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Europe PubMed Central
Article . 2019
Data sources: PubMed Central
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Steady‐state imaging with inhomogeneous magnetization transfer contrast using multiband radiofrequency pulses

Authors: Malik, Shaihan J.; Teixeira, Rui P. A. G.; West, Daniel J.; Wood, Tobias C.; Hajnal, Joseph V.;

Steady‐state imaging with inhomogeneous magnetization transfer contrast using multiband radiofrequency pulses

Abstract

PurposeInhomogeneous magnetization transfer (ihMT) is an emerging form of MRI contrast that may offer high specificity for myelinated tissue. Existing ihMT and pulsed MT sequences often use separate radiofrequency pulses for saturation and signal excitation. This study investigates the use of nonselective multiband radiofrequency pulses for simultaneous off‐resonance saturation and on‐resonance excitation specifically for generation of ihMT contrast within rapid steady‐state pulse sequences.Theory and MethodsA matrix‐based signal modeling approach was developed and applied for both balanced steady state free precession and spoiled gradient echo sequences, accounting specifically for multiband pulses. Phantom experiments were performed using a combination of balanced steady state free precession and spoiled gradient echo sequences, and compared with model fits. A human brain imaging exam was performed using balanced steady state free precession sequences to demonstrate the achieved contrast.ResultsA simple signal model derived assuming instantaneous radiofrequency pulses was shown to agree well with full integration of the governing equations and provided fits to phantom data for materials with strong ihMT contrast (PL161 root mean square error = 0.9%, and hair conditioner root mean square error = 2.4%). In vivo ihMT ratio images showed the expected white matter contrast that has been seen by other ihMT investigations, and the observed ihMT ratios corresponded well with predictions.ConclusionsihMT contrast can be generated by integrating multiband radiofrequency pulses directly into both spoiled gradient echo and balanced steady state free precession sequences, and the presented signal modeling approach can be used to understand the acquired signals.

Country
United Kingdom
Keywords

Male, Full Paper, Full Papers—Imaging Methodology, Phantoms, Imaging, Radio Waves, magnetization transfer, Reproducibility of Results, Neuroimaging, Models, Theoretical, ihMT, dipolar order, Magnetic Resonance Imaging, Sensitivity and Specificity, White Matter, Magnetics, Young Adult, Image Processing, Computer-Assisted, Humans, Computer Simulation, myelin imaging, inhomogeneous MT, Algorithms, Myelin Sheath

27 references, page 1 of 3

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
8
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Average
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Funded by
UKRI| EPSRC Centre for Doctoral Training in Medical Imaging
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: EP/L015226/1
  • Funding stream: EPSRC
,
WT| King's College London Medical Engineering Centre of Research Excellence
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 203148
  • Funding stream: Innovations
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