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Europe PubMed Central
Article . 2012
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Article . 2013
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The Journal of Infectious Diseases
Article . 2012 . Peer-reviewed
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Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection

Authors: Kévin P. Dhondt; Cyrille Mathieu; Marie Chalons; Joséphine M. Reynaud; Audrey Vallve; Hervé Raoul; Branka Horvat;

Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection

Abstract

International audience; Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are resistant to henipavirus infection. We report here the susceptibility of mice deleted for the type I interferon receptor (IFNAR-KO) to both HeV and NiV. Intraperitoneally infected mice developed fatal encephalitis, with pathology and immunohistochemical features similar to what was found in humans. Viral RNA was found in the majority of analyzed organs, and sublethally infected animals developed virus-specific neutralizing antibodies. Altogether, these results reveal IFNAR-KO mice as a new small animal model to study HeV and NiV pathogenesis, prophylaxis, and treatment and suggest the critical role of type I interferon signaling in the control of henipavirus infection.

Country
France
Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.disease_cause Hepatitis E virus Interferon biology Encephalitis Henipavirus medicine.drug Viral entry medicine Hendra Virus biology.organism_classification medicine.disease Virology Viral replication Interferon type I

Keywords

MESH: Signal Transduction, MESH: Interferon Type I, encephalitis, MESH: Virus Internalization, [SDV]Life Sciences [q-bio], MESH: Henipavirus Infections, Nipah virus, MESH: Virulence, Antibodies, Viral, Virus Replication, MESH: Mice, Knockout, MESH: Antibodies, Neutralizing, MESH: Hendra Virus, Mice, Antibody Specificity, Immunology and Allergy, MESH: Animals, Encephalitis, Viral, MESH: Nipah Virus, Cells, Cultured, Henipavirus Infections, Mice, Knockout, Virulence, Brain, MESH: Encephalitis, Viral, Infectious Diseases, MESH: Survival Analysis, MESH: RNA, Viral, Interferon Type I, Viruses, RNA, Viral, type I interferon, MESH: Neuroglia, Neuroglia, Signal Transduction, MESH: Cells, Cultured, MESH: Henipavirus, Hendra Virus, Major Articles and Brief Reports, MESH: Brain, Animals, Humans, MESH: Antibody Specificity, MESH: Mice, Henipavirus, MESH: Humans, animal model, MESH: Virus Replication, Virus Internalization, Antibodies, Neutralizing, Survival Analysis, Disease Models, Animal, MESH: Disease Models, Animal, MESH: Antibodies, Viral

45 references, page 1 of 5

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    59
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
59
Top 10%
Top 10%
Top 10%
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