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Publication . Article . 2015

Effects of a 60 Hz Magnetic Field Exposure Up to 3000 μT on Human Brain Activation as Measured by Functional Magnetic Resonance Imaging

Alexandre Legros; Julien Modolo; Samantha Brown; John Roberston; Alex W. Thomas;
Open Access
English
Published: 27 Jul 2015
Publisher: HAL CCSD
Country: France
Abstract
International audience; Several aspects of the human nervous system and associated motor and cognitive processes have been reported to be modulated by extremely low-frequency (ELF, < 300 Hz) time-varying Magnetic Fields (MF). Due do their worldwide prevalence; power-line frequencies (60 Hz in North America) are of particular interest. Despite intense research efforts over the last few decades, the potential effects of 60 Hz MF still need to be elucidated, and the underlying mechanisms to be understood. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to characterize potential changes in functional brain activation following human exposure to a 60 Hz MF through motor and cognitive tasks. First, pilot results acquired in a first set of subjects (N=9) were used to demonstrate the technical feasibility of using fMRI to detect subtle changes in functional brain activation with 60 Hz MF exposure at 1800 μT. Second, a full study involving a larger cohort of subjects tested brain activation during 1) a finger tapping task (N=20), and 2) a mental rotation task (N=21); before and after a one-hour, 60 Hz, 3000 μT MF exposure. The results indicate significant changes in task-induced functional brain activation as a consequence of MF exposure. However, no impact on task performance was found. These results illustrate the potential of using fMRI to identify MF-induced changes in functional brain activation, suggesting that a one-hour 60 Hz, 3000 μT MF exposure can modulate activity in specific brain regions after the end of the exposure period (i.e., residual effects). We discuss the possibility that MF exposure at 60 Hz, 3000 μT may be capable of modulating cortical excitability via a modulation of synaptic plasticity processes.
Subjects by Vocabulary

ACM Computing Classification System: ComputingMilieux_MISCELLANEOUS

Microsoft Academic Graph classification: Magnetic resonance imaging medicine.diagnostic_test medicine Brain mapping Finger tapping Neuroscience Human brain medicine.anatomical_structure Functional magnetic resonance imaging Mental rotation business.industry business Elementary cognitive task Nervous system

Library of Congress Subject Headings: lcsh:Medicine lcsh:R lcsh:Science lcsh:Q

Subjects

[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SCCO.NEUR]Cognitive science/Neuroscience, Multidisciplinary, Research Article

73 references, page 1 of 8

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Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
Related to Research communities
Neuroinformatics
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Article . 2015
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