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Article . 2021
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Journal of Neuroscience Methods
Article . 2021
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Estimation of Laminar BOLD Activation Profiles using Deconvolution with a Physiological Point Spread Function

Authors: Markuerkiaga, I.; Marques, J.P.; Gallagher, Tara E.; Norris, D.G.; Norris, D.G.;

Estimation of Laminar BOLD Activation Profiles using Deconvolution with a Physiological Point Spread Function

Abstract

AbstractBackgroundThe specificity of gradient echo (GE)-BOLD laminar fMRI activation profiles is degraded by intracortical veins that drain blood from lower to upper cortical layers, propagating activation signal in the same direction. This work describes an approach to obtain layer specific profiles by deconvolving the measured profiles with a physiological Point Spread Function (PSF).New MethodIt is shown that the PSF can be characterised by a TE-dependent peak to tail (p2t) value that is independent of cortical depth and can be estimated by simulation. An experimental estimation of individual p2t values and the sensitivity of the deconvolved profiles to variations in p2t is obtained using laminar data measured with a multi-echo 3D-FLASH sequence. These profiles are echo time dependent, but the underlying neuronal response is the same, allowing a data-based estimation of the PSF.ResultsThe deconvolved profiles are highly similar to the gold-standard obtained from extremely high resolution 3D-EPI data, for a range of p2t values of 5-9, which covers both the empirically determined value (7.1) and the value obtained by simulation (6.3).Comparison with Existing Method(s)Corrected profiles show a flatter shape across the cortex and a high level of similarity with the gold-standard, defined as a subset of profiles that are unaffected by intracortical veins.ConclusionsWe conclude that deconvolution is a robust approach for removing the effect of signal propagation through intracortical veins. This makes it possible to obtain profiles with high laminar specificity while benefitting from the higher sensitivity and efficiency of GE-BOLD sequences.

Country
Netherlands
Subjects by Vocabulary

Microsoft Academic Graph classification: Point spread function Physics Similarity (geometry) Laminar flow Signal Range (statistics) Sensitivity (control systems) Deconvolution Biological system Gradient echo

Keywords

Brain Mapping, General Neuroscience, Medizin, Magnetic Resonance Imaging, 150 000 MR Techniques in Brain Function, Computer Simulation, 320 000 MR Structural Quantitative Imaging

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    13
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    13
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
    Powered byBIP!BIP!
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Top 10%
Average
Top 10%
Green
hybrid
Funded by
EC| HIMR
Project
HIMR
Ultra-High Field Magnetic Resonance Imaging
  • Funder: European Commission (EC)
  • Project Code: 316716
  • Funding stream: FP7 | SP3 | PEOPLE
Related to Research communities
Neuroinformatics
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