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Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning

Authors: Andreas Berg Storsve; Anders M. Fjell; Anastasia Yendiki; Kristine B. Walhovd;

Longitudinal Changes in White Matter Tract Integrity across the Adult Lifespan and Its Relation to Cortical Thinning

Abstract

A causal link between decreases in white matter (WM) integrity and cortical degeneration is assumed, but there is scarce knowledge on the relationship between these changes across the adult human lifespan. We investigated changes in thickness throughout the cortical mantle and WM tract integrity derived from T1 and diffusion weighted magnetic resonance imaging (MRI) scans in 201 healthy adults aged 23-87 years over a mean interval of 3.6 years. Fractional anisotropy (FA), mean (MD), radial (RD) and axial (AD) diffusivity changes were calculated for forceps minor and major and eight major white matter tracts in each hemisphere by use of a novel automated longitudinal tractography constrained by underlying anatomy (TRACULA) approach. We hypothesized that increasing MD and decreasing FA across tracts would relate to cortical thinning, with some anatomical specificity. WM integrity decreased across tracts non-uniformly, with mean annual percentage decreases ranging from 0.20 in the Inferior Longitudinal Fasciculus to 0.65 in the Superior Longitudinal Fasciculus. For most tracts, greater MD increases and FA decreases related to more cortical thinning, in areas in part overlapping with but also outside the projected tract endings. The findings indicate a combination of global and tract-specific relationships between WM integrity and cortical thinning.

Subjects by Vocabulary

Microsoft Academic Graph classification: Pathology Cortical thinning medicine.diagnostic_test Superior longitudinal fasciculus medicine.anatomical_structure Tractography medicine.medical_specialty Lateralization of brain function White matter Fractional anisotropy medicine Inferior longitudinal fasciculus business.industry Magnetic resonance imaging business

Library of Congress Subject Headings: lcsh:Medicine lcsh:Science lcsh:R lcsh:Q

Keywords

Male, Central Nervous System, Nervous System, Diagnostic Radiology, Animal Cells, Materials Physics, Medicine and Health Sciences, Longitudinal Studies, Right Hemisphere, Microstructure, Aged, 80 and over, Cerebral Cortex, Multidisciplinary, Radiology and Imaging, Physics, Brain, Neurodegenerative Diseases, Middle Aged, White Matter, Magnetic Resonance Imaging, Neurology, Physical Sciences, Female, Cellular Types, Anatomy, Research Article, Adult, Imaging Techniques, Immune Cells, Immunology, Materials Science, Antigen-Presenting Cells, Research and Analysis Methods, Young Adult, Diagnostic Medicine, Alzheimer Disease, Mental Health and Psychiatry, Humans, Adults, Left Hemisphere, Aged, Biology and Life Sciences, Cell Biology, Diffusion Magnetic Resonance Imaging, Age Groups, People and Places, Anisotropy, Dementia, Population Groupings, Cerebral Hemispheres

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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
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    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    51
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
51
Top 10%
Average
Top 10%
Green
gold
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NIH| Center for Functional Imaging Technologies
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P41EB015896-18
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
,
NIH| A Storage Area Network for Structural and Functional Image Analysis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1S10RR023401-01A2
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES
iis
,
EC| NEUROCOGPLASTICITY
Project
NEUROCOGPLASTICITY
Neurocognitive Plasticity – Lifespan Mechanisms of Change
  • Funder: European Commission (EC)
  • Project Code: 313440
  • Funding stream: FP7 | SP2 | ERC
Validated by funder | iis
,
NIH| The Human Connectome Project (HCP)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01MH093765-02
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
iis
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