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British Journal Of Nutrition
Article . 1997 . Peer-reviewed
License: Cambridge Core User Agreement
Data sources: Crossref
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Tissue localization of threonine oxidation in pigs

Authors: Le Floc'h, Nathalie; Thibault, Jean-Noel,; Sève, Bernard;

Tissue localization of threonine oxidation in pigs

Abstract

Two experiments were designed to determine the tissue distribution of threonine oxidation through the threonine dehydrogenase (EC1.1.1.103) pathway in pigs. The first experiment was conducted on eleven Piétrain x Large White piglets. The piglets were slaughtered at 5, 12 or 20 kg after 1 h of infusion with L-[U-14C]threonine (55 kBq/kg) mixed with unlabelled threonine (100 mg/kg). In the second experiment, four Piétrain x Large White and four Large White piglets (10 kg body weight) were infused with L-[1-13C]threonine (50 mg'kg) mixed with 50 mg'kg unlabelled threonine for 1 h, then killed for tissue sampling. In the two experiments, threonine dehydrogenase specific activity and threonine and glycine specific radioactivities and enrichments were measured in several tissues and in plasma. The higher level of labelling of threonine in the pancreas than in the liver suggested either a lower protein degradation rate or a faster rate of threonine transport in the liver than in the pancreas. Threonine dehydrogenase activity was found only in the liver and the pancreas. Whereas liver and pancreas threonine dehydrogenase specific activities were similar, glycine specific radioactivity and enrichment were 12- to 14-fold higher in the pancreas than in the liver. This is probably the consequence of a higher production rate of glycine from sources other than threonine (protein degradation,de novosynthesis from serine) in the liver than in the pancreas. Our results showed that Large White pigs could oxidize more threonine than Piétrain x Large White pigs. This could be related to the difference in growth performance and dietary N efficiency for protein deposition between these two genotypes.

Country
France
Related Organizations
Subjects by Vocabulary

Microsoft Academic Graph classification: Biology Protein degradation Threonine transport Serine Blood plasma Threonine chemistry.chemical_classification Amino acid chemistry Biochemistry Glycine Specific activity

Keywords

Threonine, Genotype, Swine, [SDV]Life Sciences [q-bio], Glycine, Medicine (miscellaneous), Gas Chromatography-Mass Spectrometry, Animals, Carbon Radioisotopes, Pancreas, Analysis of Variance, Nutrition and Dietetics, Body Weight, [SDV] Life Sciences [q-bio], Alcohol Oxidoreductases, Liver, Female, Oxidation-Reduction

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    impulse
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    Average
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    34
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
34
Average
Top 10%
Average
bronze
Related to Research communities
Neuroinformatics
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