-up of neuronal synchronization. The earlier extensive recruitment of astrocytes in the synchronized activity is reinforced by the observation that neurons surrounded by active astrocytes are more likely to join SWA, suggesting causality. Further supporting this notion, we demonstrate that blockade of astrocytic gap junctional communication or inhibition of astrocytic Ca2+transients reduces the ratio of both astrocytes and neurons involved in SWA. Thesein vivofindings conclusively suggest a causal role of the astrocytic syncytium in SWA generation.

Country
Hungary
Subjects by Vocabulary

Microsoft Academic Graph classification: Cell type Biology Calcium imaging In vivo Cellular neuroscience medicine Premovement neuronal activity Syncytium Coupling (electronics) medicine.anatomical_structure Neuroscience Astrocyte

Keywords

Male, Science, Gene Expression, Cell Communication, Article, Membrane Potentials, Interneurons, Animals, Calcium Signaling, Anesthetics, Neurons, Multidisciplinary, Q, R, Brain, Gap Junctions, Brain Waves, Rats, Astrocytes, Medicine, Female, Rats, Transgenic, Biomarkers, Signal Transduction

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    64
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
64
Top 10%
Average
Top 10%
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gold
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EC| VISONby3DSTIM
Project
VISONby3DSTIM
Restoration of visual perception by artificial stimulation performed by 3D EAO microscopy
  • Funder: European Commission (EC)
  • Project Code: 682426
  • Funding stream: H2020 | ERC | ERC-COG
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