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Article . 2017
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Amyloid Network Topology Characterizes the Progression of Alzheimer’s Disease During the Predementia Stages

Authors: Joana B Pereira; Tor Olof Strandberg; Sebastian Palmqvist; Giovanni Volpe; Danielle van Westen; Eric Westman; Oskar Hansson;

Amyloid Network Topology Characterizes the Progression of Alzheimer’s Disease During the Predementia Stages

Abstract

Abstract There is increasing evidence showing that the accumulation of the amyloid-β (Aβ) peptide into extracellular plaques is a central event in Alzheimer's disease (AD). These abnormalities can be detected as lowered levels of Aβ42 in the cerebrospinal fluid (CSF) and are followed by increased amyloid burden on positron emission tomography (PET) several years before the onset of dementia. The aim of this study was to assess amyloid network topology in nondemented individuals with early stage Aβ accumulation, defined as abnormal CSF Aβ42 levels and normal Florbetapir PET (CSF+/PET−), and more advanced Aβ accumulation, defined as both abnormal CSF Aβ42 and Florbetapir PET (CSF+/PET+). The amyloid networks were built using correlations in the mean 18F-florbetapir PET values between 72 brain regions and analyzed using graph theory analyses. Our findings showed an association between early amyloid stages and increased covariance as well as shorter paths between several brain areas that overlapped with the default-mode network (DMN). Moreover, we found that individuals with more advanced amyloid accumulation showed more widespread changes in brain regions both within and outside the DMN. These findings suggest that amyloid network topology could potentially be used to assess disease progression in the predementia stages of AD.

Keywords

Male, graph theory, Prodromal Symptoms, Severity of Illness Index, cerebrospinal fluid, Diagnostic Self Evaluation, Alzheimer Disease, Neural Pathways, Humans, Cognitive Dysfunction, Aged, Aged, 80 and over, Brain Mapping, Memory Disorders, Amyloid beta-Peptides, Aniline Compounds, florbetapir PET, amyloid, Brain, Original Articles, Middle Aged, brain networks, Positron-Emission Tomography, Disease Progression, Ethylene Glycols, Female, Radiopharmaceuticals, Biomarkers

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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    18
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
18
Top 10%
Average
Top 10%
Green
Funded by
EC| BIOFINDER
Project
BIOFINDER
New biomarkers for Alzheimer’s & Parkinson’s diseases - key tools for early diagnosis and drug development
  • Funder: European Commission (EC)
  • Project Code: 311292
  • Funding stream: FP7 | SP2 | ERC
Validated by funder
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
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