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Paradoxical relationship between body mass index and bone mineral density in patients with non–small cell lung cancer with brain metastasis

Authors: Nam, Min Woo; Kim, Jae Min; Cheong, Jin Hwan; Ryu, Je Il; Han, Myung-Hoon;

Paradoxical relationship between body mass index and bone mineral density in patients with non–small cell lung cancer with brain metastasis

Abstract

Background and purposeLow body mass index (BMI) at presentation has been reported to be associated with higher incidence and mortality of lung cancer, but studies on the relationship between brain metastasis and BMI at presentation are lacking. This study aimed to evaluate the association between brain metastasis and BMI and bone mineral density (BMD) in NSCLC.MethodsWe retrospectively enrolled patients with non-small cell lung cancer who underwent brain magnetic resonance imaging with contrast within 3 months of diagnosis. The BMI was collected, and the BMD was measured in Hounsfield unit (HU) on initial staging computed tomography scans. The independent relationship between BMI and BMD was assessed using multivariable linear regression according to the presence of brain metastasis.ResultsA total of 356 consecutive NSCLC patients were enrolled in the study over a 8-year period in a single institution. Lower BMI with higher BMD was an independent predictive factor for brain metastasis in patients with NSCLC, relative to the other group (HR, 2.03; 95% CI, 1.21 to 3.40; P = 0.007). We also found a significant negative correlation between BMI and BMD among patients with NSCLC with brain metastases (B, -3.343; 95% confidence interval, -6.352 to -0.333; P = 0.030).ConclusionsBrain metastasis may possibly be associated with lower BMI and higher BMD in NSCLC patients. We expect that these results may facilitate future predictions of brain metastases during the clinical course of NSCLC and enhance our understanding of the underlying mechanisms that link brain metastases and lung cancer.

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Subjects by Vocabulary

Microsoft Academic Graph classification: Oncology Bone density Bone mineral medicine.diagnostic_test medicine.medical_specialty Breast cancer Internal medicine medicine Carcinoma Lung cancer business.industry Magnetic resonance imaging medicine.disease business Body mass index Brain metastasis

Keywords

Male, Lung Neoplasms, Physiology, Lung and Intrathoracic Tumors, Body Mass Index, Diagnostic Radiology, Cell Signaling, Bone Density, Carcinoma, Non-Small-Cell Lung, Medicine and Health Sciences, Neurological Tumors, Tomography, WNT Signaling Cascade, Aged, 80 and over, Multidisciplinary, Brain Neoplasms, Radiology and Imaging, Q, R, Brain, Middle Aged, Magnetic Resonance Imaging, Signaling Cascades, Oncology, Neurology, Physiological Parameters, Medicine, Female, Research Article, Signal Transduction, Imaging Techniques, Science, Neuroimaging, Research and Analysis Methods, Diagnostic Medicine, Cancer Detection and Diagnosis, Humans, Aged, Neoplasm Staging, Retrospective Studies, Body Weight, Cancers and Neoplasms, Biology and Life Sciences, Cell Biology, Non-Small Cell Lung Cancer, Computed Axial Tomography, Brain Metastasis, Tomography, X-Ray Computed, Neuroscience

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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