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Europe PubMed Central
Other literature type . 2010
Data sources: PubMed Central
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Journal of Psychiatry and Neuroscience
Article . 2010 . Peer-reviewed
Data sources: Crossref
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Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression

Authors: Gerd, Wagner; Kathrin, Koch; Claudia, Schachtzabel; Thomas, Sobanski; Jürgen R, Reichenbach; Heinrich, Sauer; Ralf G M, Schlösser;

Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression

Abstract

We investigated the differential effects of serotonergic and noradrenergic antidepressants on brain activation in patients with major depressive disorder during a Stroop task. We predicted that pretreatment hyperactivity in the rostral anterior cingulate cortex would predict better treatment outcomes.In total, 20 patients underwent naturalistic open-label clinical treatment with citalopram (n = 12) or reboxetine (n = 8). We performed functional magnetic resonance imaging at baseline and after 6 weeks of treatment.There were no significant group differences in clinical characteristics, treatment outcomes or baseline fMRI activations. The group by time interaction revealed significant voxels in the right amygdala-hippocampus complex (p0.05, family-wise error corrected by use of the bilateral amygdala and hippocampus mask image as a small volume), indicating a posttreatment blood oxygen level- dependent signal decrease in the citalopram group. Pretreatment hyperactivity in the rostral anterior cingulate cortex was not related to symptom improvement.Our study was a nonrandomized clinical trial.These results indicate that serotonergic and noradrenergic antidepressants have a differential effect on brain activity, especially in the amygdala and hippocampus.

Subjects by Vocabulary

Microsoft Academic Graph classification: Brain activity and meditation Electroencephalography medicine.diagnostic_test Reboxetine medicine.anatomical_structure Major depressive disorder Psychology medicine.drug Citalopram Serotonergic medicine Anterior cingulate cortex medicine.disease Neuroscience Stroop effect

Keywords

Male, Neuropsychological Tests, Cognition, Image Processing, Computer-Assisted, Pharmacology (medical), Evoked Potentials, Adrenergic Uptake Inhibitors, Brain, Electroencephalography, Middle Aged, Magnetic Resonance Imaging, Psychiatry and Mental health, Treatment Outcome, Female, Selective Serotonin Reuptake Inhibitors, Research Paper, Adult, Adolescent, Morpholines, Citalopram, Reboxetine, Young Adult, Predictive Value of Tests, Humans, Biological Psychiatry, Psychiatric Status Rating Scales, Analysis of Variance, Depressive Disorder, Oxygen, Psychomotor Performance

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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    76
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
76
Top 10%
Top 10%
Top 10%
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gold
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