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The Journals of Gerontology Series A
Article . 2003 . Peer-reviewed
Data sources: Crossref
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Carnitine: A Neuromodulator in Aged Rats

Authors: Packiasamy A R, Juliet; Deepak, Balasubramaniam; Naveen, Balasubramaniam; Chinnakannu, Panneerselvam;

Carnitine: A Neuromodulator in Aged Rats

Abstract

A wide range of morphological and biochemical changes occur in the central nervous system with increasing age. L-carnitine, a naturally occurring compound, plays a vital role in fatty acid transport across the mitochondrial membrane. L-carnitine (300 mg/kg body wt/day) was administered intraperitoneally to young and old male Wistar rats for 7, 14, and 21 days. Carnitine, dopamine, epinephrine, and serotonin levels were assayed in discrete regions of the brain. Carnitine supplementation increased the levels of dopamine, epinephrine, and serotonin in the experimental animals in our study. Response to carnitine supplementation varied among the brain regions that have been studied. The regions rich in cholinergic neurons such as the cortex, hippocampus, and striatum showed more response after 21 days of carnitine treatment. The results of the present study suggest the role of L-carnitine as a neuromodulator and antiaging medication.

Related Organizations
Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.medical_specialty Central nervous system Hippocampus Striatum Biology Dopamine Internal medicine medicine Carnitine Cholinergic neuron medicine.anatomical_structure Endocrinology Epinephrine Serotonin medicine.drug

Keywords

Male, Serotonin, Aging, Epinephrine, Dopamine, Carnitine, Animals, Tissue Distribution, Neurotransmitter Agents, Brain, Rats, Geriatrics and Gerontology

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    29
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Average
Top 10%
Average
bronze
Related to Research communities
Neuroinformatics