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Europe PubMed Central
Article . 1987
Data sources: PubMed Central
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The Journal of Cell Biology
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The Journal of Cell Biology
Article . 1987 . Peer-reviewed
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The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

Authors: James L. Salzer; WP Holmes; Colman;

The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily

Abstract

The myelin associated glycoproteins (MAG) are integral plasma membrane proteins which are found in oligodendrocytes and Schwann cells and are believed to mediate the axonal-glial interactions of myelination. In this paper we demonstrate the existence in central nervous system myelin of two MAG polypeptides with Mrs of 67,000 and 72,000 that we have designated small MAG (S-MAG) and large MAG (L-MAG), respectively. The complete amino acid sequence of L-MAG and a partial amino acid sequence of S-MAG have been deduced from the nucleotide sequences of corresponding cDNA clones isolated from a lambda gt11 rat brain expression library. Based on their amino acid sequences, we predict that both proteins have an identical membrane spanning segment and a large extracellular domain. The putative extracellular region contains an Arg-Gly-Asp sequence that may be involved in the interaction of these proteins with the axon. The extracellular portion of L-MAG also contains five segments of internal homology that resemble immunoglobulin domains, and are strikingly homologous to similar domains of the neural cell adhesion molecule and other members of the immunoglobulin gene superfamily. In addition, the two MAG proteins differ in the extent of their cytoplasmically disposed segments and appear to be the products of alternatively spliced mRNAs. Of considerable interest is the finding that the cytoplasmic domain of L-MAG, but not of S-MAG, contains an amino acid sequence that resembles the autophosphorylation site of the epidermal growth factor receptor.

Subjects by Vocabulary

Microsoft Academic Graph classification: Immunoglobulin gene Immunoglobulin domain Biology Peptide sequence chemistry.chemical_classification Nucleic acid sequence Amino acid Membrane protein Biochemistry chemistry Immunoglobulin superfamily Glycoprotein

Keywords

Transcription, Genetic, Immunoglobulins, Sequence Homology, Nucleic Acid, Animals, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Base Sequence, Brain, Articles, DNA, DNA Restriction Enzymes, Cell Biology, Rats, Molecular Weight, Myelin-Associated Glycoprotein, Genes, Myelin Proteins

66 references, page 1 of 7

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2. Bankik, N. L., and M. E. Smith. 1977. Protein determinants ofmyelination in different regions of developing rat central nervous system. Biochem. J. 162:247-255.

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6. Dayhoff, M. O., W. C. Barker, and L. T. Hunt. 1983. Establishing homologies in protein sequences. Methods Enzymol. 91:524-545.

7. Dillon, J. R., A. Nasim, and E. R. Nestmarm, editors. 1985. Recombinant DNA Methodology. John Wiley & Sons, Inc., New York. 219.

8. Downward, J., P. Parker, and M. D. Waterfield. 1984. Autophosphorylation sites on the epidermal growth factor receptor. Nature (Lond.). 311:483--485.

9. Edelman, G. M. 1984. Modulation of cell adhesion during induction, histogenesis, and perinatal development of the nervous system. Anna. Rev. Neurosci. 7:339-377.

10. Frail, D. E., and P. E. Braun. 1984. Two developmentally regulated messenger RNAs differing in their coding region may exist for the myelinassociated glycoprotein. J. Biol. Chem. 259:14857-14862.

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    423
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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
423
Top 10%
Top 1%
Top 0.1%
Green
hybrid
Funded by
NIH| BIOSYNTHESIS AND ASSEMBLY OF MYELIN MEMBRANE PROTEINS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01NS020147-16S1
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
,
NIH| THE MYELIN ASSOCIATED GLYCOPROTEIN
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5K07NS000905-03
  • Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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